Single-Atom Fe-Catalyzed Acceptorless Dehydrogenative Coupling to Quinolines

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(33), С. 23338 - 23347

Опубликована: Авг. 6, 2024

A single-atom iron catalyst was found to exhibit exceptional reactivity in acceptorless dehydrogenative coupling for quinoline synthesis, outperforming known homogeneous and nanocatalyst systems. Detailed characterizations, including aberration-corrected HAADF-STEM, XANES, EXAFS, jointly confirmed the presence of atomically dispersed centers. Various functionalized quinolines were efficiently synthesized from different amino alcohols a range ketones or alcohols. The achieved turnover number (TON) up 10

Язык: Английский

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Access of arylmethanes via iridium-catalyzed deoxygenative cross-coupling of aryl ketones with anilines/phenols

Journal of Catalysis, Год журнала: 2024, Номер 433, С. 115492 - 115492

Опубликована: Апрель 11, 2024

Язык: Английский

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Recent strategies and developments in the hydroboration of N-Heteroarenes mediated by transition and rare-earth metal complexes

Inorganica Chimica Acta, Год журнала: 2025, Номер unknown, С. 122594 - 122594

Опубликована: Фев. 1, 2025

Язык: Английский

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Computational and Experimental Studies on the α-Functionalization of Ketones Using Domino Reactions: A Strategy to Increase Chemoselectivity at the α-Carbon of Ketones

Molecules, Год журнала: 2025, Номер 30(5), С. 1114 - 1114

Опубликована: Фев. 28, 2025

A facile strategy to increase the chemoselectivity of domino reactions was proposed and successfully applied in α-functionalization ketones. The involved widening activation energy main reaction side through intermolecular interactions, thereby increasing reaction. In reaction, TMSCF3 acted as an excellent reagent which increased nucleophilicity DMF Van der Waals force reduced H2O a hydrogen bond. We found that can difference between using DFT calculations, greatly avoided formation by-products. recycled by rectification, average recovery rate 87.2%. XRD experiments, control experiments were performed support this mechanism. are confident has potential deliver significant practical advancements while simultaneously fostering broader innovation field synthesis.

Язык: Английский

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Construction of effective and recyclable non-precious metal coordination polymers and their multiple applications in water

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111165 - 111165

Опубликована: Апрель 1, 2025

Язык: Английский

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Self-assembly of decavanadate and Ni(HCO3)2 into nanoparticles anchored on carbon nitride for efficient photocatalytic Minisci-type alkylation

Journal of Catalysis, Год журнала: 2024, Номер unknown, С. 115789 - 115789

Опубликована: Окт. 1, 2024

Язык: Английский

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Reductive Coupling of N-Heteroarenes and 1,2-Dicarbonyls for Direct Access to γ-Amino Acids, Esters, and Ketones Using a Heterogeneous Single-Atom Iridium Catalyst

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(46), С. 31647 - 31655

Опубликована: Ноя. 7, 2024

Despite their significant importance, the challenges in direct and diverse synthesis of N-heterocyclic γ-amino acids/esters/ketones hamper exploration applications. Herein, by developing a multifunctional heterogeneous iridium single-atom catalyst composed silica-confined species boron-doped ZrO

Язык: Английский

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Iridium-catalyzed reductive β-alkylation of (iso)quinoline derivatives by an in situ enone-trapping strategy

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(22), С. 4516 - 4520

Опубликована: Янв. 1, 2024

Here, we report an iridium-catalyzed reductive β-alkylation of (iso)quinolinium salts with β-chloro ketones, which offers important complement to the synthesis functionalized (iso)tetrahydroquinolines.

Язык: Английский

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Divergent Synthesis of Cyclopropanated Tetrahydroquinolines by Tandem Functionalization of Quinoline Derivatives

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(11), С. 8131 - 8136

Опубликована: Май 16, 2024

Here, reported is a new method for divergent synthesis of functionalized tetrahydroquinolines (THQs), featuring biomedically interesting azabicyclo[4.1.0]heptane core, proceeding with mild conditions, good substrate and functionality tolerance, operational simplicity. Mechanistic studies suggest that the products are formed via carbonucleophilic 1,4-addition-induced dearomatization quinolinium salts intramolecular cyclopropanation α-halo ketones followed by α-nucleophilic addition different nucleophiles. The present work lays foundation to access N-heterocycles dearomative tandem functionalization azaarenes.

Язык: Английский

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Ir-Catalyzed Selective Reductive N-Formylation and Transfer Hydrogenation of N-Heteroarenes

Organometallics, Год журнала: 2024, Номер 43(18), С. 2097 - 2103

Опубликована: Сен. 3, 2024

Selective functionalization has numerous potential applications in the modification of bioactive compounds and pharmaceuticals. Herein, we advance a new approach for selective reductive N-formylation N-heteroarenes transfer hydrogenation using IrIII complexes as catalysts. The combination solvent, equivalent formic acid (FA), reaction temperature, iridium catalyst exerts high product selectivity, delivering divergent formations products excellent yields. In this process, FA can be employed not only hydrogen source but also reagent under different conditions.

Язык: Английский

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