Sensors and Actuators B Chemical, Год журнала: 2024, Номер unknown, С. 137160 - 137160
Опубликована: Дек. 1, 2024
Язык: Английский
Analytica Chimica Acta, Год журнала: 2025, Номер unknown, С. 343715 - 343715
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Microchemical Journal, Год журнала: 2024, Номер 207, С. 112086 - 112086
Опубликована: Ноя. 13, 2024
Язык: Английский
Процитировано
6
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 3, 2025
The rational design of efficient hydroxyl intermediate (*OH) adsorption catalysts for dopamine electrooxidation still faces a major challenge. To address this challenge, CeO2-loaded CuO catalyst inspired by the f-p-d orbital hybridization strategy is designed to achieve *OH and improve oxidation. experimental results theoretical calculations demonstrate that regulates electron distribution at Ce–O–Cu interface, which facilitates transfer optimizes *OH, thereby promoting electrochemical sensor exhibits excellent catalytic activity sensitivity, reaching limit detection 3.22 nM. This work provides promising approach designing highly active electrocatalysts with
Язык: Английский
Процитировано
0
Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112688 - 112688
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Electrochimica Acta, Год журнала: 2025, Номер unknown, С. 145708 - 145708
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 26, 2025
Homogeneous analysis techniques offer several advantages as alternatives to heterogeneous immunoassays, such simplicity and rapidity. In this study, a visual homogeneous immunoassay without labeling process was developed based on target-induced steric hindrance regulate competitive recognition mechanism. Specifically, the analyte concentration varies, change of microenvironment could affect Cu2+ by signal probes. Herein, taking anticyclic citrullinated peptide antibody (anti-CCP) an example, method verified. can bind histidine (His), well Cyclic containing His served capture antigen, fluorescence both CdTe quantum dots calcein be quenched Cu2+. Then, quenching effect regulated hindrance, so that anti-CCP realized. The limit detection low 0.002 0.01 U/mL in mode red, green, blue (RGB) mode, respectively. Furthermore, clinical practicality validated through 46 samples, including rheumatoid arthritis patients (n = 28) healthy donors 18), with assay demonstrating sensitivity specificity 96.4% 88.9%, Indeed, results were consistent those electrochemiluminescence immunoassays digital radiography images. Overall, shows great potential for application offers universal template label-free immunoassay.
Язык: Английский
Процитировано
0
Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112991 - 112991
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
The Science of The Total Environment, Год журнала: 2025, Номер 970, С. 179032 - 179032
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
ACS Pharmacology & Translational Science, Год журнала: 2025, Номер 8(4), С. 1028 - 1049
Опубликована: Март 12, 2025
The development of precise and efficient delivery systems is pivotal for advancing CRISPR/Cas9 gene-editing technologies, particularly therapeutic applications. Engineered metal-organic frameworks (MOFs) have emerged as a promising class inorganic nonviral vectors, offering unique advantages such tunable porosity, high cargo-loading capacity, biocompatibility. This review explores the design application MOF-based nanoplatforms tailored targeted components, aiming to enhance precision efficiency. By incorporating stimuli-responsive linkers bioactive ligands, these MOFs enable controlled release payloads at target site. Comparative discussions demonstrate superior performance over conventional in terms stability, transfection efficiency, reduced off-target effects. Additionally, intracellular trafficking mechanisms potential platforms preclinical models are discussed. These findings highlight transformative overcoming challenges associated with immunogenicity cytotoxicity, paving way their medicine. provides blueprint integration nanotechnology genome editing, frontier systems.
Язык: Английский
Процитировано
0
ACS Measurement Science Au, Год журнала: 2025, Номер unknown
Опубликована: Март 19, 2025
Although the role of kynurenic acid (KYNA) is not yet fully understood, recent research has implicated this tryptophan (Trp) metabolite as a significant biomarker in neurodegenerative diseases. In study, we developed an immunosensor platform based on self-assembled polyelectrolyte multilayers (PEMs), employing enzyme-labeled immunoreagent competitive displacement format that requires only single wash step. This enables detection KYNA and Trp with limits (LOD) 9 pg/mL 1.2 ng/mL, respectively. Results validated by traditional ELISA methods indicated elevated levels increased KYNA/Trp ratio cerebrospinal fluid (CSF) Alzheimer's patients compared to controls, consistent previous findings. Additionally, can be readily adapted detect other neuroactive metabolites substituting specific immunoreagents, supporting flexible profile-based approach. could serve rapid, cost-effective clinical tool for monitoring neurological psychiatric disorders, potentially advancing therapeutic strategy development.
Язык: Английский
Процитировано
0