Cited by Designing small-molecule and macromolecule sensors for imaging redox-active transition metal signaling

Recent advances on DNAzyme for bioimaging, biosensing and cancer therapy DOI

Pei Sun,

Hongquan Gou,

Xinran Che

и другие.

Chemical Communications, Год журнала: 2024, Номер 60(78), С. 10805 - 10821

Опубликована: Янв. 1, 2024

DNAzymes, a class of single-stranded catalytic DNA with good stability, high activity, and easy synthesis, functionalization modification properties, have garnered significant interest in the realm biosensing bioimaging. Their integration fluorescent dyes or chemiluminescent moieties has led to remarkable bioimaging outcomes, while DNAzyme-based biosensors demonstrated robust sensitivity selectivity detecting metal ions, nucleic acids, proteins, enzyme activities, exosomes, bacteria microorganisms. In addition, by delivering DNAzymes into tumor cells, mRNA therein can be cleaved regulate expression corresponding which further propelled application cancer gene therapy synergistic therapy. This paper reviews strategies for screening attractive such as SELEX high-throughput sequencing, briefly describes amplification mainly include hairpin assembly (CHA), walker, hybridization chain reaction (HCR), origami, CRISPR-Cas12a, rolling circle (RCA), aptamers. applications bioimaging, biosensing, are also highlighted. Subsequently, possible challenges these practical pointed out, future research directions suggested.

Язык: Английский

Процитировано

Quantity of cu(II) ions in a copper pot by a DNAzyme-based fluorescent sensor DOI