The mediation role of gray matter volume in the relationship between childhood maltreatment and psychological resilience in adolescents with first-episode major depressive disorder DOI Creative Commons
Hui Chen,

Peiqu Liu,

Xianliang Chen

и другие.

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 24, 2024

Previous studies have revealed morphologic alterations in patients with major depressive disorder (MDD) experiences of childhood trauma. However, the underlying neural mechanisms remain largely unknown. This study aims to explore brain structural changes and their possible mediation role relationship between maltreatment psychological resilience drug-naïve adolescents first-episode MDD. A total 57 MDD 36 healthy controls (HCs) completed T1-weighted magnetic resonance imaging scan. The adverse current were assessed using Childhood Trauma Questionnaire-Short Form Connor Davidson Resilience Scale, respectively. voxel-based morphometry approach was applied examine gray matter volume (GMV). Compared HCs, had significantly reduced GMV volumes left fusiform gyrus, right orbitofrontal superior temporal calcarine cortex, middle frontal angular precuneus, posterior cingulate central as well increased lenticular putamen pallidum. cortex found be negatively correlated severity emotional abuse positively level resilience. Moreover, might partially mediate present provided further evidence for impairments Our findings also confirmed important depression-related growth characteristics during adolescent maturation.

Язык: Английский

Glucocorticoid Receptor Gene (NR3C1) Methylation Childhood Maltreatment Multilevel Reward Responsiveness and Depressive and Anxiety Symptoms: A Neuroimaging Epigenetic Study DOI Creative Commons

Yajing Xu,

Shan Yang, Cong Cao

и другие.

NeuroImage, Год журнала: 2025, Номер 306, С. 121003 - 121003

Опубликована: Янв. 7, 2025

Although epigenomic and environment interactions (Epigenome × Environment; Epi E) might constitute a novel mechanism underlying reward processing direct evidence is still scarce. We conducted the first longitudinal study to investigate extent which DNA methylation of stress-related gene-NR3C1-interacts with childhood maltreatment in association young adult responsiveness (RR) downstream risk depressive (anhedonia dimension particular) anxiety symptoms. A total 192 Chinese university students aged 18∼25 (M NR3C1-1F significantly interacted on RewP but not delta theta components or self-reported RR. The severity exposure number were negatively associated among individuals heightened positively blunted demonstrating "goodness-of-fit" interaction. This interaction was specifically linked anhedonia scores current findings provide preliminary for an E highlight cross-level analyses electrophysiological signals advance knowledge biological foundation stress-induced function relevant However caution should be paid generalizability these high-risk clinical samples given high-functioning characteristic present sample.

Язык: Английский

Процитировано

0
The mediation role of gray matter volume in the relationship between childhood maltreatment and psychological resilience in adolescents with first-episode major depressive disorder DOI Creative Commons
Hui Chen,

Peiqu Liu,

Xianliang Chen

и другие.

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 24, 2024

Previous studies have revealed morphologic alterations in patients with major depressive disorder (MDD) experiences of childhood trauma. However, the underlying neural mechanisms remain largely unknown. This study aims to explore brain structural changes and their possible mediation role relationship between maltreatment psychological resilience drug-naïve adolescents first-episode MDD. A total 57 MDD 36 healthy controls (HCs) completed T1-weighted magnetic resonance imaging scan. The adverse current were assessed using Childhood Trauma Questionnaire-Short Form Connor Davidson Resilience Scale, respectively. voxel-based morphometry approach was applied examine gray matter volume (GMV). Compared HCs, had significantly reduced GMV volumes left fusiform gyrus, right orbitofrontal superior temporal calcarine cortex, middle frontal angular precuneus, posterior cingulate central as well increased lenticular putamen pallidum. cortex found be negatively correlated severity emotional abuse positively level resilience. Moreover, might partially mediate present provided further evidence for impairments Our findings also confirmed important depression-related growth characteristics during adolescent maturation.

Язык: Английский

Процитировано

1