Supramolecular Adhesive Hydrogels for Tissue Engineering Applications

Chemical Reviews, Год журнала: 2022, Номер 122(6), С. 5604 - 5640

Опубликована: Янв. 13, 2022

Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the loss or failure of an organ tissue, with aim restore dysfunctional tissues enhance life expectancy. Supramolecular adhesive hydrogels are emerging as appealing materials for tissue applications owing their favorable attributes such tailorable structure, inherent flexibility, excellent biocompatibility, near-physiological environment, dynamic mechanical strength, particularly attractive self-adhesiveness. In this review, key design principles various supramolecular strategies construct comprehensively summarized. Thereafter, recent research progress regarding applications, including primarily dermal repair, muscle bone neural vascular oral corneal cardiac fetal membrane hepatic gastric systematically highlighted. Finally, scientific challenges remaining opportunities underlined show full picture hydrogels. This review expected offer comparative views critical insights inspire more advanced studies on pave way different fields even beyond applications.

Язык: Английский

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Structural and biological engineering of 3D hydrogels for wound healing

Bioactive Materials, Год журнала: 2022, Номер 24, С. 197 - 235

Опубликована: Дек. 23, 2022

Chronic wounds have become one of the most important issues for healthcare systems and are a leading cause death worldwide. Wound dressings necessary to facilitate wound treatment. Engineering may substantially reduce healing time, risk recurrent infections, disability costs associated. In path engineering an ideal dressing, hydrogels played role. Hydrogels 3D hydrophilic polymeric structures that can provide protective barrier, mimic native extracellular matrix (ECM), humid environment. Due their advantages, (with different architectural, physical, mechanical, biological properties) been extensively explored as dressing platforms. Here we describe recent studies on applications with strong focus interplay between fabrication method used performance achieved. Moreover, review categories additives which enhance regeneration using hydrogel dressings. Hydrogel promises generation smart solutions solve this pressing problem, enabling key functionalities such bacterial growth inhibition, enhanced re-epithelialization, vascularization, improved recovery tissue functionality, overall, accelerated effective healing.

Язык: Английский

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Multi-crosslinking hydrogels with robust bio-adhesion and pro-coagulant activity for first-aid hemostasis and infected wound healing

Bioactive Materials, Год журнала: 2022, Номер 16, С. 388 - 402

Опубликована: Март 9, 2022

Язык: Английский

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Engineering Smart Composite Hydrogels for Wearable Disease Monitoring

Nano-Micro Letters, Год журнала: 2023, Номер 15(1)

Опубликована: Апрель 15, 2023

Growing health awareness triggers the public's concern about problems. People want a timely and comprehensive picture of their condition without frequent trips to hospital for costly cumbersome general check-ups. The wearable technique provides continuous measurement method monitoring by tracking person's physiological data analyzing it locally or remotely. During process, different kinds sensors convert signals into electrical optical that can be recorded transmitted, consequently playing crucial role in techniques. Wearable application scenarios usually require possess excellent flexibility stretchability. Thus, designing flexible stretchable with reliable performance is key technology. Smart composite hydrogels, which have tunable properties, mechanical biocompatibility, multi-stimulus sensitivity, are one best sensitive materials monitoring. This review summarizes common synthetic optimization strategies smart hydrogels focuses on current field

Язык: Английский

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Chitosan, alginate, hyaluronic acid and other novel multifunctional hydrogel dressings for wound healing: A review

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 240, С. 124321 - 124321

Опубликована: Апрель 3, 2023

Язык: Английский

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Antimicrobial/Biocompatible Hydrogels Dual-Reinforced by Cellulose as Ultrastretchable and Rapid Self-Healing Wound Dressing

Biomacromolecules, Год журнала: 2021, Номер 22(4), С. 1654 - 1663

Опубликована: Март 3, 2021

Hydrogels as a wound dressing, integrated with ultrastretchability, rapid self-healing, and excellent antimicrobial activity, are in high demand, particularly for joint skin healing. Herein, multifunctional ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel matrix that synergized or dual-reinforced dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) nanofibers (CNF). Moreover, neomycin (NEO), an aminoglycoside antibiotic groups, incorporated into the network both antibacterial agent cross-linker. The dynamic reversible borate ester linkages hydrogen bonds between OCMC-DA, PVA, CNF, along cross-linking imine NEO endowed self-healing ability stretchability (3300%). as-reinforced networks enhanced mechanical properties of hydrogels significantly. More remarkably, improved biodegradability biocompatibility is pH-responsive effective against broad spectrum bacteria, which attributed to controllable release steady availability on location. Overall, reliable holds significant promise dressing material

Язык: Английский

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A review of the properties and applications of bioadhesive hydrogels

Polymer Chemistry, Год журнала: 2021, Номер 12(26), С. 3721 - 3739

Опубликована: Янв. 1, 2021

Due to their outstanding properties, bioadhesive hydrogels have been extensively studied by researchers in recent years.

Язык: Английский

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Physical dynamic double-network hydrogels as dressings to facilitate tissue repair

Nature Protocols, Год журнала: 2023, Номер 18(11), С. 3322 - 3354

Опубликована: Сен. 27, 2023

Язык: Английский

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Architecting polyelectrolyte hydrogels with Cu-assisted polydopamine nanoparticles for photothermal antibacterial therapy

Materials Today Bio, Год журнала: 2022, Номер 15, С. 100264 - 100264

Опубликована: Апрель 20, 2022

Polydopamine nanoparticles (PDA NPs) are an appealing biomimetic photothermal agent for antibacterial treatment because of their long-term safety, excellent photostability, accessible manufacturing, and good biodegradability. However, the low conversion efficiency (PCE) PDA NPs requires high-power near-infrared light irradiation, which severely restricts practical application. In this work, PDA@Cu were fabricated by growing Cu in situ on surface then introduced into a polyelectrolyte hydrogel precursor (cationic polyethyleneimine/anionic pectin, named as CPAP). The formulated platform possessed high PCE (55.4%), almost twice much pure (30.8%). Moreover, designed CPAP/PDA@Cu captured killed some bacteria electrostatic adsorption, helped enhance performance. As expected, formed that combined advantageous features (high PCE) CPAP matrix (inherent activity preventing aggregation) can efficiently kill both vitro vivo under help laser irradiation. Taken together, study offers promising strategy constructing facile safe PDA-based therapy.

Язык: Английский

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Construction of multifunctional wound dressings with their application in chronic wound treatment

Biomaterials Science, Год журнала: 2022, Номер 10(15), С. 4058 - 4076

Опубликована: Янв. 1, 2022

Multifunctional wound dressings or smart with pro-angiogenic function, antibacterial properties, anti-inflammatory/antioxidant activity and tissue adhesion for chronic repair.

Язык: Английский

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