Balancing the Heterocycles···Pyromellitic Dianhydride Interactions to Achieve Tunable Emission in Charge-Transfer Cocrystals
Crystal Growth & Design,
Год журнала:
2025,
Номер
25(5), С. 1653 - 1666
Опубликована: Фев. 24, 2025
Cocrystal
engineering
focuses
on
adjustable
noncovalent
interactions
(NCIs)
and
packing
motifs
through
different
functional
molecular
blocks
to
modulate
physicochemical
properties.
NCIs
are
vital
driving
forces
in
the
construction
of
organic
cocrystal
materials,
such
as
π–π
interactions,
arene–perfluoroarene
hydrogen
bonds,
halogen
bonds.
Herein,
pyromellitic
dianhydride
(PMDA)
serves
electron
acceptor,
three
heterocycle–acene-fused
electron-rich
donors,
including
5H-benzo[4,5]thieno[3,2-c]carbazole
(BTCZ),
5H-benzofuro[3,2-c]carbazole
(BFCZ),
5,12-dihydroindolo[3,2-a]carbazole
(ICZ),
selected
react
with
PMDA
fabricate
cocrystals.
Single
crystals
BTCZ-PMDA,
BFCZ-PMDA,
ICZ-PMDA
were
grown
via
slow
cooling
solvent
evaporation,
their
crystal
structures,
quantified
NCIs,
photoluminescent
properties
investigated.
The
results
indicate
that
two
types
along
stacking
direction
show
imbalanced
interaction
energies
for
BTCZ-PMDA
while
well
balanced
within
ICZ-PMDA.
Moreover,
red
shift
peak
from
1.83
eV
(BTCZ-PMDA)
1.53
(ICZ-PMDA)
can
be
ascribed
heterocycles···PMDA
overall
enhancement
bond
(N–H···O
C–H···O).
Therefore,
balancing
solid-state
offer
a
promising
strategy
fluorescence
charge-transfer
Язык: Английский
High-Throughput Encapsulated Nanodroplet Screening for Accelerated Co-Crystal Discovery
Chemical Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
high-throughput
nanoscale
co-crystallisation
approach
is
presented,
that
combines
automation
and
small
scale
to
enable
the
exploration
of
conditions,
resulting
in
30
new
binary,
ternary
quaternary
co-crystals.
Язык: Английский
Novel Drug–Drug Cocrystalline Forms of Carbamazepine with Sulfacetamide: Preparation, Characterization, and In Vitro/In Vivo Performance Evaluation
Pharmaceutics,
Год журнала:
2025,
Номер
17(5), С. 678 - 678
Опубликована: Май 21, 2025
Objectives:
Drug–drug
cocrystallization
represents
a
promising
approach
for
the
development
of
novel
combination
drugs
with
improved
physicochemical
and
biopharmaceutical
properties.
The
aim
present
research
is
to
prepare
drug-drug
cocrystalline
forms
antiepileptic
drug
carbamazepine
(CBZ)
sulfacetamide
(SCTM).
Methods:
CBZ
cocrystal
methanol
solvate
hydrate
were
prepared
via
solvent
evaporation
technique
characterized
by
single
crystal
X-ray
diffraction,
differential
scanning
calorimetry
thermogravimetric
analysis.
Results:
Single-crystal
diffraction
thermal
analysis
revealed
that
multicomponent
solids
are
isostructural,
wherein
molecule
does
not
play
structure-forming
role.
To
optimize
synthesis
[CBZ+SCTM+H2O]
(1:1:0.7),
binary
ternary
phase
diagrams
constructed
in
acetonitrile
at
25
°C.
A
thorough
investigation
behavior
aqueous
solution
showed
pH
dissolution
medium
exerted
significant
effect
on
stability
solubility
(1:1:0.7).
According
diffusion
experiments
buffer
6.5,
an
enhanced
rate
flux
CBZ.
Pharmacokinetic
studies
rabbits
exhibited
comparable
bioavailability
parent
Conclusions:
Overall,
this
work
reports
preparation
hydrate,
which
can
be
considered
as
alternative
solid
form
oral
usage,
possessing
additive
pharmacological
effect.
Язык: Английский
Pharmaceutical Cocrystals for Drug Delivery
Burger's Medicinal Chemistry and Drug Discovery,
Год журнала:
2025,
Номер
unknown, С. 1 - 62
Опубликована: Май 26, 2025
Abstract
Pharmaceutical
cocrystals
offer
the
ability
to
tune
solubility,
permeability,
tableting,
and
bioavailability
of
a
solid,
oral
drug
formulation
without
changing
chemical
structure
molecule.
Crystal
engineering
pharmaceutical
salts
via
supramolecular
heterosynthons
with
acceptable
generally
recognized
as
safe
(GRAS)
coformers
provides
platform
technology
for
improving
efficacy
optimal
delivery.
With
almost
90%
drugs
in
Biopharmaceutics
Classification
System
(BCS)
class
II
IV
suffering
from
low‐solubility
and/or
low‐permeability
challenges,
have
provided
an
opportune
intervention
populating
pipeline
over
past
decade.
From
prototype
cocrystal
itraconazole‐succinic
acid
first
salt‐cocrystal
complex
Entresto
containing
valsartan‐sacubitril,
this
review
covers
origins
subject
early
2000s
peak
growth
curve
model
systems
between
2005
2015,
successful
lab‐to‐market
translation
witnessed
The
combined
application
machine
learning
neural
network
tools
is
bringing
speed
accuracy
research
exercise
designing
drug–coformer
therapeutic
properties.
This
article
snapshot
summary
latest
trends
leading
discovery,
development,
continuous
manufacturing.
Язык: Английский