ACS Sensors,
Год журнала:
2024,
Номер
9(8), С. 3840 - 3847
Опубликована: Июль 31, 2024
Single-atom
nanozymes
(SANs)
have
become
a
breakthrough
in
atomically
precise
catalysis,
which
relies
on
the
catalytic
active
site
formed
by
single-atom
itself.
From
this
angle,
SANs
and
their
advantages
compared
to
natural
enzymes
as
well
spaces
for
application
are
emphasized.
The
outstanding
control
over
activities;
is
with
bulk
materials
enzymes.
structure
of
has
very
promising
potential
next
generation
biosensing
biomedical
devices
environmental
remediation.
Although
capabilities
high,
difficulties
still
arise.
specificity,
scalability,
biosafety,
catalysis
mechanisms
raise
additional
issues
that
require
further
research.
We
build
up
vision
perspectives
better
implementation
SANs,
designed
diagnostic
purposes,
improving
industrial
technologies,
creating
new
sustainable
technologies
food
processing
industry.
AI
machine
learning
systems
may
clarify
structure–performance
relationship
improved
material
process
selectivity.
future
promising,
addressing
these
challenges
leveraging
advancements
artificial
intelligence
science,
powerful
tools
future.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(34), С. 44361 - 44375
Опубликована: Авг. 20, 2024
The
global
spread
of
infectious
diseases
caused
by
pathogenic
bacteria
significantly
poses
public
health
concerns,
and
methods
for
sensitive,
selective,
facile
diagnosis
can
efficiently
prevent
deterioration
further
spreading
the
infections.
advent
nanozymes
has
broadened
spectrum
alternatives
diagnosing
bacterial
Compared
to
natural
enzymes,
exhibit
same
enzymatic
characteristics
but
offer
greater
economic
efficiency,
enhanced
durability,
adjustable
dimensions.
importance
early
infection
conventional
diagnostic
approaches
is
introduced.
Subsequently,
review
elucidates
definition,
properties,
catalytic
mechanism
nanozymes.
Eventually,
detailed
application
in
detecting
explored,
highlighting
their
utilization
as
biosensors
that
allow
accelerated
highly
sensitive
identification
infections
reflecting
on
potential
nanozyme-based
detection
a
point-of-care
testing
(POCT)
tool.
A
brief
summary
obstacles
future
perspectives
this
field
presented
at
conclusion
review.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(24), С. 10013 - 10020
Опубликована: Июнь 5, 2024
Traditional
methods
for
the
detection
of
pathogenic
bacteria
are
time-consuming,
less
efficient,
and
sensitive,
which
affects
infection
control
bungles
illness.
Therefore,
developing
a
method
to
remedy
these
problems
is
very
important
in
clinic
diagnose
diseases
guide
rational
use
antibiotics.
Here,
microfluidic
electrochemical
integrated
sensor
(MEIS)
has
been
investigated,
functionally
rapid,
efficient
separation
sensitive
bacteria.
Three-dimensional
macroporous
PDMS
Au
nanotube-based
electrode
successfully
assembled
into
modeling
microchip,
playing
functions
"3D
chaotic
flow
separator"
"electrochemical
detector,"
respectively.
The
3D
separator
enhances
turbulence
fluid,
achieving
an
excellent
capture
efficiency.
Meanwhile,
detector
provides
quantitative
signal
through
enzyme-linked
immunoelectrochemistry
with
improved
sensitivity.
could
isolate
Candida
albicans
(C.
albicans)
range
30–3,000,000
CFU
saliva
matrix
over
95%
efficiency
sensitively
detect
C.
1
h
oral
samples.
device
demonstrates
great
potential
diagnosis
candidiasis
also
applicable
other
ACS Central Science,
Год журнала:
2025,
Номер
11(2), С. 294 - 301
Опубликована: Янв. 15, 2025
Considerable
efforts
have
been
made
to
develop
microscale
multiplexing
strategies.
However,
challenges
remain
due
the
difficulty
in
deploying
functional
objects
and
decoding
high-density
signals
on
anisotropic
microcarriers.
Here,
we
report
a
microfluidic
method
fabricate
architecture-marked
particles
for
performing
designable
multiplexed
assays
label-free
manner.
By
controlling
fluid
assembly
rapid
in-air
cross-linking,
are
endowed
with
multiple
regions
unique
architecture
identifier.
The
marked
enables
an
addressing
mechanism
that
allows
profiling
of
embedded
by
mapping
well-defined
reference
onto
target
particle.
loading
analytes
interest,
such
as
molecular
probes
or
cells,
showed
potential
these
structurally
flexible
detecting
microRNAs
studying
cell
interactions.
represent
new
approach
single-entity
can
be
basis
exploring
more
advanced
applications.
