Unlocking HFIP for Fluoroalkylation with Molecular Photoelectrocatalysis

Angewandte Chemie International Edition, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Despite the increasing interest in radical-based fluoroalkylation techniques, organofluorine compounds bearing partially fluorinated hexafluoroisopropyl group remain extremely scarce due to lack of appropriate reagents. Herein we report an unprecedented photoelectrocatalytic method for C-H hexafluoroisopropylation indoles and tryptophan peptides, utilizing readily available hexafluoro-2-propanol (HFIP) as reagent. In this process, HFIP is converted into radicals, enabling reactions. This study broadens potential applications molecular photoelectrocatalysis, highlighting its capacity enable transformations that are difficult accomplish through traditional electrochemical or photochemical approaches.

Язык: Английский

Direct Decarboxylative Phosphorylation of α‐Amino Acids via Continous‐Flow Electrochemistry

Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Comprehensive Summary Herein we present a novel electrochemical method for the direct decarboxylative phosphorylation of α‐amino acids to phosphonates, key structural element in various biologically active compounds. This bypasses need strong chemical oxidants and 2‐step processes involving preliminary conversions, making it more straightforward synthetic tool. Key success is establish microenvironment on anode surface an acidic solution facilitate selective anodic decarboxylation subsequent C–P formation. The electrosynthetic process continuous flow ensures benign conditions excellent scalability through production with parallel reactors.

Язык: Английский

Photoelectrochemistry-Promoted Ni-Catalyzed C–O Cross-Couplings

Precision Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Язык: Английский