Organic Letters, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
An efficient electrochemical bromocyclization of allenols has been realized for the synthesis spirocyclic 2,5-dihydrofurans. The reaction used commercially available and nontoxic KBr as brominating source in a simple setup under open-air conditions. Notably, optically active products can be obtained from 2,3-allenols without any racemization, further enhancing synthetic utility.
Язык: Английский
Journal of the American Chemical Society, Год журнала: 2022, Номер 144(36), С. 16252 - 16261
Опубликована: Авг. 31, 2022
Chiral iridium complexes derived from Crabtree's catalyst are highly useful in modern hydrogenations of olefins attributed to high reactivity, stereoselectivity, and stability. Despite that these precatalysts pH neutral, the reaction mixtures turn acidic under hydrogenation conditions. This Perspective is devoted implications intrinsic Brønsted acidity catalytic intermediates asymmetric olefins. has often been used only as a rationale for side-product formation, more recent methodologies have started use this property advantageously. We hope serves stimulant development such compelling new hydrogenations. The inherent scientific opportunities utilizing or annihilating generated acid enormous, potential innovations outlined toward end.
Язык: Английский
Процитировано
18
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(28)
Опубликована: Май 11, 2023
Catalytic asymmetric hydrogenation of enamido phosphorus derivatives is one the most efficient methods for construction chiral amino products, among which congested tetra-substituted substrates remains an unaddressed challenge. In this study, we utilize a commercially available Rh-Josiphos system and stereoselective wide set cyclic β-enamido phosphonates/phosphine oxides, thus enabling access to β-amino compounds featuring two vicinal stereocenters. This protocol was broadly applicable different ring systems possessing various phosphonate/phosphine oxide groups further applied in preparation amino-phosphine ligands. DFT mechanistic explorations indicate that C=C migratory insertion into RhIII -H bond could be rate- stereo-determining step. The origins stereoselectivity are revealed through distortion/interaction analysis, primarily regulated by distinguished dispersion interactions steric repulsions.
Язык: Английский
Процитировано
10
Chinese Journal of Organic Chemistry, Год журнала: 2025, Номер 45(2), С. 717 - 717
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Patai's chemistry of functional groups, Год журнала: 2025, Номер unknown, С. 1 - 26
Опубликована: Фев. 26, 2025
Abstract The development of highly efficient catalysts for alkene hydrogenation has continuously received great attention, both from academia and industry. Cobalt‐based homogeneous have emerged as attractive alternatives to “traditional” precious‐metal in hydrogenation, owing the unique properties outstanding catalytic performance addition benefits low cost environmentally benign nature. In this chapter, advances cobalt‐catalyzed are summarized provide a comprehensive overview cobalt catalysts, their behavior, reaction mechanisms.
Язык: Английский
Процитировано
0
Organic Letters, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
An efficient electrochemical bromocyclization of allenols has been realized for the synthesis spirocyclic 2,5-dihydrofurans. The reaction used commercially available and nontoxic KBr as brominating source in a simple setup under open-air conditions. Notably, optically active products can be obtained from 2,3-allenols without any racemization, further enhancing synthetic utility.
Язык: Английский
Процитировано
0