The
categorization
of
energetic
crystals
is
beneficial
to
understand
the
intrinsic
structure
materials;
in
turn,
basis
for
categorizing
crystals.
This
chapter
introduces
category
crystals,
which
depends
on
characteristics
primary
constituent
parts
and
interactions
among
them.
These
structures
are
also
substructures
crystal
packing,
as
well
materials.
Thus,
correctly
helpful
properties
materials
use
them
rationally.
Pharmaceutics,
Год журнала:
2023,
Номер
15(1), С. 189 - 189
Опубликована: Янв. 5, 2023
Stability
is
an
essential
quality
attribute
of
any
pharmaceutical
formulation.
Poor
stability
can
change
the
color
and
physical
appearance
a
drug,
directly
impacting
patient's
perception.
Unstable
drug
products
may
also
face
loss
active
ingredients
(APIs)
degradation,
making
medicine
ineffective
toxic.
Moisture
content
known
to
be
leading
cause
degradation
nearly
50%
medicinal
products,
impurities
in
solid
dose
formulations.
The
polarity
atoms
API
surface
chemistry
particles
majorly
influence
affinity
towards
water
molecules.
induces
chemical
reactions,
including
free
that
has
been
identified
as
important
factor
determining
product
stability.
Among
various
approaches,
crystal
engineering
specifically
co-crystals,
have
proven
ability
increase
moisture-sensitive
APIs.
Other
such
changing
salt
form,
lead
solubility
issues,
thus
co-crystal
approach
more
suited
enhancing
hygroscopic
There
are
many
reported
studies
where
co-crystals
exhibited
reduced
hygroscopicity
compared
pure
API,
thereby
improving
product's
In
this
review,
authors
focus
on
recent
updates
trends
these
related
compounds,
discuss
reasons
behind
enhanced
stability,
briefly
screening
co-formers
for
drugs.
Crystal Growth & Design,
Год журнала:
2024,
Номер
24(7), С. 2734 - 2744
Опубликована: Март 19, 2024
In
general,
a
planar
molecule
with
identical
substituents
surrounding
its
skeleton
can
hardly
be
layer-stacked
in
crystal
under
common
conditions.
This
is
because
these
carry
the
same
charge,
and
their
close
arrangement
leads
to
intermolecular
electrostatic
repulsion.
Exceptionally,
2,4,6-triazido-1,3,5-triazine
(TATA)
2,5,8-triazido-s-heptazine
(TASHA)
are
such
molecules
each
three
azido
groups
(−N3)
around
but
still
stacked
pattern
of
layer.
paper
discloses
underlying
mechanism
for
exception.
It
found
that
molecular
edge
either
TATA
or
TASHA
not
always
covered
by
negative
potentials
(ESPs),
different
from
knowledge.
That
is,
TATA,
middle
N
atoms
−N3
positively
charged
produce
positive
ESP
parts,
remaining
reversely
present
ones;
thereby,
regions
alternately
appear
on
edge,
satisfying
necessary
requirement
layered
stacking.
Thus,
seeming
exception
exceptional.
understanding
verified
fit
other
like
TASHA.
Meanwhile,
it
alerts
us
carefully
consider
individual
both
when
they
exposed
as
outmost
parts
address
interaction
related
issues,
instead
substituent
whole.
Energetic Materials Frontiers,
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 1, 2024
Packing
density
is
a
basic
property
of
substances
and
acts
as
one
important
decisive
factors
service
performances.
This
work
focuses
upon
the
determining
packing
at
premise
CHON-containing
isomers
with
same
chemical
composition.
It
found
that,
for
group
isomers,
molecular
densities
vary
much
less
than
coefficients
densities,
regardless
significant
difference
structure
therein.
Thus,
coefficient
governs
density,
strategy
based
on
data
analysis
elevating
it
proposed,
such
introduction
strong
dense
hydrogen
bonds
formation
internal
salt.
Additionally,
C=O
beneficial
increasing
while
reducing
energy
release,
thus
can
hardly
be
considered
in
energetics.
Hopefully,
this
will
deepen
understanding
offer
new
avenue
designing
high
compounds.
Future Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
11(1)
Опубликована: Июнь 5, 2025
Abstract
Background
Bedaquiline
fumarate
(BDQ)
is
an
anti-tubercular
Biopharmaceutics
Classification
System
(BCS
class-II)
drug
&
it
has
very
less
solubility.
Therefore,
effort
been
made
to
prepare
the
bedaquiline
co-crystal
improve
its
physicochemical
and
pharmaceutical
characteristics.
Results
Using
solvent
evaporation
method,
co-former
ascorbic
acid
(AA)
were
co-crystallized.
A
series
of
analytical
techniques,
i.e.,
X-ray
diffraction
(XRD),
Fourier
transformation
infrared
spectroscopy
(FTIR),
differential
scanning
calorimetry
(DSC),
electron
microscopy
(SEM),
UV
spectroscopy,
etc.,
used
for
analysis
predict
formation
by
molecular
docking.
Micromeritic
study
tablet
formulation
done
(1:2)
batch.
permeability
was
conducted
on
chicken
ileum.
Conclusion
Active
ingredients
can
co-crystallize
with
other
small
molecules
or
co-formers
create
new
solid
dosage
forms
that
have
better
characteristics
than
pure
drugs.
22
screened
drug,
selected
as
a
because
binding
energy
−
1.2
kcal/mol,
two
hydrogen
bonds
are
formed,
becomes
readily
soluble
in
water.
This
indicated
increase
dissolution
profile
co-crystallization
approach.
Physical Chemistry Chemical Physics,
Год журнала:
2023,
Номер
25(15), С. 10384 - 10391
Опубликована: Янв. 1, 2023
The
present
work
concerns
a
basic
issue
in
molecular
science,
i.e.,
constructing
high
energy
isomer
with
given
composition.
Three
compositions
of
CH3NO2,
CH4N2O2,
and
CH3NO3
are
adopted
to
construct
various
isomers
the
internal
calculated
compared
ascertain
its
dependence
on
linking
order
atoms.
Thereby,
simple
rule
for
CHNO
is
summarized.
separation
reducing
C/H
atoms
oxidizing
O
by
N
as
well
direct
linkage
C-C,
C-H,
O-O,
benefits
energy;
other
hand,
O-O
leads
low
stability,
thus
double
atom
necessary
build
stable
energetic
molecule.
C-O
O-H
significantly
weakens
or
diminishes
activity
related
atoms,
can
be
called
died
This
expected
promote
screening
molecules
fields
fuels
materials.
Crystal Growth & Design,
Год журнала:
2024,
Номер
24(10), С. 4101 - 4113
Опубликована: Апрель 24, 2024
Organic
azides
possess
the
potential
for
green
primary
explosives,
gas
generators,
and
propellants.
This
work
focuses
on
crystal
packing
of
34
planar
organic
presents
an
understanding
their
properties
performances.
As
functional
group
azides,
–N3
is
wholly
weakly
charged,
individually,
outer,
middle,
inner
N
atoms
thereof
are
negatively,
rather
strongly
positively,
negatively
respectively.
weak
polarity
leads
to
intermolecular
interactions,
stemming
from
generally
lower
coefficients
densities
azide
crystals,
compared
with
some
typical
hydrogen
bond
(HB)-containing
nitro
compounds.
mostly
lonely
in
packing,
as
its
outer
atom
seldom
observed
HB
acceptor,
acts
intramolecular
acceptor
only
one
case
out
a
total
16.
Introducing
strong
acceptor/donor
groups
facilitates
enhancement
interaction
molecular/crystal
stability.
Ascribed
extremely
low
molecular
stability,
no
evident
dependence
impact
sensitivity
stacking
mode
found
whole
azides.
The
top
three
lowest
all
contain
dense
or
moderately
HBs,
implying
that
introduction
could
be
strategy
enhancing
safety