Artificial intelligence‐assisted design, synthesis and analysis of smart biomaterials
BMEMat,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 25, 2025
Abstract
Smart
biomaterials
that
can
self‐adapt
or
respond
to
microenvironmental
factors
external
signals
hold
excellent
potential
for
a
variety
of
biomedical
applications,
from
biosensing,
drug
delivery,
and
cell
therapy
tissue
engineering.
The
complexity
smart
biomaterials,
including
the
rational
design
their
structure
composition,
accurate
analysis
prediction
properties,
automatic
scale‐up
synthesis
remains
critical
challenge
but
be
addressed
by
recent
rise
artificial
intelligence
(AI).
To
bridge
literature
gap,
current
mini‐review
will
introduce
background
why
marrying
AI
with
is
essential
how
biomaterial
scientists
integrate
machine
learning
(ML)
discovery,
design,
analysis,
biomaterials.
For
this
purpose,
basic
principles
ML
first
introduced
so
use
as
tool
research.
Next,
representative
examples
using
high
throughput
screen
establish
big
data
structure‐function
relationship
responding
both
chemical,
biological,
physical
signals.
Most
importantly,
applications
AI‐designed
AI‐discovered
overviewed,
focus
on
field
Lastly,
new
directions,
such
robot‐chemists‐assisted
fabrication
highlighted.
Taken
together,
engaging
most
updates
in
material
science,
we
expect
observe
continuous
growth
science
benefit
clinical
translation
treating
diseases.
Язык: Английский
Recyclable terthiophenes for synthesizing precision conjugated oligomers
Polymer Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Precision
oligothiophenes
were
synthesized
from
terthiophene
in
an
efficient
manner.
Interestingly,
the
unreacted
was
readily
recovered
and
reused
subsequent
synthesis.
Язык: Английский
Surface Engineering of Ti6Al4V: Impact of Rhenium–Carbon Coatings with Molybdenum Anchors on Biocompatibility and Corrosion Behavior
Metals,
Год журнала:
2024,
Номер
14(10), С. 1144 - 1144
Опубликована: Окт. 8, 2024
Titanium
alloys,
particularly
Ti6Al4V,
are
widely
used
in
biomedical
applications
due
to
their
excellent
mechanical
properties
and
inherent
biocompatibility.
However,
enhancing
surface
characteristics,
such
as
biocompatibility
corrosion
resistance,
remains
a
key
challenge
for
long-term
use
medical
implants.
In
this
study,
we
investigate
the
effects
of
rhenium–carbon
coatings
deposited
on
Ti6Al4V
substrates
via
magnetron
sputtering,
incorporating
molybdenum
anchoring
layer.
X-ray
diffraction
(XRD)
energy
dispersive
spectroscopy
(EDS)
analyses
confirmed
formation
rhenium
carbides,
elemental
rhenium,
oxides
within
coatings.
Despite
these
successful
depositions,
scanning
electron
microscopy
(SEM)
revealed
significant
delamination
poor
adhesion
substrates.
Corrosion
evaluated
through
potentiodynamic
polarization
tests,
showed
an
increase
current
densities
more
negative
potentials,
indicating
detrimental
effect
substrate’s
resistance.
Biocompatibility
assessments
using
PK15
cells
demonstrated
marked
decrease
cell
viability
metabolic
activity,
samples
with
higher
roughness.
These
findings
underscore
critical
need
optimization
preparation
deposition
processes
improve
both
Future
research
should
aim
refine
coating
technique
enhance
adhesion,
explore
mechanisms
cytotoxicity
related
roughness,
expand
studies
across
different
lines
biological
environments.
Язык: Английский