Progress in Lewis-Acid-Templated Diels–Alder Reactions

Molecules, Год журнала: 2024, Номер 29(5), С. 1187 - 1187

Опубликована: Март 6, 2024

The synthesis of natural products with complicated architectures often requires the use segments functional groups that can be structurally transformed desired stereogenic centers. Bicyclic 𝛾-lactones have great potential as a suitable segment for product synthesis. However, stereoselective construction such functionalized bicyclic is not straightforward one might expect. template-mediated Diels-Alder reaction most powerful and versatile methods providing high regioselectivity stereoselectivity. In this reaction, diene linked to dienophile by temporary tether, allowing proceed efficiently, yielding used This review describes some important instances its application biologically active compounds.

Язык: Английский

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In Situ CALB Immobilization in Xerogel and Sonogel Employing TMOS as Silica Precursor and Polyethylene Glycol as Additive

Processes, Год журнала: 2024, Номер 12(11), С. 2411 - 2411

Опубликована: Ноя. 1, 2024

The immobilization of enzymes, especially lipases, presents a significant challenge in contemporary biotechnology due to their wide-ranging application industrial processes. Given the array available techniques for enzyme immobilization, this study aimed immobilize Candida antarctica B (CALB) lipase within silica xerogel and sonogel matrices obtained through sol–gel technique. Polyethylene glycol (PEG) was incorporated as an additive, with tetramethylorthosilicate (TMOS) serving precursor. This assessed operational stability, storage thermal properties resulting supports. Results revealed that both supports, supplemented PEG, maintained stability above 50% throughout 365-day period. Moreover, tests demonstrated support could be reused up 21 times, while exhibited 10 reuses. Thermal analysis further highlighted reduction deactivation constant elongation half-life time These observations suggest supports effectively shield from inactivation. Overall, these findings underscore potential utility PEG-enhanced various applications, providing valuable insights into operational, storage, stability.

Язык: Английский

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Advanced Technologies for Large Scale Supply of Marine Drugs

Marine Drugs, Год журнала: 2025, Номер 23(2), С. 69 - 69

Опубликована: Фев. 7, 2025

Marine organisms represent a source of unique chemical entities with valuable biomedical potentialities, broad diversity, and complexity. It is essential to ensure reliable sustainable supply marine natural products (MNPs) for their translation into commercial drugs other products. From structural point view few exceptions, MNPs pharmaceutical importance derive from the so-called secondary metabolism organisms. When production strategies rely on macroorganisms, harvesting or culturing coupled extraction procedures frequently remain only alternative producing these compounds an industrial scale. Their can often be implemented laboratory scale cultures bacterial, fungal, microalgal sources. However, diverse approach, combining traditional methods modern synthetic biology biosynthesis strategies, must considered invertebrate MNPs, as they are usually naturally accumulated in very small quantities. This review offers comprehensive examination various addressing challenges related supply, synthesis, scalability. also underscores recent biotechnological advancements that likely transform current industrial-scale manufacturing pharmaceuticals derived

Язык: Английский

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Modular Chemoenzymatic Cascade for Highly Diastereo- and Enantioselective Synthesis of 1,3-Disubstituted Tetrahydroisoquinolines

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 5426 - 5434

Опубликована: Март 18, 2025

Язык: Английский

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Brief analysis of Nav1.7 inhibitors: Mechanism of action and new research trends

Bioorganic & Medicinal Chemistry, Год журнала: 2025, Номер 128, С. 118180 - 118180

Опубликована: Апрель 6, 2025

Язык: Английский

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