Activatable Near-Infrared Fluorescence Probe for Hypochlorous Acid Detection in Early Diagnosis of Keloids
Analytical Chemistry,
Год журнала:
2024,
Номер
96(42), С. 16964 - 16970
Опубликована: Окт. 8, 2024
Keloids
represent
pathologic
conditions
characterized
by
the
presence
of
hyalinized
collagen
bundles
and
chronic
inflammatory
reactions.
Recently,
increased
ROS
production
disrupted
apoptosis
mechanisms
in
keloids
have
been
reported,
although
detailed
remain
unclear.
Herein,
we
developed
a
specific
fluorescence
probe,
Язык: Английский
A novel ultra-sensitive fluorescent probe for monitoring and imaging drug-induced/inhibited ferroptosis-mediated liver injury model via peroxynitrite fluctuations
T. Xiang,
Shuiling Lin,
Bingbing Tang
и другие.
Microchemical Journal,
Год журнала:
2025,
Номер
unknown, С. 112833 - 112833
Опубликована: Янв. 1, 2025
Язык: Английский
A Superoxide Anion Responsive and Self-Reporting Fluorescent H2s Donor for the Treatment of Diabetic Wound
Опубликована: Янв. 1, 2025
Язык: Английский
A superoxide anion responsive and self-reporting fluorescent H2S donor for the treatment of diabetic wound
Free Radical Biology and Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Screening Anti-Parkinson’s Disease Drugs in Living Mouse Brains via a Peroxynitrite-Activated Fluorescent Probe
Chemical & Biomedical Imaging,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Screening
anti-Parkinson's
disease
(PD)
drugs
at
in
vivo
brain
level
is
imperative
for
managing
PD
yet
currently
remains
unaccomplished.
Peroxynitrite
(ONOO–)
has
been
implicated
progression.
Thus,
developing
ONOO–-based
imaging
tools
anti-PD
drug
screening
holds
promise
early
prognosis
and
treatment
of
PD.
Consequently,
a
near-infrared
(NIR)
fluorescence
probe,
BOB-Cl-PN,
with
high
specificity,
good
sensitivity
(LOD
=
24
nM),
rapid
response
(<60
s),
was
devised
to
investigate
ONOO–
relationships.
Utilizing
NIR
imaging,
BOB-Cl-PN
effectively
monitored
fluctuations
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)-induced
cell
models,
establishing
cellular
throughput
(cHTS)
system
drugs.
In
live
animal
BOB-Cl-PN's
ability
penetrate
the
blood–brain
barrier
enabled
flux
mouse
brains.
Moreover,
served
as
an
contrast
potential
traditional
Chinese
medicines
therapy,
identifying
fisetin
having
best
therapeutic
index
among
10
medicines.
This
study
constructs
sensitive,
efficient
monitoring
dynamics
brains
provides
valuable
platform
Язык: Английский
Role of Peroxynitrite in the Pathogenesis of Parkinson’s Disease and Its Fluorescence Imaging-Based Detection
Biosensors,
Год журнала:
2024,
Номер
14(10), С. 506 - 506
Опубликована: Окт. 17, 2024
Parkinson's
disease
(PD)
is
the
second
most
common
neurodegenerative
disorder,
affecting
lives
of
millions
people
worldwide.
Although
mechanism
underlying
PD
pathogenesis
largely
undefined,
increasing
evidence
indicates
that
oxidative
and
nitrosative
stresses
play
a
crucial
role
in
occurrence
development.
Among
them,
stress
has
been
widely
acknowledged,
but
there
relatively
less
attention
given
to
stress,
which
mainly
derived
from
peroxynitrite.
In
present
review,
after
briefly
introducing
background
PD,
we
discuss
physiopathological
function
peroxynitrite
especially
highlight
how
overloaded
involved
pathogenesis.
Then,
summarize
currently
reported
fluorescence
imaging-based
detection
probes.
Moreover,
specifically
emphasize
probes
have
applied
research.
Finally,
propose
perspectives
on
develop
more
applicable
probe
leverage
it
for
theranostics.
Conclusively,
review
broadens
knowledge
pathological
context
sheds
light
utilize
strategies
detection.
Язык: Английский