Advances in medical polyesters for vascular tissue engineering
Discover Nano,
Год журнала:
2024,
Номер
19(1)
Опубликована: Авг. 8, 2024
Abstract
Blood
vessels
are
highly
dynamic
and
complex
structures
with
a
variety
of
physiological
functions,
including
the
transport
oxygen,
nutrients,
metabolic
wastes.
Their
normal
functioning
involves
close
coordinated
cooperation
cells.
However,
adverse
internal
external
environmental
factors
can
lead
to
vascular
damage
induction
various
diseases,
atherosclerosis
thrombosis.
This
have
serious
consequences
for
patients,
there
is
an
urgent
need
innovative
techniques
repair
damaged
blood
vessels.
Polyesters
been
extensively
researched
used
in
treatment
disease
due
their
excellent
mechanical
properties,
adjustable
biodegradation
time,
biocompatibility.
Given
high
complexity
tissues,
it
still
challenging
optimize
utilization
polyesters
repairing
Nevertheless,
they
considerable
potential
tissue
engineering
range
applications.
summary
reviews
physicochemical
properties
polyhydroxyalkanoate
(PHA),
polycaprolactone
(PCL),
poly-lactic
acid
(PLA),
poly(lactide-co-glycolide)
(PLGA),
focusing
on
unique
applications
engineering.
be
prepared
not
only
as
3D
scaffolds
alternative
grafts,
but
also
forms
such
microspheres,
fibrous
membranes,
nanoparticles
deliver
drugs
or
bioactive
ingredients
Finally,
anticipated
that
further
developments
will
occur
near
future,
facilitate
wider
application
these
materials
Язык: Английский
Electrospinning of Biocompatible Nanofibres for Medical Coatings: Techniques and Applications
Royal Society of Chemistry eBooks,
Год журнала:
2024,
Номер
unknown, С. 214 - 250
Опубликована: Ноя. 15, 2024
The
development
of
biocompatible
nanofibres
through
electrospinning
is
a
promising
method
for
engineers
in
the
biomedical
field.
existing
coating
technologies
medical
field
have
various
limitations,
and
more
investigations
are
needed
to
improve
their
biocompatibility,
controlled
release
properties,
mechanical
strength.
Designing
new
materials
that
can
interact
efficiently
with
biological
systems
offer
numerous
functional
advantages
major
challenge
device
manufacturing
tissue
engineering.
This
chapter
reviews
approaches
used
create
nanofibres,
including
design,
fabrication
functionalization.
applications
these
coatings
also
reviewed.
Furthermore,
we
discuss
methods,
used,
key
parameters
impact
fibre
morphology
physiochemical
properties.
Moreover,
incorporation
bioactive
elements
drugs
into
therapeutic
explored.
biologically
friendly
be
an
effective
approach
improving
coatings.
Such
enhance
properties
such
as
drug
delivery,
regeneration,
implant
integration,
offering
enormous
potential
patient
welfare.
Future
research
areas
include
investigating
use
advanced
procedures
enhanced
control
over
nanofibre
composition
design
fabrication.
Язык: Английский