A Non-Solvatochromic Fluorescent Probe for Imaging of Lipid Droplets in Live Cells and Tissues

Talanta, Год журнала: 2025, Номер 290, С. 127805 - 127805

Опубликована: Фев. 22, 2025

Язык: Английский

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A Dual-Responsive Fluorescent Probe for Cancer Diagnostics via Simultaneous Detection of H2S and hNQO1

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137682 - 137682

Опубликована: Март 1, 2025

Язык: Английский

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New AIE Emitters from the Unexpected Boron Tribromide/Boron Trichloride‐mediated Cyclization Reaction and Application for Fluorescence Imaging of Lipid Droplets

Aggregate, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

ABSTRACT The aberrant behavior of lipid droplets (LDs) is often indicative cellular dysfunction, which may contribute to the development a range diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and atherosclerosis (AS). Consequently, there an urgent need develop fluorescence probes targeting LDs monitor progression disease. In this study, unanticipated one‐pot boron tribromide (BBr₃)/boron trichloride (BCl₃)‐promoted cyclization reaction was discovered, yielding bromo‐/chloro‐substituted triphenylamine (TPA) derivative ( TPA‐Br / TPA‐Cl ). successfully transformed into new TPA‐containing donor‐acceptor (D–A) molecules show typical aggregation induced emission (AIE) property. Among these AIE emitters, TPA‐N shows most promising specificity, lowest toxicity best photo‐stability. Ex vivo studies further demonstrate that can be used image fatty AS plaque quickly effectively.

Язык: Английский

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A polarity-sensitive fluorescent probe for visualizing lipid droplets in ferroptosis, cuproptosis, and autophagy

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер 332, С. 125854 - 125854

Опубликована: Фев. 3, 2025

Язык: Английский

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Lipid Droplet-Targeting Carbonized Polymer Dots for Intracellular Polarity Visualization under Wash-Free Conditions

Analytica Chimica Acta, Год журнала: 2025, Номер 1346, С. 343790 - 343790

Опубликована: Фев. 10, 2025

Язык: Английский

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Precise diabetes visualization designed for lipid droplet-targeted polarity-sensitive fluorescent probe

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113018 - 113018

Опубликована: Фев. 1, 2025

Язык: Английский

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Dual-responsive near-infrared fluorescent probe for monitoring viscosity and mitochondria-generated peroxynitrite-induced lipid droplet migration in live cells and non-alcoholic fatty liver

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137580 - 137580

Опубликована: Март 1, 2025

Язык: Английский

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Ratiometric Detection of Carboxylesterase In Vitro and In Vivo via a BODIPY‐Styryl Platform

Luminescence, Год журнала: 2025, Номер 40(3)

Опубликована: Март 1, 2025

Hepatocellular carcinoma (HCC) is a highly aggressive liver malignancy and the main form of cancer. Early diagnosis treatment HCC can effectively reduce mortality. Carboxylesterase (CE) abundantly present in tissue, which shows promise as an innovative diagnostic biomarker for HCC. Herein, we designed synthesized novel fluorescent probe BDPPh-CES, based on boron dipyrromethenes (BODIPY)-styryl framework, ratiometric detection CE. Upon interaction with CEs, demonstrates characteristic fluorescence emission red shift, completing reaction within 30 min. Notably, BDPPh-CES maintains specificity against acetylcholinesterase (AChE) various biological species, while exhibiting robust performance across physiological pH conditions. Comprehensive mechanistic investigations, combining high-resolution mass spectrometry (HRMS) analysis, density functional theory (DFT) computational studies, molecular docking simulations, provided insights into binding sensing mechanisms. The high sensitivity low cytotoxicity facilitated real-time imaging CEs at cellular level, successfully distinguishing elevated CE expression Hepa 1-6 hepatic cancer cells over AML 12 normal hepatocytes. Further validation through vivo experiments confirmed liver-specific accumulation efficient capabilities. This research presents approach monitoring, potential implications early therapeutic management CE-associated disorders such

Язык: Английский

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Molecular engineering of a D-A-type fluorescent probe with AIE properties for c-MYC G-Quadruplex DNA

Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112814 - 112814

Опубликована: Апрель 1, 2025

Язык: Английский

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Fluorescence imaging‐guided lipid droplets‐localized photodynamic therapy

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Abstract Photodynamic therapy (PDT) has emerged as a promising strategy for cancer treatment due to its non‐invasive nature and high specificity toward malignant tissues. In recent years, variety of protocols have been proposed improve the PDT efficacy, which organelle‐targeted is supposed be quite promising. Particularly, lipid droplets (LDs)‐localized attracts lot interest inherent advantages such abundant LDs in cells their close relation with ferroptosis. This review provides comprehensive summary advancements LDs‐localized photosensitizers (PSs) according chemical structures functions. Especially, these PSs are featured fluorescence emission, thereby facilitating an imaging‐guided phototherapy. The highlights cytocidal actions PSs, cell death pathway cytotoxicity. Finally, some unresolved issues challenges this domain will discussed.

Язык: Английский

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