Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(37)
Опубликована: Май 23, 2023
Fluorescence
imaging
utilizing
traditional
organic
fluorophores
is
extensively
applied
in
both
cellular
and
vivo
studies.
However,
it
faces
significant
obstacles,
such
as
low
signal-to-background
ratio
(SBR)
spurious
positive/negative
signals,
primarily
due
to
the
facile
diffusion
of
these
fluorophores.
To
cope
with
this
challenge,
orderly
self-assembled
functionalized
have
gained
attention
past
decades.
These
can
create
nanoaggregates
via
a
well-ordered
self-assembly
process,
thus
prolonging
their
residency
time
within
cells
settings.
The
development
self-assembled-based
an
emerging
field,
such,
review,
we
present
summary
progress
challenges
fluorophores,
focusing
on
history,
mechanisms,
biomedical
applications.
We
hope
that
insights
provided
herein
will
assist
scientists
further
developing
for
situ
imaging,
sensing,
therapy.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(24)
Опубликована: Март 28, 2022
Cyanines
have
been
widely
used
as
the
photosensitizers
(PSs)
in
biomedical
field,
but
controlling
their
molecular
aggregates
nanoparticles
(NPs)
remains
a
major
challenge.
Moreover,
impact
of
aggregate
behaviors
cyanines
on
photosensitization
is
still
unclear.
Herein,
first
anionic
cyanine
PSs
based
tricyanofuran
end
group
designed
by
achieving
supramolecular
J-type
NPs
via
counterion
engineering.
Our
results
indicate
that
can
not
only
bring
significantly
red-shifted
emission,
negatively
charged
surface,
and
high
photostability,
also
enable
significant
5-fold
increase
singlet
oxygen
generation
efficiency
compared
to
nonaggregate
state,
providing
strong
experimental
evidence
for
superiority
J-aggregates
enhancing
photosensitization.
Thus,
combined
with
mitochondria-targeting
ability,
show
remarkable
vivo
antitumor
phototheranostic
efficacy,
making
them
potential
clinical
use.
Journal of Materials Chemistry C,
Год журнала:
2023,
Номер
11(9), С. 3143 - 3161
Опубликована: Янв. 1, 2023
This
review
discusses
organic
room
temperature
phosphorescent
materials
for
the
emitting
layer
of
OLEDs.
The
existing
circumstances,
potential
and
challenges
metal-free
OLEDs
are
summarized.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(27), С. 12290 - 12298
Опубликована: Июнь 28, 2022
This
work
showcases
chiral
complementarity
in
aromatic
stacking
interactions
as
an
effective
tool
to
optimize
the
chiroptical
and
electrochemical
properties
of
perylene
diimides
(PDIs).
PDIs
are
a
notable
class
robust
dye
molecules
their
rich
photo-
electrochemistry
potential
chirality
make
them
ideal
organic
building
blocks
for
optoelectronic
materials.
By
exploiting
new
bay
connectivity
twisted
PDIs,
dynamic
bis-PDI
macrocycle
(the
"Pink
Box")
is
realized
which
homochiral
PDI–PDI
π–π
switched
on
exclusively.
Using
range
experimental
computational
techniques,
we
uncover
three
important
implications
macrocycle's
PDI
optoelectronics.
First,
intramolecular
anchor
units,
yielding
enantiomers
with
half-lives
extended
over
400-fold,
from
minutes
days
(in
solution)
or
years
solid
state).
Second,
H-type
aggregation
affords
red-shifted
circularly
polarized
luminescence
one
highest
dissymmetry
factors
any
small
molecule
solution
(glum
=
10–2
at
675
nm).
Finally,
excellent
through-space
π-orbital
overlap
stabilizes
reduced
states,
akin
covalent
functionalization
electron-withdrawing
groups.
ACS Materials Letters,
Год журнала:
2023,
Номер
5(6), С. 1752 - 1759
Опубликована: Май 19, 2023
Development
of
near-infrared
(NIR)
Type-I
photosensitizers
is
attracting
tremendous
attention
to
overcome
the
limitation
traditional
O2-dependent
Type-II
photosensitizers,
but
huge
challenges
remain.
Herein,
a
promising
concept
was
put
forward
by
lowering
energy
lowest
triplet
excited
state
(T1)
photosensitizer
below
threshold
for
oxygen
sensitization
via
maximizing
electronic
exchange
energy.
By
taking
advantage
low
intramolecular
charge
transfer
(ICT)
state,
pyrrolidine
as
an
electron
donor
conjugated
at
bay
position
perylenediimide
(PDI)
produce
PDIPy
that
acts
novel
with
NIR
absorbance
and
T1
level.
With
application
PDIPy,
PDT
realized
effective
generation
O2•
–.
Supramolecular
nanoparticles
(NanoPDIPy)
assembling
from
showed
excellent
in
vitro
vivo
phototherapeutic
efficacy
against
cancer
either
normoxia
or
hypoxia
upon
730
nm
laser
irradiation.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(37)
Опубликована: Май 23, 2023
Fluorescence
imaging
utilizing
traditional
organic
fluorophores
is
extensively
applied
in
both
cellular
and
vivo
studies.
However,
it
faces
significant
obstacles,
such
as
low
signal-to-background
ratio
(SBR)
spurious
positive/negative
signals,
primarily
due
to
the
facile
diffusion
of
these
fluorophores.
To
cope
with
this
challenge,
orderly
self-assembled
functionalized
have
gained
attention
past
decades.
These
can
create
nanoaggregates
via
a
well-ordered
self-assembly
process,
thus
prolonging
their
residency
time
within
cells
settings.
The
development
self-assembled-based
an
emerging
field,
such,
review,
we
present
summary
progress
challenges
fluorophores,
focusing
on
history,
mechanisms,
biomedical
applications.
We
hope
that
insights
provided
herein
will
assist
scientists
further
developing
for
situ
imaging,
sensing,
therapy.
