Application of MOF materials as drug delivery systems for cancer therapy and dermal treatment

Coordination Chemistry Reviews, Год журнала: 2021, Номер 451, С. 214262 - 214262

Опубликована: Окт. 27, 2021

Язык: Английский

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Bioinspired Framework Catalysts: From Enzyme Immobilization to Biomimetic Catalysis

Chemical Reviews, Год журнала: 2023, Номер 123(9), С. 5347 - 5420

Опубликована: Апрель 12, 2023

Enzymatic catalysis has fueled considerable interest from chemists due to its high efficiency and selectivity. However, the structural complexity vulnerability hamper application potentials of enzymes. Driven by practical demand for chemical conversion, there is a long-sought quest bioinspired catalysts reproducing even surpassing functions natural As nanoporous materials with surface areas crystallinity, metal-organic frameworks (MOFs) represent an exquisite case how enzymes their active sites are integrated into porous solids, affording heterogeneous superior stability customizable structures. In this review, we comprehensively summarize advances MOFs catalysis, discuss design principle various MOF-based catalysts, such as MOF-enzyme composites embedded sites, explore utility these in different reactions. The advantages enzyme mimetics also highlighted, including confinement, templating effects, functionality, comparison homogeneous supramolecular catalysts. A perspective provided potential solutions addressing current challenges MOF catalysis.

Язык: Английский

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Multicharged cyclodextrin supramolecular assemblies

Chemical Society Reviews, Год журнала: 2022, Номер 51(11), С. 4786 - 4827

Опубликована: Янв. 1, 2022

Multicharged cyclodextrin (CD) supramolecular assemblies, including those based on positively/negatively charged modified mono-6-deoxy-CDs, per-6-deoxy-CDs, and random 2,3,6-deoxy-CDs, as well parent CDs binding guests, have been extensively applied in chemistry, materials science, medicine, biological catalysis, other fields. In this review, we primarily focus summarizing the recent advances encapsulating especially construction process of assemblies their applications. Compared with uncharged CDs, multicharged display remarkably high antiviral antibacterial activity efficient protein fibrosis inhibition. Meanwhile, can interact oppositely dyes, drugs, polymers, biomacromolecules to achieve effective encapsulation aggregation. Consequently, CD show great advantages improving drug-delivery efficiency, luminescence properties materials, molecular recognition imaging, toughness hydrogels, addition enabling multistimuli-responsive assemblies. These features are anticipated not only promote development CD-based chemistry but also contribute rapid exploitation these diverse interdisciplinary

Язык: Английский

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Macrocycle-derived hierarchical porous organic polymers: synthesis and applications

Chemical Society Reviews, Год журнала: 2021, Номер 50(20), С. 11684 - 11714

Опубликована: Янв. 1, 2021

This review article specifically highlights the synthetic strategies and promising applications of macrocycle-derived hierarchical porous organic polymers (POPs).

Язык: Английский

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Cyclodextrin metal–organic frameworks and derivatives: recent developments and applications

Chemical Society Reviews, Год журнала: 2022, Номер 51(12), С. 5175 - 5213

Опубликована: Янв. 1, 2022

In this review, we provide an elaborate overview of the state-of-the-art synthesis, design, properties and applications cyclodextrin metal-organic frameworks (CD-MOFs), CD-MOF hybrids materials derived from CD-MOFs.

Язык: Английский

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Macrocyclic Supramolecular Assemblies Based on Hyaluronic Acid and Their Biological Applications

Accounts of Chemical Research, Год журнала: 2022, Номер 55(23), С. 3417 - 3429

Опубликована: Ноя. 16, 2022

ConspectusHyaluronic acid (HA), which contains multiple carboxyl, hydroxyl, and acetylamino groups is an agent that targets tumors, has drawn great attention in supramolecular diagnosis treatment research. It can not only assemble directly with macrocyclic host–guest complexes through hydrogen bonding electrostatic interactions but also be modified compounds or functional guest molecules by amidation reaction used for further assembly. Macrocycles play a main role the construction of drug carriers, targeted imaging agents, hydrogels, such as cyclodextrins cucurbit[n]urils, encapsulate photosensitizers, drugs, other via interactions. Therefore, formed assemblies respond to various stimuli, enzymes, light, electricity, magnetism controlled delivery, enhance luminescence intensity assembly, improve loading capacity. In addition, nanosupramolecular assembly HA biocompatibility reduce toxicity side effects, cell permeability; thus, extensive application value biomedical This Account mainly focuses on based HA, especially their biological applications progress field, these include (i) guest-modified pyridinium-, adamantane-, peptide-, functional-group-modified along cyclodextrin cucurbit[n]uril assemblies; (ii) macrocycle-modified derivatives guests; (iii) direct between unmodified cyclodextrin- cucurbit[n]uril-based complexes. Particularly, we discussed important HA-based roles included improving water solubility efficacy hydrophobic enhancing luminescent assemblies, inducing room temperature phosphorescence providing energy transfer systems, constructing multi-stimulus-responsive situ formation hydrogels. Additionally, believe obtaining in-depth knowledge encompasses many challenges regarding wound healing, soft materials would certainly contribute rapid development treatment.

Язык: Английский

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Helically Chiral Hybrid Cyclodextrin Metal–Organic Framework Exhibiting Circularly Polarized Luminescence

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(21), С. 9380 - 9389

Опубликована: Май 20, 2022

Three achiral polycyclic aromatic fluorophores─namely, 1-pyrenecarboxylic acid, 9-anthracenecarboxylic and perylene-3,9-dicarboxylic acid─were chosen based on their desired properties before being incorporated into the construction of a K+-carrying gamma-cyclodextrin (γ-CD)-based metal–organic framework (CD-MOF-1) γ-CD-containing hybrid frameworks (CD-HFs). Among these fluorophores, only pyrene-carrying one shows significant noncovalent bonding interactions with γ-CD in solution. This fluorophore is encapsulated CD-HF trigonal superstructure instead common cubic CD-MOF-1 found case other two fluorophores. Single-crystal X-ray diffraction analysis reveals π-stacked chiral positioning inside (γ-CD)2 tunnels held uniformly around an enantiomorphous 32 screw axis along c direction solid-state structure. helix-like structure demonstrates additional level chirality over above point-chiral stereogenic centers axial associated self-assembled These arrangements result specifically generated photophysical chiroptical properties, such as controlled emergence circularly polarized luminescence (CPL) emission. In this manner, complete understanding mechanism transfer from host (CD-HF) to has been achieved, attribute which often missing development materials CPL.

Язык: Английский

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Ultrafast Synthesis of Graphene‐Embedded Cyclodextrin‐Metal‐Organic Framework for Supramolecular Selective Absorbency and Supercapacitor Performance

Advanced Science, Год журнала: 2023, Номер 10(31)

Опубликована: Авг. 27, 2023

Limited by preparation time and ligand solubility, synthetic protocols for cyclodextrin-based metal-organic framework (CD-MOF), as well subsequent derived materials with improved stability properties, still remains a challenge. Herein, an ultrafast, environmentally friendly, cost-effective microwave method is proposed, which induced graphene oxide (GO) to design CD-MOF/GOs. This applicable technique can control the crystal size of CD-MOFs from macro- nanocrystals. CD-MOF/GOs are investigated new type supramolecular adsorbent. It selectively adsorb dye molecule methylene green (MG) owing synergistic effect between hydrophobic nanocavity CDs, abundant O-containing functional groups GO in composites. Following high temperature calcination, resulting N, S co-doped porous carbons exhibit capacitance 501 F g-1 at 0.5 A , stable cycling 90.1% capacity retention after 5000 cycles. The carbon exhibits good electrochemical performance due its surface containing numerous electrochemically active sites adsorption carbonization. strategy incorporating variety molecules into optimizes properties their materials, furthering development toward fabrication zeitgeisty high-performance energy storage devices.

Язык: Английский

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Active cellulose acetate/purple sweet potato anthocyanins@cyclodextrin metal-organic framework/eugenol colorimetric film for pork preservation

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 263, С. 130523 - 130523

Опубликована: Фев. 28, 2024

Язык: Английский

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Cyclodextrin-Modified Nanomaterials for Drug Delivery: Classification and Advances in Controlled Release and Bioavailability

Pharmaceutics, Год журнала: 2021, Номер 13(12), С. 2131 - 2131

Опубликована: Дек. 10, 2021

In drug delivery, one widely used way of overcoming the biopharmaceutical problems present in several active pharmaceutical ingredients, such as poor aqueous solubility, early instability, and low bioavailability, is formation inclusion compounds with cyclodextrins (CD). recent years, use CD derivatives combination nanomaterials has shown to be a promising strategy for formulating new, optimized systems. The goals this review are give in-depth knowledge critical appraisal main CD-modified or CD-based lipid-based nanocarriers, natural synthetic polymeric nanosponges, graphene derivatives, mesoporous silica nanoparticles, plasmonic magnetic quantum dots other miscellaneous systems nanovalves, metal-organic frameworks, Janus nanofibers. Special attention given nanosystems that achieve controlled release increase their bioavailability during vivo studies.

Язык: Английский

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