Designing Multivalent Aptamers: Recent Advancements in Diagnostic and Therapeutic Approaches for Cancer Treatment

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106614 - 106614

Опубликована: Янв. 1, 2025

Язык: Английский

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Large-capacity DNA vectors based on rolling circle amplification with multivalent aptamers delivery copper sulfide for the synergistic treatment of Cancer through chemo/Photothermal/Chemodynamic therapy in vitro

Journal of Inorganic Biochemistry, Год журнала: 2025, Номер 265, С. 112831 - 112831

Опубликована: Янв. 17, 2025

Язык: Английский

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“Calabash Vine” Nanoassembly for Chemotherapy and Photothermal Combination Therapy of Breast Cancer

Langmuir, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

DNA nanoassembly-loaded CFA@SD core-shell nanoparticles and doxorubicin (Dox) were constructed based on the rolling circle amplification reaction (RCA), which is called CFA@RD NAs. CFA NPs was prepared by coating a gold nanoshell surface of Fe3O4 modified with citrate. Then, single-stranded (SD, partial sequence complementary to RCA) further through gold-sulfur bond synthesize NPs. An RCA assembly (RA) integrating two different functional DNAs (S2.2 aptamer strand support strand) as basic skeleton. Based principle base pairing Dox/G-C autonomic binding, Dox loaded onto RA carrier construct CFA@RA-Dox nanoassembly (CFA@RD NAs). In vitro cell experiments showed that dual targeting active magnetic passive targeting) significantly enhanced uptake NAs MCF-7 cells reduced toxic side effects normal cells. The loading achieved aggregation between NPs, causing have better photothermal effect. addition, amount about 255 nmol/mol, under conditions simulating intracellular environment, could be quickly released within 30 min. high effective release caused it an efficient CT This study provides strategy for combined killing nanotechnology targeting, therapy (PTT), chemotherapy (CT), has obvious advantages over traditional single great potential in treatment breast cancer.

Язык: Английский

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Rolling circle amplification-Induced Self-Assembly of gold nanorods to form One-Dimensional arrays Equipped ‘Multi-Locator’ for fluorescence imaging and enhancement photothermal tumor therapy

Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127317 - 127317

Опубликована: Март 1, 2025

Язык: Английский

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