Determination of the Asymmetric Ternary Phase Diagram and Preparation of Theophylline–Isonicotinamide Cocrystals DOI
Wenju Liu, Xiaolong Yang, Shaofeng Wang

и другие.

Crystal Growth & Design, Год журнала: 2024, Номер 24(6), С. 2580 - 2591

Опубликована: Март 7, 2024

The solid–liquid phase equilibrium data of theophylline and isonicotinamide in selected solvents (isopropanol, N,N-dimethylformamide, n-pentanol) were determined by using the static method at 298.15 308.15 K under 101.325 kPa. ternary diagram was plotted, it concluded that is an asymmetric diagram. mechanism solid-phase formation cocrystals during determination discussed. Excessive amounts THE INA cause system to become supersaturated. As cocrystal forms, solubility decreases. When on solvation curve cocrystal, activity coefficients drop critical values stops. Based analysis diagrams for cocrystals, two routes obtaining THE-INA from solution have been proposed validated. For route 1, concentrations are adjusted appropriate concentrations, then, solvent evaporation performed achieve crystallization. 2, amount added a highly concentrated solution. variation main constitutive forces explored molecular simulation simulations. types interaction their energies systems identified. In addition, melting temperature enthalpy fusion obtained be 462.26 (onset) 131.69 J/g, respectively.

Язык: Английский

Crystal Engineering of Pharmaceutical Cocrystals in the Discovery and Development of Improved Drugs DOI
Geetha Bolla, Bipul Sarma, Ashwini Nangia

и другие.

Chemical Reviews, Год журнала: 2022, Номер 122(13), С. 11514 - 11603

Опубликована: Июнь 1, 2022

The subject of crystal engineering started in the 1970s with study topochemical reactions solid state. A broad chemical definition was published 1989, and supramolecular synthon concept proposed 1995 followed by heterosynthons their potential applications for design pharmaceutical cocrystals 2004. This review traces development synthons as robust recurring hydrogen bond patterns construction architectures, notably, beginning early 2000s to present time. ability a cocrystal between an active ingredient (API) pharmaceutically acceptable coformer systematically tune physicochemical properties drug (i.e., solubility, permeability, hydration, color, compaction, tableting, bioavailability) without changing its molecular structure is hallmark platform, bridge discovery development. With via prototype case studies improve solubility place (2000–2015), period 2015 time has witnessed launch several salt–cocrystal drugs improved efficacy high bioavailability. on design, synthesis, afford products substances will interest researchers engineering, chemistry, medicinal process development, materials sciences. scale-up salts using continuous manufacturing technologies provides high-value pharmaceuticals economic environmental benefits.

Язык: Английский

Процитировано

352

Cocrystal engineering of pharmaceutical solids: therapeutic potential and challenges DOI

Si Nga Wong,

Yu Chee Sonia Chen,

Bianfei Xuan

и другие.

CrystEngComm, Год журнала: 2021, Номер 23(40), С. 7005 - 7038

Опубликована: Янв. 1, 2021

This highlight presents an overview of pharmaceutical cocrystal production and its potential in reviving problematic properties drugs different dosage forms. The challenges future outlook translational development are discussed.

Язык: Английский

Процитировано

79

Mechanochemical Synthesis of Cocrystal: From Mechanism to Application DOI
Yuntian Xiao,

Chuanhua Wu,

Xingchen Hu

и другие.

Crystal Growth & Design, Год журнала: 2023, Номер 23(6), С. 4680 - 4700

Опубликована: Май 12, 2023

Cocrystal engineering is gaining interest across various disciplines since it can effectively tune the properties of solid substances via noncovalent synthesis by introducing new components into lattice. Mechanochemistry without a doubt most valuable tool for research cocrystals, which combines pursuit efficient and sustainable process pathways with exploration supramolecular synthons that cannot be discovered using solution methods. In this review, concerning significance mechanochemical we begin outlining strategies preparation cocrystals. We then elaborate on theoretical mechanisms mechanochemically induced formation cocrystals their polymorphs. On foundation, several cross-fields in mechanochemistry enhances application value cocrystal are shown to overcome existing limitations, difficult or impossible access conventional More importantly, demonstrate introduction methods, such as cultivating single crystals from melt microdroplets, techniques, microelectron diffraction (Micro-ED), has harmoniously united fields mechanochemistry. Finally, brief conclusion outlook presented, including current challenges future opportunities cooperation engineering.

Язык: Английский

Процитировано

35

Pursuing Green and Efficient Agriculture from Molecular Assembly: A Review of Solid-State Forms on Agrochemicals DOI
Yuntian Xiao,

Chuanhua Wu,

Pingping Cui

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(28), С. 10500 - 10524

Опубликована: Июль 7, 2023

Achieving rapid global agricultural development while maintaining ecological harmony is a major challenge of the new millennium. Meeting this requires efficient and environmentally friendly agrochemicals, including pesticides fertilizers. Molecular assembly, as promising strategy, has garnered significant attention in recent years for advanced solid-state forms agrochemicals. In review, we present potential advancements forms, such polymorphs, cocrystals/salts, solvates, inclusion compounds, amorphous state, production high-efficiency low-polluting agrochemical products. We provide an overview concepts preparation methods these followed by exploration their applications sustainable agriculture. Specifically, highlight value enhancing pesticide solubility, enabling controlled release chemical fertilizers, reducing off-target risks. Lastly, discuss challenges prospects associated with utilization advancement

Язык: Английский

Процитировано

22

Cocrystallization of 5-fluorouracil with gallic acid: A novel 5-fluorouracil cocrystal displaying synergistic anti-tumor activity both in oral and intraperitoneal injection administration DOI
Han Hao, Yao Zhang, Xiaoxiao Hu

и другие.

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2023, Номер 187, С. 12 - 23

Опубликована: Апрель 7, 2023

Язык: Английский

Процитировано

20

Pharmaceutical cocrystals: a rising star in drug delivery applications DOI

Prabhakar Panzade,

Anita Wagh,

Pratiksha Harale

и другие.

Journal of drug targeting, Год журнала: 2024, Номер 32(2), С. 115 - 127

Опубликована: Янв. 2, 2024

Pharmaceutical cocrystals, owing to their manifold applications, are acting as bridge between drug discovery and pharmaceutical product development. The ability scale up cocrystals through continuous manufacturing approaches offers superior economic products. Moreover, can be an aid for the nanoparticulate systems solve issues related scale-up cost. Cocrystals grabbed attention of academic researchers scientist due potential target various diseases like cancer. present review is mainly focussed on diverse comprehensive applications in delivery including solubility dissolution enhancement, improvement bioavailability drug, mechanical flow properties active ingredients, controlled/sustained release colour tuning API. Besides, phytochemical based multi-drug tumour therapy have been discussed this review. Additionally, recent progress pertinent also included, which may provide future directions cocrystals.

Язык: Английский

Процитировано

9

Improving the Physicochemical and Biopharmaceutical Properties of Active Pharmaceutical Ingredients Derived from Traditional Chinese Medicine through Cocrystal Engineering DOI Creative Commons
Danyingzi Guan, Bianfei Xuan,

Chengguang Wang

и другие.

Pharmaceutics, Год журнала: 2021, Номер 13(12), С. 2160 - 2160

Опубликована: Дек. 15, 2021

Active pharmaceutical ingredients (APIs) extracted and isolated from traditional Chinese medicines (TCMs) are of interest for drug development due to their wide range biological activities. However, the overwhelming majority APIs in TCMs (T-APIs), including flavonoids, terpenoids, alkaloids phenolic acids, limited by poor physicochemical biopharmaceutical properties, such as solubility, dissolution performance, stability tabletability development. Cocrystallization these T-APIs with coformers offers unique advantages modulate properties drugs without compromising therapeutic benefits non-covalent interactions. This review provides a comprehensive overview current challenges, applications, future directions T-API cocrystals, cocrystal designs, preparation methods, modifications corresponding mechanisms properties. Moreover, variety studies presented elucidate relationship between crystal structures cocrystals resulting along underlying mechanism changes. It is believed that understanding engineering could contribute more bioactive natural compounds into new drugs.

Язык: Английский

Процитировано

35

Cocrystal engineering strategy for sustained release and leaching reduction of herbicides: a case study of metamitron DOI
Yuntian Xiao,

Chuanhua Wu,

Ling Zhou

и другие.

Green Chemistry, Год журнала: 2022, Номер 24(20), С. 8088 - 8099

Опубликована: Янв. 1, 2022

Cocrystal engineering strategy achieved the leaching reduction and sustained release of highly water-soluble herbicides to extend their efficacy reduce groundwater contamination.

Язык: Английский

Процитировано

26

Enhancing adsorption capacity and herbicidal efficacy of 2,4-D through supramolecular self-assembly: Insights from cocrystal engineering to solution chemistry DOI
Yuntian Xiao,

Chuanhua Wu,

Pingping Cui

и другие.

Chemical Engineering Journal, Год журнала: 2023, Номер 469, С. 143757 - 143757

Опубликована: Июнь 3, 2023

Язык: Английский

Процитировано

17

Green and efficient delivery of pesticides throughout their life cycle via cooperative solid and solution self-assembly DOI
Yuntian Xiao,

Chuanhua Wu,

Shanshan Feng

и другие.

Chemical Engineering Journal, Год журнала: 2023, Номер 475, С. 146037 - 146037

Опубликована: Сен. 13, 2023

Язык: Английский

Процитировано

14