Cell-mediated delivery of synthetic nano- and microparticles

Journal of Controlled Release, Год журнала: 2017, Номер 259, С. 92 - 104

Опубликована: Фев. 8, 2017

Язык: Английский

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Chemically Engineered Immune Cell‐Derived Microrobots and Biomimetic Nanoparticles: Emerging Biodiagnostic and Therapeutic Tools

Advanced Science, Год журнала: 2021, Номер 8(8)

Опубликована: Март 1, 2021

Abstract Over the past decades, considerable attention has been dedicated to exploitation of diverse immune cells as therapeutic and/or diagnostic cell‐based microrobots for hard‐to‐treat disorders. To date, a plethora therapeutics based on alive cells, surface‐engineered immunocytes’ cell membranes, leukocyte‐derived extracellular vesicles or exosomes, and artificial have investigated few introduced into market. These systems take advantage unique characteristics functions including their presence in circulating blood various tissues, complex crosstalk properties, high affinity different self foreign markers, potential on‐demand navigation activity, production variety chemokines/cytokines, well being cytotoxic particular conditions. Here, latest progress development engineered diagnostics inspired by ameliorate cancer, inflammatory conditions, autoimmune diseases, neurodegenerative disorders, cardiovascular complications, infectious diseases is reviewed, finally, perspective clinical application delineated.

Язык: Английский

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Biomimetic Aggregation‐Induced Emission Nanodots with Hitchhiking Function for T Cell‐Mediated Cancer Targeting and NIR‐II Fluorescence‐Guided Mild‐Temperature Photothermal Therapy

Advanced Functional Materials, Год журнала: 2022, Номер 32(45)

Опубликована: Авг. 3, 2022

Abstract Photothermal therapy (PTT) holds potential as an alternative approach for effective cancer treatment since it exerts minimal side effects on normal tissues. However, the photothermal stimulation increases expression of heat shock protein (HSP) in tumor cells, rendering cells insensitive to and thus constraining PTT. In this study, biomimetic aggregation‐induced emission (AIE) agents with hitchhiking ability (DC@BPBBT dots) are developed by coating nanoaggregates NIR AIE polymeric dendritic cell (DC) membranes. Notably, inner nanoaggregate (BPBBT bright second‐window near infrared (NIR‐II) fluorescence (quantum yield up 3.47%) a high conversion performance (photothermal efficiency 30.5%), outer membrane can facilitate DC@BPBBT dots endogenous T enhance delivery about 1.2 times. Furthermore, activate stimulate vivo secrete cytokine necrosis factor α (TNF‐α), which reduce 70 (HSP70) render more sensitive heat. This study not only provides inhibition strategy based immune interactions but also hitchhike drug immunotherapy.

Язык: Английский

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Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 509 - 525

Опубликована: Янв. 1, 2023

Abstract: Nanoparticle-based drug delivery systems have been designed to treat various diseases. However, many problems remain, such as inadequate tumor targeting and poor therapeutic outcomes. To overcome these obstacles, cell-based developed. Candidates for cell-mediated include blood cells, immune stem cells with innate tropism low immunogenicity; they act a disguise deliver the payload. In systems, agents are encapsulated intracellularly or attached surface of plasma membrane transported desired site. Here, we review pros cons therapies discuss their homing mechanisms in microenvironment. addition, different strategies load inside on circulating current applications wide range disease treatments summarized. Keywords: delivery, ability, microenvironment, loading

Язык: Английский

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In situ cellular hitchhiking of nanoparticles for drug delivery

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 204, С. 115143 - 115143

Опубликована: Ноя. 24, 2023

Язык: Английский

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