The impact of prolonged high-concentration cortisol exposure on cognitive function and risk factors: Evidence from Cushing's disease patients

Journal of Alzheimer s Disease Reports, Год журнала: 2025, Номер 9

Опубликована: Янв. 1, 2025

Background Prolonged high-concentration cortisol exposure may impair cognitive function, but its mechanisms and risk factors remain unclear in humans. Objective Using Cushing's disease patients as a model, this study explores these effects develops predictive model to aid managing high-risk patients. Methods This single-center retrospective included 107 (January 2020–January 2024) at the First Medical Center of PLA General Hospital. Cognitive assessed using Montreal Assessment, revealed 58 with impairment 49 normal function. Patients were divided into training (n = 53) validation cohorts 54) for constructing validating model. Risk identified via univariate analysis least absolute shrinkage selection operator regression, nomogram prediction was developed. Performance evaluated receiver operating characteristic (ROC) curves, calibration decision curve (DCA). Results Cortisol AM/PM ratio, 8 a.m. concentration, body mass index, fasting plasma glucose significant impairment. The demonstrated strong ability, ROC values 0.80 (training) 0.91 (validation). DCA indicated superior clinical utility compared treating all or no Conclusions confirms impact prolonged high on function identifies key factors. offers robust performance, providing valuable tool patients’ health informing strategies other cortisol-related disorders.

Язык: Английский

Physical symptoms and inflammatory levels characterize post-COVID-19 depressive episodes compared to non-post-COVID-19 depression

Journal of Affective Disorders, Год журнала: 2025, Номер 383, С. 410 - 416

Опубликована: Май 5, 2025

Язык: Английский