Syntheses, Crystal Structure, Hirshfeld Surface Analyses of Cocrystals and Salt of a Flexible Imidazole Tethered Naphthalenediimide with Some Organic Acids
Journal of Structural Chemistry,
Год журнала:
2025,
Номер
66(1), С. 30 - 45
Опубликована: Янв. 1, 2025
Язык: Английский
The pH-Dependent Microspecies Dissociations in the Trade-Off of Solubility and Permeability of Vitamin B2 Eutectic Solids
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
22(4), С. 2246 - 2258
Опубликована: Март 5, 2025
The
microspecies-specific
physicochemical
properties
of
eutectic
solids
sparingly
water-soluble
micronutrient,
Vitamin
B2
(Riboflavin),
with
a
few
representative
BCS
drugs,
viz.,
Theophylline,
Theobromine,
Mesalamine,
and
Barbituric
acid
are
established.
interplay
solubility
drug
permeation
behavior
is
experimentally
determined
for
the
solids,
corroborated
concomitant
relative
concentrations
pH-dependent
microspecies
Riboflavin
drugs.
Partner
candidates
selected
from
different
quadrants
classification
to
apprehend
influence
their
on
overall
efficacy
solids.
coexistence
inseparable
ionic,
neutral,
and/or
zwitterionic
spotted,
pH-reliant
isomer-specific
inflection
pharmacokinetic
in
such
multicomponent
solid
formulations
demonstrated.
Язык: Английский
Crystal Engineering Strategies for Optimizing Skin Permeation
Crystal Growth & Design,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Язык: Английский
Exploring Salts of Memantine with Inorganic Anions: From Polymorphism and Solid-State Transitions to Potential for Drug Formulations
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
21(9), С. 4700 - 4707
Опубликована: Авг. 7, 2024
This
study
examines
pharmaceutically
acceptable
inorganic
salts
of
memantine,
specifically
focusing
on
hydrogen
sulfate,
and
dihydrogen
phosphate
salts,
with
the
aim
finding
alternatives
to
commonly
used
chloride
salt
in
treatment
Alzheimer's
disease.
Through
comprehensive
solid-state
characterization,
including
powder
X-ray
diffraction,
thermal
analysis,
solubility
testing,
we
unveil
complex
polymorphic
behaviors,
reversible
transitions,
significant
differences
stability
among
salts.
Notably,
sulfate
emerges
as
a
promising
candidate
for
drug
formulations,
offering
improved
solubility,
nonhygroscopic
nature,
favorable
morphological
characteristics
compared
existing
salt.
work
establishes
foundation
further
investigation
into
memantine
potential
therapeutics
efficacy.
Язык: Английский