Crystal Growth & Design,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 21, 2024
Bisphosphonates
(BPs)
are
an
important
treatment
for
osteoporosis
and
bone
metastases
due
to
their
low
toxicity,
high
thermostability,
the
ability
inhibit
resorption.
Notably,
BPs
like
alendronate,
which
contain
a
primary
amine
group,
exhibit
potent
antiresorptive
antiangiogenic
properties.
Recent
studies
have
focused
on
enhancing
BP
properties
by
incorporating
bioactive
metals
increase
therapeutic
potential.
Here,
we
describe
synthesis
physicochemical
of
new
silver
etidronate
alendronate
salts.
Our
research
demonstrates
potential
bisphosphonate
complexes
in
promoting
osteoblast
viability
while
exhibiting
significant
antimicrobial
activity.
Moreover,
silver/sodium
alendronates
turned
out
be
rare
examples
molecular
solid
solutions
that
allow
adjustment
concentration
potentially
cytotoxic
cations
within
obtained
compounds.
European Journal of Theoretical and Applied Sciences,
Год журнала:
2024,
Номер
2(1), С. 546 - 565
Опубликована: Янв. 1, 2024
This
research
looks
at
how
the
growth
of
cities
and
industries
affects
levels
heavy
metals
in
soil,
which
can
impact
people's
health.
We
find
out
where
pollution
comes
from,
such
as
factories,
car
fumes,
improper
waste
disposal,
by
reviewing
existing
studies.
use
different
methods
to
test
soil
for
study
exposure
these
urban
areas
The
evidence
shows
a
connection
between
high
city
health
problems
like
breathing
issues,
brain
disorders,
overall
toxicity
body.
also
explore
get
into
human
body,
highlighting
importance
understanding
they
are
available
ways
people
exposed.
To
deal
with
polluted
soils,
we
look
manage
suggest
sustainable
reduce
metal
pollution.
Our
discoveries
add
what
know
about
environmental
health,
emphasizing
need
actions
protect
residents.
Ultimately,
this
aims
give
important
information
insights
policymakers,
planners,
public
officials
managing
lessening
risks
linked
contamination
soils.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 24, 2025
The
current
study
used
sustainable
and
green
approaches
to
convey
polymer
composites
with
desired
optical
properties.
extracted
tea
dye
(GTD)
enriched
ligands
was
synthesize
zinc
metal
complexes.
Green
chitosan
biopolymer
incorporated
synthesized
complex
using
casting
technique
deliver
improved
FTIR-ATR
identify
the
functional
groups
of
GTD,
pure
CS,
surrounding
complex.
Distinguished
ATR
bands
were
observed
in
spectra,
such
as
OH,
C
=
O,
NH
ascribed
various
polyphenols.
compared
GDT
established
that
is
crucial
capturing
cations
producing
Zn2+-metal
broadness
CS-based
inserted
Zn2+-
confirms
strong
interaction
among
components
composites.
XRD
achievements
confirm
CS
films
different
concentrations
transferred
an
amorphous
composite.
pattern
composite
establishes
scarified
crystalline
phases
chitosan.
Linear
properties
absorption,
refractive
index
(n),
dielectric
parameters
improved.
absorption
edge
composite's
shifted
lower
photon
energies.
Various
models
determine
band
gap.
gap
drops
from
$$\:5.3\:to\:\approx\:\:1.5\:\text{e}\text{V}$$
when
loaded
a
36%
Spitzer-Fan
method
get
constant,
Drude
Lorentz
oscillator
model
calculate
vital
parameters,
including
N/m*,
τ,
µopt.
W-D
single
Eo
Ed
parameters.
values
moments
(M−1
M−3)
calculated
help
model.
oscillator's
strength
(
$$\:{S}_{0}$$
)
wavelength
$$\:{\lambda\:}_{0}$$
determined
via
Sellmeier
linear
index.
first-order
nonlinear
$$\:{\chi\:}^{\left(1\right)}$$
),
second-order
non-linear
$$\:{\chi\:}^{\left(2\right)}$$
third-order
susceptibility
$$\:{\chi\:}^{\left(3\right)}$$
for
all
films.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Янв. 28, 2025
Introduction
Osteoarthritis
(OA)
is
a
degenerative
disease
of
the
joints
characterized
by
cartilage
degradation
and
synovial
inflammation.
Due
to
complex
pathogenesis
OA,
multifaceted
therapies
that
modulate
inflammatory
immune
microenvironmental
disturbances
while
promoting
regeneration
are
key
control
progression
OA.
Methods
Herein,
multifunctional
nanoparticle
(DIC/Mg-PDA
NPs)
was
constructed
successfully
metal
chelation
effect
between
Mg
2+
catecholamine
bond
from
dopamine,
followed
amidation
with
diclofenac
(DIC),
which
then
prepared
into
an
injectable
hydrogel
microsphere
(DIC/Mg-PDA@HM)
immune-regulating
cartilage-repairing
abilities
through
microfluidic
technology
for
treatment
osteoarthritis.
Results
discussion
The
sustained
release
composite
microspheres
achieved
regulation
converting
macrophages
M1
M2
promoted
differentiation
BMSCs.
Moreover,
enhanced
DIC
polydopamine
(PDA)
effectively
downregulated
factors,
finally
OA
therapy.
In
addition,
in
vivo
MRI
tissue
section
staining
model
proved
significant
efficacy
on
conclusion,
these
novel
demonstrated
promising
prospect
multidisciplinary
repairing
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 18
Опубликована: Янв. 31, 2025
Advancements
in
tissue
regeneration,
particularly
bone
regeneration
is
key
area
of
research
due
to
potential
novel
therapeutic
approaches.
Efforts
reduce
reliance
on
autologous
and
allogeneic
grafts
have
led
the
development
biomaterials
that
promote
synchronized
controlled
healing.
However,
use
growth
factors
limited
by
their
short
half-life,
slow
penetration,
large
molecular
size
toxicity.
These
suggest
traditional
delivery
methods
may
be
inadequate
hence,
address
these
challenges,
new
strategies
are
being
explored.
approaches
include
bioactive
substances
within
advanced
systems
enable
precise
spatiotemporal
control.
Dual-release
composite
scaffolds
offer
a
promising
solution
reducing
need
for
multiple
surgical
interventions
simplifying
treatment
process.
allow
sustained
drug
release,
enhancing
repair
while
minimizing
drawbacks
conventional
methods.
This
review
explores
various
dual-drug
release
systems,
discussing
modes
action,
types
drugs
used
mechanisms
improve
regeneration.
Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(4)
Опубликована: Апрель 1, 2025
ABSTRACT
Metal
ion‐assisted
hydrogels
are
of
growing
interest
because
their
excellent
mechanical
properties,
fast
recovery,
and
self‐healing
ability.
However,
affording
all
these
properties
in
a
single
polymeric
framework
is
very
challenging.
This
paper
presents
facile
one‐pot
synthesis
Zn
2+
coordinated
by
using
acrylic
acid
acrylamide
monomer
as
precursors.
Special
emphasis
has
been
placed
on
the
types
zinc
salt
that
have
not
studied
before.
Zinc
coordination
provides
hydrogel
with
prominent
strength,
toughness,
stretchability,
without
any
stimulation,
due
to
numerous
entanglements
chains.
Rheology
studies
demonstrate
various
salts
used
for
functional
groups
could
influence
gels
different
extents.
The
highest
potential
exhibited
MGel‐ZnCl
2
(up
90%
recovery)
while
those
MGel,
MGel‐Zn(NO
3
)
,
MGel‐ZnSO
4
60%,
62%,
64%,
respectively.
Dynamic
analysis
reveals
higher
compressive
strength
(0.86
MPa)
when
compared
other
samples
viz.
MGel
(0.48
MPa),
(0.49
(0.45).
On
hand,
offers
remarkable
strain
stability
at
ε
%
=
66.63
surpassing
(
11.05),
55),
17).
Biomacromolecules,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Hyaluronic
acid
(HA)
is
a
biomedically
relevant
polymer
widely
explored
as
component
of
hydrogels.
The
prevailing
approaches
for
cross-linking
HA
into
hydrogels
require
chemically
modifying
the
polymer,
which
can
increase
processing
steps
and
complicate
biocompatibility.
Herein,
we
demonstrate
an
alternative
approach
to
cross-link
that
eliminates
need
chemical
modifications
by
leveraging
interactions
between
metal
cations
negatively
charged,
ionizable
functional
groups
on
HA.
We
be
cross-linked
with
bivalent
Mn(II),
Fe(II),
Co(II),
Ni(II),
Cu(II),
Zn(II),
Pd(II),
notably
Mg(II).
Using
Mg(II)
model,
show
ion-HA
hydrogel
rheological
properties
tuned
altering
molecular
weight
concentrations
ions,
NaOH,
Mg(II)-HA
showed
potential
self-healing
stimulus
response.
Our
findings
lay
groundwork
developing
new
class
HA-based
use
in
biomedical
applications
beyond.
