Biomacromolecules,
Год журнала:
2024,
Номер
25(11), С. 7529 - 7542
Опубликована: Окт. 28, 2024
Moisture
loss,
infection,
and
severe
inflammatory
reactions
are
the
primary
factors
affecting
burn
wound
healing
leading
to
scar
formation.
Herein,
we
developed
a
quercetin-loaded
polysaccharide-based
injectable
hydrogel
(named
PECE).
The
PECE
consists
of
oxidized
sodium
alginate
(OAlg)
coupled
with
chitosan
(CS)
via
Schiff
bases
electrostatic
interactions,
while
Que
is
incorporated
hydrogen
bonding.
Benefiting
from
hydroxyl
carboxyl
groups,
features
distinguished
moisturizing
ability.
Additionally,
sustained
release
imparts
remarkable
antibacterial
activity
against
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
Abstract
The
hydrogel
adhesives
with
strong
tissue
adhesion
and
biological
characteristics
adhm202404447are
urgently
needed
for
injury
sealing
repair.
However,
the
negative
correlation
between
mechanical
strength
poses
a
challenge
their
practical
application.
Herein,
bio‐inspired
cohesive
enhancement
strategy
is
developed
to
prepare
adhesive
simultaneously
enhanced
adhesion.
double
cross‐linked
network
achieved
through
cooperation
polyacrylic
acid
grafted
N‐hydroxy
succinimide
crosslinked
by
tannic
cohesion‐enhanced
ion
crosslinking
of
sodium
alginate
Ca
2+
.
Such
unique
structure
endows
resultant
excellent
strength.
capable
various
organs
in
vitro,
exhibits
satisfactory
on‐demand
removability,
antibacterial,
antioxidant
properties.
As
proof
concept,
not
only
effectively
halts
non‐compressible
hemorrhages
beating
heart
femoral
artery
models
rats,
but
also
accelerates
healing
infected
wound
inhibiting
bacteria
reducing
inflammation.
Overall,
this
advanced
promising
as
an
emergency
rescue
that
enables
robust
closure,
timely
controlling
bleeding,
promoting
damaged
healing.
Polymers,
Год журнала:
2024,
Номер
16(13), С. 1937 - 1937
Опубликована: Июль 6, 2024
Over
millions
of
years
evolution,
nature
has
developed
a
myriad
unique
features
that
have
inspired
the
design
adhesives
for
wound
healing.
Bionic
hydrogel
adhesives,
capable
adapting
to
dynamic
movements
tissues,
possess
superior
biocompatibility
and
effectively
promote
healing
both
external
internal
wounds.
This
paper
provides
systematic
review
principles
these
focusing
on
treatment
skin
wounds,
explores
feasibility
incorporating
nature-inspired
properties
into
their
design.
The
adhesion
mechanisms
bionic
are
analyzed
from
chemical
physical
perspectives.
Materials
natural
synthetic
polymers
commonly
used
as
detailed
regarding
degradability.
multifunctional
elements
trauma
treatment,
such
self-healing,
drug
release,
responsive
design,
optimization
mechanical
properties,
further
explored.
aim
is
overcome
limitations
conventional
treatments
offer
safer,
more
effective
solution
application
dressings.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
17(2), С. 2940 - 2951
Опубликована: Янв. 7, 2025
This
study
introduced
a
hydrogel
dressing,
termed
SODex-gel,
which
was
constructed
by
establishing
Schiff
base
and
hydrogen
bonds
with
the
precursors
of
oxidized
dextran
(ODex)
succinic
dihydrazide
(SD)-modified
sodium
alginate
(SD-mod-SA).
Through
comprehensive
in
vitro
vivo
studies,
adhesive
properties,
self-healing
capabilities,
hemostatic
potential,
wound
healing
efficacy
SODex-gel
dressing
were
meticulously
evaluated.
The
1H
NMR,
FTIR,
TGA
analyses
confirmed
fabrication
its
constituent
elements.
Scanning
electron
microscopy
(SEM)
imaging
showcased
uniform
pore
structures
dressing.
In
assessments
demonstrated
that
noncytotoxic
exhibits
strong
adhesion,
enabling
it
to
attach
various
surfaces.
Noteworthy
findings
from
studies
mouse
liver
incisions
tail
amputation
models
proved
ability
Moreover,
their
remarkable
wound-healing
capabilities
prominently
through
treatment
model
afflicted
burn
skin
injuries.
Evidence
neovascularization
effects
corroborated
upregulation
CD31
vascular
endothelial
growth
factor
(VEGF)
expression
treated
samples.
Collectively,
experimental
data
unequivocally
established
is
promising
therapeutic
approach
accelerate
recovery,
thereby
exhibiting
substantial
potential
for
clinical
applications
treating
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 28, 2025
Wound
healing
remains
a
global
challenge
for
clinical
and
experimental
research.
Hydrogels
prepared
from
natural
polysaccharides
show
great
potential
in
the
wound
process.
In
this
study,
novel
hydrogels
(G-GLP)
were
using
oxidized
Ganoderma
lucidum
(OGLPs)
carboxymethyl
chitosan
via
Schiff
base
reaction,
which
did
not
require
addition
of
any
chemical
cross-linking
agent.
The
showed
excellent
mechanical
properties
biocompatibility.
Moreover,
superior
hemostatic
performance
mouse
liver
trauma
tail
amputation
models.
Importantly,
G-GLP
improved
inflammation
by
promoting
polarization
macrophage
M2
subtype,
inhibiting
M1
subtype
reducing
intracellular
levels
reactive
oxygen
species.
vivo
experiments
demonstrated
that
accelerated
total
defect
model
blood
vessel
repair
collagen
deposition.
These
results
demonstrate
has
as
an
effective
dressing.
Biomaterials Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Plant-derived
cytoderm
ghost
(PCG)
drug
delivery
systems
leverage
bacterial
responsiveness
to
enable
controlled
release
of
drugs
for
treatment
related
diseases.
Molecules,
Год журнала:
2024,
Номер
29(18), С. 4360 - 4360
Опубликована: Сен. 13, 2024
Carboxymethyl
chitosan
(CMCS)
hydrogels
have
been
investigated
in
biomedical
research
because
of
their
versatile
properties
that
make
them
suitable
for
various
medical
applications.
Key
are
especially
valuable
use
include
biocompatibility,
tailored
solid-like
mechanical
characteristics,
biodegradability,
antibacterial
activity,
moisture
retention,
and
pH
stimuli-sensitive
swelling.
These
features
offer
advantages
such
as
enhanced
healing,
promotion
granulation
tissue
formation,
facilitation
neutrophil
migration.
As
a
result,
CMCS
favorable
materials
applications
biopharmaceuticals,
drug
delivery
systems,
wound
engineering,
more.
Understanding
the
interactions
between
biological
with
focus
on
influence
cellular
behavior,
is
crucial
leveraging
versatility.
Because
constantly
growing
interest
its
derivative
applications,
present
review
aims
to
provide
updated
insights
into
potential
based
recent
findings.
Additionally,
we
comprehensively
elucidated
mechanisms
underlying
actions
these
settings.
In
summary,
this
paper
recapitulates
data
gathered
from
current
literature,
offering
perspectives
further
development
utilization
carboxymethyl
contexts.
