Toxics,
Год журнала:
2024,
Номер
12(12), С. 926 - 926
Опубликована: Дек. 20, 2024
Organophosphorus
pesticides
are
the
most
extensively
utilized
agrichemicals
in
world.
They
play
a
crucial
role
regulating
crop
growth,
immunizing
against
pests,
and
improving
yields,
while
their
unregulated
residues
exert
serious
detrimental
effects
on
both
environment
human
health.
Many
efforts
have
been
made
world
to
monitor
organophosphorus
solve
issues
caused
by
them.
Nanozymes,
as
one
kind
of
enzyme
mimic
that
is
artificially
designed
simulate
function
natural
enzymes,
aroused
lot
attention
due
unparalleled
advantages.
Nanozymes
inherit
unique
properties
nanomaterials
catalytic
functions,
which
could
overcome
limitations
inherent
enzymes
great
versatile
adaptable
application
prospects.
This
review
presents
recent
advancement
synthesizing
multifunctional
nanozymes
with
enzymatic-like
activities
using
various
degrade
detect
pesticides.
It
mainly
encompasses
metal-based
nanozymes,
carbon-based
metal-organic-framework-based
single-atom-based
nanozymes.
Additionally,
this
paper
discusses
potential
novel
functional
environmental
materials.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 18, 2024
Multiple
enzyme-induced
cascade
catalysis
has
an
indispensable
role
in
the
process
of
complex
life
activities,
and
is
widely
used
to
construct
robust
biosensors
for
analyzing
various
targets.
The
immobilized
multi-enzyme
system
a
novel
biomimetic
strategy
that
immobilizes
enzymes
with
different
functions
stable
carriers
simulate
synergistic
multiple
biological
systems,
which
enables
high
stability
efficiency
enzymatic
catalysis.
Nanozymes,
type
nanomaterial
intrinsic
enzyme-like
characteristics
excellent
stabilities,
are
also
applied
instead
achieving
better
catalytic
performance
reaction
stability.
Due
good
stability,
reusability,
remarkably
efficiency,
multi-enzyme/nanozyme
systems
show
distinct
advantages
promoting
signal
transduction
amplification,
thereby
attracting
vast
research
interest
biosensing
applications.
This
review
focuses
on
progress
recent
years.
construction
approaches,
factors
affecting
applications
sensitive
discussed
detail.
Further,
their
challenges
outlooks
future
study
provided.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(36), С. 14508 - 14515
Опубликована: Авг. 23, 2024
An
ultrasensitive
self-powered
biosensor
is
constructed
for
miRNA-21
detection
based
on
Au
nanoparticles
@
Pd
nanorings
(Au
NPs@Pd
NRs)
and
catalytic
hairpin
assembly
(CHA).
The
NRs
possess
excellent
electrical
conductivity
to
improve
the
electron
transfer
rate
show
good
elimination
of
byproduct
H2O2
assist
glucose
oxidase
(GOD)
catalyze
glucose;
CHA
used
as
an
amplification
strategy
effectively
enhance
sensitivity
biosensor.
To
further
amplify
output
signal,
a
capacitor
integrated
into
With
multiple
signal
strategies,
possesses
linear
range
0.1–10–4
fM
lower
limit
(LOD)
0.032
(S/N
=
3).
In
addition,
as-prepared
displays
potential
applicability
in
assay
toward
human
serum
samples.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 13, 2024
As
novel
multifunctional
materials
that
merge
enzyme-like
capabilities
with
the
distinctive
traits
of
nanomaterials,
nanozymes
have
made
significant
strides
in
interdisciplinary
research
areas
spanning
science,
bioscience,
and
beyond.
This
article,
for
first
time,
employed
bibliometric
methods
to
conduct
an
in-depth
statistical
analysis
global
demonstrate
progress,
hotspots
trends.
Drawing
on
data
from
Web
Science
Core
Collection
database,
we
comprehensively
retrieved
publications
2004
2024.
The
burgeoning
interest
across
various
nations
indicated
a
growing
widespread
trend.
article
further
systematically
elaborated
activities,
matrix,
properties,
catalytic
mechanisms
applications
nanozymes,
field
encounters
challenges.
Despite
notable
requires
deeper
exploration
guide
future
directions.
harbors
broad
potential
developments,
promising
impact
aspects
technology
society.
Inorganic Chemistry,
Год журнала:
2024,
Номер
63(35), С. 16442 - 16450
Опубликована: Авг. 22, 2024
Colorimetry
based
on
the
bioenzyme
inhibition
strategy
holds
promising
application
prospects
in
field
of
organophosphorus
pesticide
(OPs)
detection.
However,
overcoming
challenges
high
cost
and
low
stability
bioenzymes
remains
crucial.
In
this
study,
we
successfully
synthesized
a
peroxidase
vanadium-based
metal-organic
framework
(MOF)
nanozyme
named
MIL-88B(V)
employed
its
mediated
bioenzyme-free
colorimetric
for
direct
OPs
The
experimental
results
demonstrated
that
exhibited
remarkable
affinity
catalytic
rate.
When
target
is
added,
it
can
be
anchored
MOF
surface
through
V-O-P
bond,
effectively
inhibiting
MOF's
activity.
Subsequently,
leveraging
advantages
smartphones
such
as
convenience,
speed,
sensitivity,
developed
paper
sensor
integrated
into
smartphone
efficient
as-designed
nanozyme-based
assay
presented
herein
offer
notable
advantages,
including
affordability,
stability,
wide
adaptability,
cost,
accuracy
detecting
OPs,
thus
providing
versatile
analytical
approach
real
sample
analysis
allowing
new
applications
V-based
nanozymes.
Molecules,
Год журнала:
2025,
Номер
30(1), С. 187 - 187
Опубликована: Янв. 5, 2025
Compared
to
natural
enzymes,
the
development
of
efficient
artificial
simulated
such
as
those
based
on
bimetallic
materials
with
high
catalytic
activity
and
good
stability,
is
an
important
way
until
now.
Herein,
we
employed
ZnCo2O4
microspheres
carriers
synthesize
Pt-doped
composites
different
amounts
using
a
one-pot
method.
The
morphology
structure
synthesized
were
characterized
XRD,
SEM,
BET,
FT-IR,
XPS,
Zeta
potential
techniques.
It
was
found
that
Pt0
adhered
well
surface
microspheres,
12.5%
Pt
doped
ratio
exhibiting
abundant
oxygen
vacancies,
excellent
substrate
affinity,
peroxidase-like
activity.
Using
fluorescent
probes
electrochemical
methods,
mechanism
has
been
explored
Pt@ZnCo2O4
can
accelerate
electron
transfer
between
H2O2
3,3',5,5'-tetramethylbenzidine
(TMB).
Based
optimal
loading
Pt@ZnCo2O4,
colorimetric
sensor
for
visual
detection
L-cysteine
(L-Cys)
constructed,
wide
linear
range
0.1~50
µM
low
limit
0.0163
µM.
possesses
selectivity,
reusability,
usage
which
be
applied
determination
L-Cys
in
health
product
capsules
recovery
rates
96.9%~103.7%
RSD
1.07%~6.50%.
This
work
broadens
application
prospects
spinel
field
biological
analysis
also
provides
inspiration
new
enzymes.
Due
to
the
simultaneous
activation
of
hydrogen
peroxide
(H2O2)
and
oxygen,
Ru
nanocrystals
exhibit
inherent
peroxidase-
oxidase-like
activities,
thereby
limiting
their
extensive
application
in
biosensing.
Phase
engineering
holds
great
promise
for
enhancing
catalytic
activity
selectivity
but
remains
a
challenge.
Here,
highly
active
with
metastable
face-centered
cubic
(fcc)
structure
were
successfully
synthesized
via
facile
wet-chemical
method
followed
by
an
etching
step,
enabling
selective
H2O2
demonstrating
promising
peroxidase-like
activity.
Compared
thermodynamically
favored
hexagonal
close-packed
nanocrystals,
resultant
fcc
shows
over
5-fold
enhancement
maximum
reaction
velocity
catalysis,
while
its
performance
exhibits
minor
decline,
indicating
transition
from
multienzyme
specificity.
Theoretical
calculations
reveal
that
phase
transformation
not
only
results
upward
shift
d-band
center
enhance
adsorption
also
regulates
O–O
bonding
strength
achieve
activation.
As
proof
concept,
colorimetric
sensor
based
on
was
constructed,
achieving
accurate
sensitive
detection
organophosphorus
pesticides.
This
work
offers
prospects
highlights
significance
Biosensors,
Год журнала:
2025,
Номер
15(2), С. 118 - 118
Опубликована: Фев. 17, 2025
Acetylcholinesterase
inhibitors
(AChEIs),
particularly
donepezil,
are
commonly
used
to
treat
mild-to-moderate
Alzheimer's
disease
(AD).
However,
drug
accumulation
during
long-term
use
could
change
AChE
activity
and
content,
leading
peripheral
side
effects
prompting
medication
discontinuation.
there
a
lack
of
methods
simultaneously
determine
the
content
catalytic
AChE.
By
using
phosphatidylinositol-specific
phospholipase
C
strip
from
erythrocyte
surfaces,
we
developed
novel
method
combining
surface
plasmon
resonance
fluorescence
detection
for
simultaneous
activity,
producing
stable,
reliable,
accurate
results.
The
established
determination
range
spans
263.37
ng/mL
3000
(4.05
nM
46.15
nM)
concentration,
39.02
mU/mL
1000
activity.
Compared
traditional
methods,
this
approach
simplifies
operations,
reduces
time,
expands
dynamic
range,
lowers
limits,
potentially
advancing
AChE-related
research
supporting
clinical
diagnostics
development.
