Morphology and properties of CL-20/MTNP cocrystal prepared via facile spray drying DOI Creative Commons
Xueyan Zhao, Zongwei Yang, Shen Qiao

и другие.

FirePhysChem, Год журнала: 2022, Номер 3(2), С. 158 - 163

Опубликована: Окт. 9, 2022

Cocrystal of 2,4,6,8,10,12-hexaazaisowurtzitane/1-methyl-3,4,5-trinitropyrazole (CL-20/MTNP) in a 1:1 molar ratio is promising energetic material, since it combines the superior detonation performance CL-20 and good mechanical sensitivity MTNP. In order to promote its progress practical use, rapid, facile candidate large-scale manufacture method-spray drying was used prepare CL-20/MTNP cocrystal this study. The morphology, crystal structure thermodynamic behavior resulted CL-20/MTNP-SD cocrystal, raw materials prepared via solvent evaporation method (CL-20/MTNP-E) were systematically studied by scanning electron microscopy (SEM), X-ray diffraction spectroscopy (XRD) differential calorimetry (DSC), respectively. shows regular spherical shape with diameter narrowly distributed from 0.2 µm 2 µm. This morphology different rod-like CL-20/MTNP-E cocrystal. thermal similar totally materials. Additionally, initiation temperature activation energy for decomposition are slightly lower than short pulse slapper cocrystals have been investigated. spray endows ability being initiated short-duration impulse. And impact initiating threshold even commonly explosive 2,2′,4,4′,6,6′-hexanitrostilbene (HNS). result evokes prospective application as an impulse shockwave.

Язык: Английский

Metolazone co-crystals-loaded oral fast dissolving films: Design, optimization, and in vivo evaluation DOI

Mohamed S. Mohamed,

Ahmed A. El-Shenawy,

H. E. Ramadan

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 90, С. 105167 - 105167

Опубликована: Ноя. 15, 2023

Язык: Английский

Процитировано

5
Design and computational insight into two novel CL-20 analogues, BNMTNIW and BNIMTNIW: high performance energetic materials DOI
Sohan Lal, Haixiang Gao, Jean’ne M. Shreeve

и другие.

New Journal of Chemistry, Год журнала: 2022, Номер 46(35), С. 16693 - 16701

Опубликована: Янв. 1, 2022

Novel CL-20 analogues, BNMTNIW and BNIMTNIW, were investigated, found to exhibit high densities, positive heats of formation excellent propulsive detonation performance with better stability than CL-20.

Язык: Английский

Процитировано

7
Theoretical predict structure and property of the novel CL-20/2,4-DNI cocrystal by systematic search approach DOI Creative Commons
Haojie Li, Jianchao Liu, Li Yang

и другие.

Defence Technology, Год журнала: 2021, Номер 18(6), С. 907 - 917

Опубликована: Апрель 20, 2021

Cocrystallization integrates the merits of high energy and insensitivity between energetic molecules to obtain energetics with satisfying performance. However, how supramolecular synthons accurately rapidly for predicting structure property cocrystal remains a challenging problem. In this research, an efficient systematic search approach predict CL-20/2,4-DNI has been proposed that 2,4-DNI revolves around CL-20 stoichiometric ratio 1:1 in accordance specified rules (hydrogen bond length: 2.2–3.0 Å; radius: 6.5 number hydrogen bond: 1–3). Eight possible were obtained by combining quantum chemistry molecular mechanics. Crystal prediction indicated there are four structures cocrystal, namely P21/c, P212121, Pbca Pna21, is likely be P21/c corresponding cell parameters Z = 4, 8.28 Å, b 12.17 c 20.42 α 90°, β 96.94°, γ ρ 1.9353 g/cm3. To further study intermolecular interaction series theoretical analyses employed including energy, electrostatic potential (ESP), Density State (DOS), Hirshfeld surface analysis. The C–H⋯O bonds demonstrated as predominant driving forces formation. mechanical properties detonation implies shows better ductility excellent performances (9257 m/s, 39.27 GPa) can serve promising material. Cocrystal predicted was compared experimental one verify accuracy approach. There less than 8.8% error experiment results, indicating extremely reliability accuracy. new strategy identify effectively does have promote development design.

Язык: Английский

Процитировано

9
Co-crystallization of Hesperidin with different co-formers to enhance solubility, antioxidant and anti-inflammatory activities DOI

Mahmoud Elshaer,

Shaaban K. Osman,

Ahmed Mohammed

и другие.

Pharmaceutical Development and Technology, Год журнала: 2024, Номер 29(7), С. 691 - 702

Опубликована: Июль 24, 2024

Hesperidin (HSP) is a natural flavonoid glycoside with very low aqueous solubility and slow dissolution rate, limiting its effectiveness. This study aims to address these issues by creating co-crystals of hesperidin water-soluble small molecules (co-formers) such as L-arginine, glutathione, glycine, nicotinamide. Using the solvent drop grinding method, we prepared three different molar ratios co-formers (1:1, 1:3, 1:5) conducted in-vitro studies. The results demonstrated that exhibited significantly enhanced rates compared untreated hesperidin. Of particular note, HSP formula (HSP: L-arg displayed approximately 4.5 times higher than pure Further analysis using FTIR, powder x-ray diffraction patterns, DSC thermograms validated formation between L-arginine. Additionally, co-crystallization L-arginine improved in vitro anti-inflammatory antioxidant activities drug. highlights potential through enhance solubility, dissolution, biological poorly drugs. Furthermore, vivo studies are crucial validate promising results.

Язык: Английский

Процитировано

1
Morphology and properties of CL-20/MTNP cocrystal prepared via facile spray drying DOI Creative Commons
Xueyan Zhao, Zongwei Yang, Shen Qiao

и другие.

FirePhysChem, Год журнала: 2022, Номер 3(2), С. 158 - 163

Опубликована: Окт. 9, 2022

Cocrystal of 2,4,6,8,10,12-hexaazaisowurtzitane/1-methyl-3,4,5-trinitropyrazole (CL-20/MTNP) in a 1:1 molar ratio is promising energetic material, since it combines the superior detonation performance CL-20 and good mechanical sensitivity MTNP. In order to promote its progress practical use, rapid, facile candidate large-scale manufacture method-spray drying was used prepare CL-20/MTNP cocrystal this study. The morphology, crystal structure thermodynamic behavior resulted CL-20/MTNP-SD cocrystal, raw materials prepared via solvent evaporation method (CL-20/MTNP-E) were systematically studied by scanning electron microscopy (SEM), X-ray diffraction spectroscopy (XRD) differential calorimetry (DSC), respectively. shows regular spherical shape with diameter narrowly distributed from 0.2 µm 2 µm. This morphology different rod-like CL-20/MTNP-E cocrystal. thermal similar totally materials. Additionally, initiation temperature activation energy for decomposition are slightly lower than short pulse slapper cocrystals have been investigated. spray endows ability being initiated short-duration impulse. And impact initiating threshold even commonly explosive 2,2′,4,4′,6,6′-hexanitrostilbene (HNS). result evokes prospective application as an impulse shockwave.

Язык: Английский

Процитировано

5