Crystal Growth & Design,
Год журнала:
2024,
Номер
24(6), С. 2580 - 2591
Опубликована: Март 7, 2024
The
solid–liquid
phase
equilibrium
data
of
theophylline
and
isonicotinamide
in
selected
solvents
(isopropanol,
N,N-dimethylformamide,
n-pentanol)
were
determined
by
using
the
static
method
at
298.15
308.15
K
under
101.325
kPa.
ternary
diagram
was
plotted,
it
concluded
that
is
an
asymmetric
diagram.
mechanism
solid-phase
formation
cocrystals
during
determination
discussed.
Excessive
amounts
THE
INA
cause
system
to
become
supersaturated.
As
cocrystal
forms,
solubility
decreases.
When
on
solvation
curve
cocrystal,
activity
coefficients
drop
critical
values
stops.
Based
analysis
diagrams
for
cocrystals,
two
routes
obtaining
THE-INA
from
solution
have
been
proposed
validated.
For
route
1,
concentrations
are
adjusted
appropriate
concentrations,
then,
solvent
evaporation
performed
achieve
crystallization.
2,
amount
added
a
highly
concentrated
solution.
variation
main
constitutive
forces
explored
molecular
simulation
simulations.
types
interaction
their
energies
systems
identified.
In
addition,
melting
temperature
enthalpy
fusion
obtained
be
462.26
(onset)
131.69
J/g,
respectively.
Chemical Reviews,
Год журнала:
2022,
Номер
122(13), С. 11514 - 11603
Опубликована: Июнь 1, 2022
The
subject
of
crystal
engineering
started
in
the
1970s
with
study
topochemical
reactions
solid
state.
A
broad
chemical
definition
was
published
1989,
and
supramolecular
synthon
concept
proposed
1995
followed
by
heterosynthons
their
potential
applications
for
design
pharmaceutical
cocrystals
2004.
This
review
traces
development
synthons
as
robust
recurring
hydrogen
bond
patterns
construction
architectures,
notably,
beginning
early
2000s
to
present
time.
ability
a
cocrystal
between
an
active
ingredient
(API)
pharmaceutically
acceptable
coformer
systematically
tune
physicochemical
properties
drug
(i.e.,
solubility,
permeability,
hydration,
color,
compaction,
tableting,
bioavailability)
without
changing
its
molecular
structure
is
hallmark
platform,
bridge
discovery
development.
With
via
prototype
case
studies
improve
solubility
place
(2000–2015),
period
2015
time
has
witnessed
launch
several
salt–cocrystal
drugs
improved
efficacy
high
bioavailability.
on
design,
synthesis,
afford
products
substances
will
interest
researchers
engineering,
chemistry,
medicinal
process
development,
materials
sciences.
scale-up
salts
using
continuous
manufacturing
technologies
provides
high-value
pharmaceuticals
economic
environmental
benefits.
CrystEngComm,
Год журнала:
2021,
Номер
23(40), С. 7005 - 7038
Опубликована: Янв. 1, 2021
This
highlight
presents
an
overview
of
pharmaceutical
cocrystal
production
and
its
potential
in
reviving
problematic
properties
drugs
different
dosage
forms.
The
challenges
future
outlook
translational
development
are
discussed.
Crystal Growth & Design,
Год журнала:
2023,
Номер
23(6), С. 4680 - 4700
Опубликована: Май 12, 2023
Cocrystal
engineering
is
gaining
interest
across
various
disciplines
since
it
can
effectively
tune
the
properties
of
solid
substances
via
noncovalent
synthesis
by
introducing
new
components
into
lattice.
Mechanochemistry
without
a
doubt
most
valuable
tool
for
research
cocrystals,
which
combines
pursuit
efficient
and
sustainable
process
pathways
with
exploration
supramolecular
synthons
that
cannot
be
discovered
using
solution
methods.
In
this
review,
concerning
significance
mechanochemical
we
begin
outlining
strategies
preparation
cocrystals.
We
then
elaborate
on
theoretical
mechanisms
mechanochemically
induced
formation
cocrystals
their
polymorphs.
On
foundation,
several
cross-fields
in
mechanochemistry
enhances
application
value
cocrystal
are
shown
to
overcome
existing
limitations,
difficult
or
impossible
access
conventional
More
importantly,
demonstrate
introduction
methods,
such
as
cultivating
single
crystals
from
melt
microdroplets,
techniques,
microelectron
diffraction
(Micro-ED),
has
harmoniously
united
fields
mechanochemistry.
Finally,
brief
conclusion
outlook
presented,
including
current
challenges
future
opportunities
cooperation
engineering.
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(28), С. 10500 - 10524
Опубликована: Июль 7, 2023
Achieving
rapid
global
agricultural
development
while
maintaining
ecological
harmony
is
a
major
challenge
of
the
new
millennium.
Meeting
this
requires
efficient
and
environmentally
friendly
agrochemicals,
including
pesticides
fertilizers.
Molecular
assembly,
as
promising
strategy,
has
garnered
significant
attention
in
recent
years
for
advanced
solid-state
forms
agrochemicals.
In
review,
we
present
potential
advancements
forms,
such
polymorphs,
cocrystals/salts,
solvates,
inclusion
compounds,
amorphous
state,
production
high-efficiency
low-polluting
agrochemical
products.
We
provide
an
overview
concepts
preparation
methods
these
followed
by
exploration
their
applications
sustainable
agriculture.
Specifically,
highlight
value
enhancing
pesticide
solubility,
enabling
controlled
release
chemical
fertilizers,
reducing
off-target
risks.
Lastly,
discuss
challenges
prospects
associated
with
utilization
advancement
Journal of drug targeting,
Год журнала:
2024,
Номер
32(2), С. 115 - 127
Опубликована: Янв. 2, 2024
Pharmaceutical
cocrystals,
owing
to
their
manifold
applications,
are
acting
as
bridge
between
drug
discovery
and
pharmaceutical
product
development.
The
ability
scale
up
cocrystals
through
continuous
manufacturing
approaches
offers
superior
economic
products.
Moreover,
can
be
an
aid
for
the
nanoparticulate
systems
solve
issues
related
scale-up
cost.
Cocrystals
grabbed
attention
of
academic
researchers
scientist
due
potential
target
various
diseases
like
cancer.
present
review
is
mainly
focussed
on
diverse
comprehensive
applications
in
delivery
including
solubility
dissolution
enhancement,
improvement
bioavailability
drug,
mechanical
flow
properties
active
ingredients,
controlled/sustained
release
colour
tuning
API.
Besides,
phytochemical
based
multi-drug
tumour
therapy
have
been
discussed
this
review.
Additionally,
recent
progress
pertinent
also
included,
which
may
provide
future
directions
cocrystals.
Pharmaceutics,
Год журнала:
2021,
Номер
13(12), С. 2160 - 2160
Опубликована: Дек. 15, 2021
Active
pharmaceutical
ingredients
(APIs)
extracted
and
isolated
from
traditional
Chinese
medicines
(TCMs)
are
of
interest
for
drug
development
due
to
their
wide
range
biological
activities.
However,
the
overwhelming
majority
APIs
in
TCMs
(T-APIs),
including
flavonoids,
terpenoids,
alkaloids
phenolic
acids,
limited
by
poor
physicochemical
biopharmaceutical
properties,
such
as
solubility,
dissolution
performance,
stability
tabletability
development.
Cocrystallization
these
T-APIs
with
coformers
offers
unique
advantages
modulate
properties
drugs
without
compromising
therapeutic
benefits
non-covalent
interactions.
This
review
provides
a
comprehensive
overview
current
challenges,
applications,
future
directions
T-API
cocrystals,
cocrystal
designs,
preparation
methods,
modifications
corresponding
mechanisms
properties.
Moreover,
variety
studies
presented
elucidate
relationship
between
crystal
structures
cocrystals
resulting
along
underlying
mechanism
changes.
It
is
believed
that
understanding
engineering
could
contribute
more
bioactive
natural
compounds
into
new
drugs.
Green Chemistry,
Год журнала:
2022,
Номер
24(20), С. 8088 - 8099
Опубликована: Янв. 1, 2022
Cocrystal
engineering
strategy
achieved
the
leaching
reduction
and
sustained
release
of
highly
water-soluble
herbicides
to
extend
their
efficacy
reduce
groundwater
contamination.
