Catalytic Efficacy of a 2D Chemically Robust MOF for the Synthesis of Bioactive Diindolylmethane (DIM)‐Based Drug Molecules DOI Open Access
Rupam Sahoo, Bikram Pramanik, Madhab C. Das

и другие.

Small, Год журнала: 2025, Номер 21(11)

Опубликована: Фев. 14, 2025

Abstract Synthesis of biologically and pharmaceutically important drugs via organic transformations in one pot under mild conditions with efficient catalysts is significant interest terms practical utility. Though metal‐organic frameworks (MOFs) prove their efficiencies various catalytic reactions, synthesis drug molecules employing MOF still its early stage, fact, restricted to only 1,4‐Dihydropyridines (1,4‐DHP) based synthesis. Although the Friedel–Crafts alkylation (FCA) reaction oldest reactions a impact on synthesis, surprisingly this triggered by catalyst largely unexplored. Herein, we report robust framework, MO F : IITKGP‐55 , synthesized solely aqueous medium which exhibits superior for one‐pot FCA well tolerance substrate scopes. Most importantly, reaction, three bioactive diindolylmethane (DIM) core are first time, was never realized any sort heterogeneous catalysts. Moreover, Arundine crystallized an in‐depth crystallographic analysis performed. The excellent framework robustness highlight potentiality developed unwrap new avenue molecule

Язык: Английский

Catalytic Efficacy of a 2D Chemically Robust MOF for the Synthesis of Bioactive Diindolylmethane (DIM)‐Based Drug Molecules DOI Open Access
Rupam Sahoo, Bikram Pramanik, Madhab C. Das

и другие.

Small, Год журнала: 2025, Номер 21(11)

Опубликована: Фев. 14, 2025

Abstract Synthesis of biologically and pharmaceutically important drugs via organic transformations in one pot under mild conditions with efficient catalysts is significant interest terms practical utility. Though metal‐organic frameworks (MOFs) prove their efficiencies various catalytic reactions, synthesis drug molecules employing MOF still its early stage, fact, restricted to only 1,4‐Dihydropyridines (1,4‐DHP) based synthesis. Although the Friedel–Crafts alkylation (FCA) reaction oldest reactions a impact on synthesis, surprisingly this triggered by catalyst largely unexplored. Herein, we report robust framework, MO F : IITKGP‐55 , synthesized solely aqueous medium which exhibits superior for one‐pot FCA well tolerance substrate scopes. Most importantly, reaction, three bioactive diindolylmethane (DIM) core are first time, was never realized any sort heterogeneous catalysts. Moreover, Arundine crystallized an in‐depth crystallographic analysis performed. The excellent framework robustness highlight potentiality developed unwrap new avenue molecule

Язык: Английский

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