Regulating Reactive Oxygen Species over M–N–C Single-Atom Catalysts for Potential-Resolved Electrochemiluminescence

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(17), С. 12197 - 12205

Опубликована: Апрель 17, 2024

The development of potential-resolved electrochemiluminescence (ECL) systems with dual emitting signals holds great promise for accurate and reliable determination in complex samples. However, the practical application such is hindered by inevitable mutual interaction mismatch between different luminophores or coreactants. In this work, first time, precisely tuning oxygen reduction performance M–N–C single-atom catalysts (SACs), we present a luminol ECL system employing endogenous dissolved O2 as coreactant. Using advanced situ monitoring theoretical calculations, elucidate intricate mechanism involving selective efficient activation through central metal species modulation. This modulation leads to controlled generation hydroxyl radical (·OH) superoxide (O2·–), which subsequently trigger cathodic anodic emission, respectively. well-designed Cu–N–C SACs, their moderate oxophilicity, enable simultaneous ·OH O2·–, thereby facilitating ECL. As proof concept, employed principal component analysis statistical method differentiate antibiotics based on output dual-potential signals. work establishes new avenue constructing platform single luminophore coreactant precise regulation active intermediates.

Язык: Английский

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When nanozymes meet deoxyribonucleic acid: Understanding their interactions and biomedical diagnosis applications

Deleted Journal, Год журнала: 2024, Номер 2(2)

Опубликована: Март 4, 2024

Abstract As emerging alternatives to natural enzymes, nanoscale materials featuring enzyme‐like catalytic behaviors (nanozymes) exhibit some attractive merits including robust activity, low cost, and easy‐to‐regulate performance. These have enabled them be intensively used in the biomedical field recent years. To remedy lack of selectivity most nanozymes, deoxyribonucleic acid (DNA) chains with specific recognition functions are utilized integrate nanozymes produce various nanozyme–DNA combinations via adsorption/desorption. In formed combinations, DNA component provides molecular/ionic role, nanozyme part offers response catalytically amplified signals, enabling detect analytes biomarkers selectively sensitively. highlight this interesting topic, here we made a critical review interactions between their applications biosensing disease diagnosis. First, strategies for conjugation onto surface were introduced briefly. Then, summarized detail, where flexible modulations activity by adsorption/desorption as well factors analyzed, potential impacts caused on characteristics pointed out. After that, typical DNA‐mediated modulation toxic ion sensing, health risk factor monitoring, diagnosis introduced. end, prospects combination presented, future challenges also discussed, attract more interest effort advance promising area.

Язык: Английский

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A ratiometric fluorescent probe based on the FRET platform for the detection of sulfur dioxide derivatives and viscosity

Analytica Chimica Acta, Год журнала: 2023, Номер 1288, С. 342184 - 342184

Опубликована: Дек. 27, 2023

Язык: Английский

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Bright luminescent Zn2GeO4:Mn NP/MXene hydrogel-based ECL biosensor for glioblastoma diagnosis

Talanta, Год журнала: 2024, Номер 276, С. 126214 - 126214

Опубликована: Май 6, 2024

Язык: Английский

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Electrochemical Detection of a Breast Cancer Biomarker with an Amine-Functionalized Nanocomposite Pt–Fe₃O₄–MWCNTs–NH₂ as a Signal-Amplifying Label

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(20), С. 25601 - 25609

Опубликована: Май 10, 2024

We report an ultrasensitive sandwich-type electrochemical immunosensor to detect the breast cancer biomarker CA 15-3. Amine-functionalized composite of reduced graphene oxide and Fe3O4 nanoparticles (MRGO-NH2) was used as sensing platform material modify electrodes. The nanocomposite comprising Pt (NPs) anchored on multiwalled carbon nanotubes (Pt-Fe3O4-MWCNTs-NH2) utilized a pseudoenzymatic signal-amplifying label. Compared oxide, MRGO-NH2 demonstrated higher signal. In Pt-Fe3O4-MWCNTs-NH2 label, provided substratum anchor abundant catalytic NPs. nanocomposites were thoroughly characterized using transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, scanning photoelectron spectroscopy. An electroanalytical study prevalidation carried out. exhibited exceptional capabilities in detecting 15-3, offering wider linear range 0.0005-100 U mL-1 lower detection limit 0.00008 mL-1. Moreover, designed showed good specificity, reproducibility, acceptable stability. sensor successfully applied analyze samples from patients, yielding reliable results.

Язык: Английский

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An electrochemiluminescence sensor based on Ag NPs amplifying PDDA-modified TbPO4:Ce NWs signal for sensitive detection of lincomycin

Bioelectrochemistry, Год журнала: 2024, Номер 158, С. 108702 - 108702

Опубликована: Апрель 2, 2024

Язык: Английский

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High-Efficient Electrochemiluminescence of DNA-Au Ag Nanoclusters with Au NPs@Ti₃C₂ as a Novel Coreaction Accelerator for Ultrasensitive Biosensing

Analytical Chemistry, Год журнала: 2024, Номер 96(33), С. 13727 - 13733

Опубликована: Авг. 7, 2024

In this work, an ultrasensitive electrochemiluminescence (ECL) biosensor was constructed based on DNA-stabilized Au Ag nanoclusters (DNA-Au NCs) as the efficient luminophore and NPs@Ti

Язык: Английский

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Ligand exchange induced porphyrin-lanthanide based self-enhanced electrochemiluminescence system with integrated emitter and reaction accelerator function for hypersensitive detection of kanamycin

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112777 - 112777

Опубликована: Янв. 1, 2025

Язык: Английский

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Co-reaction accelerator-encapsulated aggregation-induced electrochemiluminescence: Cascade-sensitized electron transfer and radiative transitions for Pro-GRP analysis

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112825 - 112825

Опубликована: Янв. 1, 2025

Язык: Английский

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Gold nanostars: From synthesis, properties to their application in food hazard detection

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160257 - 160257

Опубликована: Фев. 1, 2025

Язык: Английский

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