Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 10, 2025
Abstract
Cannabis
use
in
pregnancy
is
associated
with
low
birthweight
outcomes.
Recent
preclinical
data
suggests
that
maternal
Δ9-tetrahydrocannabinol
(THC)
exposure
leads
to
decreases
followed
by
early
cardiac
deficits
offspring.
Currently,
no
studies
have
explored
an
intervention
for
these
THC-induced
deficits.
Omega-3
fatty
acids
been
shown
exhibit
cardioprotective
effects.
In
this
present
study,
we
demonstrated
dietary
supplementation
of
omega-3
ameliorates
both
fetal
growth
and
postnatal
Our
indicates
may
be
underpinned
alterations
hepatic
reduction
markers
collagen
deposition.
Interestingly,
the
effects
omega-3s
further
underscored
decreased
signaling
endocannabinoid
system.
With
increasing
rates
cannabis
recent
evidence
subsequent
cardiometabolic
aberrations
offspring,
our
a
potential
disturbances
International Journal of Environmental Research and Public Health,
Год журнала:
2022,
Номер
19(17), С. 10846 - 10846
Опубликована: Авг. 31, 2022
Pregestational
type
1
(T1DM)
and
2
(T2DM)
diabetes
mellitus
gestational
(GDM)
are
associated
with
increased
rates
of
adverse
maternal
neonatal
outcomes.
Adverse
outcomes
more
common
in
women
pregestational
compared
to
GDM;
although,
conflicting
results
have
been
reported.
This
systematic
review
aims
summarise
synthesise
studies
that
pregnancy
pregnancies
complicated
by
GDM.
Three
databases,
Pubmed,
EBSCOhost
Scopus
were
searched
identify
T1DM
T2DM,
A
total
20
met
the
inclusion
criteria
included
this
review.
Thirteen
including
caesarean
section,
preterm
birth,
congenital
anomalies,
pre-eclampsia,
hypoglycaemia,
macrosomia,
intensive
care
unit
admission,
stillbirth,
Apgar
score,
large
for
age,
induction
labour,
respiratory
distress
syndrome
miscarriages
compared.
Findings
from
confirm
is
frequent
complications
than
Taken
together,
highlights
risks
posed
all
types
need
improve
educate
on
importance
maintaining
optimal
glycaemic
control
mitigate
these
risks.
Scientific Reports,
Год журнала:
2020,
Номер
10(1)
Опубликована: Янв. 17, 2020
1
in
5
women
report
cannabis
use
during
pregnancy,
with
nausea
cited
as
their
primary
motivation.
Studies
show
that
(-)-△9-tetrahydrocannabinol
(Δ9-THC),
the
major
psychoactive
ingredient
cannabis,
causes
fetal
growth
restriction,
though
mechanisms
are
not
well
understood.
Given
critical
role
of
placenta
to
transfer
oxygen
and
nutrients
from
mother,
fetus,
any
compromise
development
fetal-placental
circulation
significantly
affects
maternal-fetal
exchange
thereby,
growth.
The
goal
this
study
was
examine,
rats,
impact
maternal
Δ9-THC
exposure
on
development,
neonatal
outcomes,
placental
development.
Dams
received
a
daily
intraperitoneal
injection
(i.p.)
vehicle
control
or
(3
mg/kg)
embryonic
(E)6.5
through
22.
were
allowed
deliver
normally
measure
pregnancy
subset
sacrificed
at
E19.5
for
assessment
via
immunohistochemistry
qPCR.
Gestational
resulted
pups
born
symmetrical
catch
up
by
post-natal
day
(PND)21.
During
there
no
changes
food
intake,
weight
gain,
litter
size,
gestational
length.
placentas
Δ9-THC-exposed
pregnancies
exhibited
phenotype
characterized
increased
labyrinth
area,
reduced
Epcam
expression
(marker
trophoblast
progenitors),
altered
blood
space,
decreased
capillary
area
an
recruitment
pericytes
greater
collagen
deposition,
when
compared
controls.
Further,
had
glucose
transporter
(GLUT1)
glucocorticoid
receptor
(GR)
response
exposure.
In
conclusion,
effectively
compromised
growth,
which
may
be
result
adversely
affected
zone
These
findings
implicate
GLUT1
target
provide
potential
mechanism
restriction
observed
who
pregnancy.
Can J Public Health,
Год журнала:
2018,
Номер
110(1), С. 76 - 84
Опубликована: Ноя. 1, 2018
Forthcoming
legislative
changes
will
legalize
and
make
cannabis
widely
available
in
Canada.
We
conducted
an
analysis
of
Ontario's
birth
registry
to
determine
recent
trends
correlates
use
pregnancy.
a
population-based
retrospective
cohort
study
assembled
from
the
Better
Outcomes
Registry
&
Network
(BORN)
Ontario
database,
covering
live
births
stillbirths
between
April
2012
December
2017.
Trends
self-reported
pregnancy
were
analyzed
according
maternal
age
area-level
socio-economic
status
(SES)
using
log
binomial
regression
analysis.
A
total
10,731
women
reported
Prevalence
increased
1.2%
1.8%
2017
(p-trend,
<
0.001),
equivalent
relative
increase
61%
(relative
risk
[RR]
1.61,
95%
confidence
interval
[CI]
1.51
1.72).
The
crude
prevalence
among
aged
15
24
years
lowest
two
income
quintiles
was
6.7%,
compared
0.3%
35
over
highest
three
(RR
24.59,
CI
21.98
27.52).
majority
(52.0%)
users
15–24
54.7%
quintiles.
Cannabis
has
since
about
2%
pregnancies
Increases
predominately
younger
ages
those
lower
SES,
these
groups
account
for
half
users.
Promoting
cessation
could
lead
improved
perinatal
later
childhood
outcomes
reduce
health
inequalities.
American Journal of Physical Anthropology,
Год журнала:
2019,
Номер
169(1), С. 3 - 11
Опубликована: Фев. 16, 2019
Abstract
Objectives
Socioeconomic
status
(SES)
is
a
powerful
determinant
of
health,
but
the
underlying
biological
mechanisms
are
poorly
understood.
This
study
investigates
whether
levels
DNA
methylation
at
CpG
sites
across
genome
associated
with
SES
in
cohort
young
adults
Philippines.
Methods
was
assayed
Illumina
HumanMethylation450
Bead
Chip,
leukocytes
from
489
participants
Cebu
Longitudinal
Health
and
Nutrition
Survey
(mean
age
=
20.9
years).
measured
infancy/childhood
adulthood,
based
on
composite
measures
income,
assets,
education.
Genome‐wide
analysis
variable
probes
identified
significantly
after
adjustment
for
multiple
comparisons.
Functional
enrichment
used
to
identify
pathways
these
sites.
Results
A
total
2,546
sites,
1,537
annotated
genes,
were
differentially
methylated
association
SES.
In
comparison
high
SES,
low
increased
1,777
decreased
769
over‐representation
related
immune
function,
skeletal
development,
development
nervous
system.
Conclusions
predicts
large
number
genome.
The
scope
associations
commensurate
wide
range
systems
health
outcomes
that
shaped
by
findings
suggest
may
play
an
important
role.
BMC Pregnancy and Childbirth,
Год журнала:
2018,
Номер
18(1)
Опубликована: Сен. 10, 2018
Gestational
diabetes
mellitus
(GDM)
is
the
most
frequent
complication
during
pregnancy.
Untreated
GDM
a
severe
threat
to
maternal
and
neonatal
health.
Based
on
recent
evidence,
up
15%
of
all
pregnancies
may
be
affected
by
GDM.
We
hypothesized
that
in
rural
birth
cohort,
higher
BMI
adverse
socioeconomic
conditions
would
promote
GDM,
which
turn
lead
effects
pregnancy
outcomes.
A
source
of
support
during
birth
could
be
the
solution
to
negative
outcomes
for
mother
and
her
baby.
To
improve
birthing
experience
increase
positive
outcomes,
sources
pregnancy
should
evaluated
understood.
The
goal
this
review
was
synthesize
existing
literature
on
how
doulas
might
outcomes.
This
scoping
also
aimed
shed
light
impact
emotional
childbirth
can
have
health
well-being
child.
PubMed
EBSCOhost
were
used
identify
articles
using
search
words
with
Boolean
operators
"doulas"
AND
"labor
support"
"birth
outcomes"
"pregnancy"
"effects
labor."
eligibility
criteria
article
selection
included
primary
studies
investigating
contributed
in
indicated
that
doula
guidance
perinatal
care
associated
delivery
including
reduced
cesarean
sections,
premature
deliveries,
length
labor.
Moreover,
provided
by
seen
reduce
anxiety
stress.
Doula
support,
specifically
low-income
women,
shown
breastfeeding
success,
quicker
lactogenesis
continued
weeks
after
childbirth.
Doulas
a
great
resource
mothers,
consideration
given
them
more,
as
they
may
study
raised
questions
about
accessibility
help
mitigate
disparities
among
women
from
different
socioeconomic
levels.
BJOG An International Journal of Obstetrics & Gynaecology,
Год журнала:
2019,
Номер
127(1), С. 8 - 16
Опубликована: Сен. 17, 2019
Background
With
expanding
recreational
cannabis
legalisation,
pregnant
women
and
their
offspring
are
at
risk
of
potentially
harmful
consequences.
Objectives
To
assess
the
prevalence
use
among
women,
health
outcomes
associated
with
prenatal
use,
potential
impact
legalisation
on
this
population.
Search
strategy
Five
databases
grey
literature
were
systematically
searched
(2000–2019).
Selection
criteria
Human
studies
published
in
English
or
French
reporting
high‐income
countries.
Data
collection
analysis
study
characteristics,
substance
extracted
qualitatively
synthesised.
Main
results
Forty‐one
publications
met
our
inclusion
criteria.
The
overall
varied
substantially
(min–max:
0.24–22.6%),
greatest
first
trimester.
In
three
temporal
data
available,
rates
increased
across
years.
Only
7/41
5/41
provided
information
gestational
age
exposure
frequency
respectively.
concomitant
alcohol,
illicit
drugs,
tobacco
was
higher
users
than
nonusers.
Prenatal
select
neonatal,
but
not
maternal,
outcomes.
There
insufficient
to
compare
between
pre‐
post‐legalisation
periods.
Conclusion
Cannabis
is
prevalent
may
be
adverse
neonatal
Future
should
exposure,
usage
patterns
prior
following
legalisation.
Tweetable
abstract
Women
who
consume
during
pregnancy
could
predisposing
newborns
poor
birth
