Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing

Bioactive Materials, Год журнала: 2023, Номер 30, С. 129 - 141

Опубликована: Июль 28, 2023

In clinical applications, there is a lack of wound dressings that combine efficient resistance to drug-resistant bacteria with good self-healing properties. this study, series adhesive conductive antibacterial hydrogel based on oxidized sodium alginate-grafted dopamine/carboxymethyl chitosan/Fe3+ (OSD/CMC/Fe hydrogel)/polydopamine-encapsulated poly(thiophene-3-acetic acid) (OSD/CMC/Fe/PA hydrogel) were prepared for the repair infected wound. The Schiff base and Fe3+ coordination bonds structure are dynamic can be repaired automatically after network disrupted. Macroscopically, exhibits properties, allowing dressing adapt complex surfaces. OSD/CMC/Fe/PA showed conductivity photothermal properties under near-infrared (NIR) light irradiation. addition, hydrogels exhibit tunable rheological suitable mechanical antioxidant tissue adhesion hemostatic Furthermore, all improved healing in full-thickness defect skin test mice. size by OSD/CMC/Fe/PA3 + NIR was much smaller (12%) than control group treated Tegaderm™ film 14 days. conclusion, have high efficiency, conductivity, great biocompatibility, hemostasis making them promising candidates treatment wounds.

Язык: Английский

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Recent progress of antibacterial hydrogels in wound dressings

Materials Today Bio, Год журнала: 2023, Номер 19, С. 100582 - 100582

Опубликована: Фев. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Язык: Английский

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Photothermal antibacterial materials to promote wound healing

Journal of Controlled Release, Год журнала: 2023, Номер 363, С. 180 - 200

Опубликована: Сен. 27, 2023

Язык: Английский

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Bioinspired polydopamine hydrogels: Strategies and applications

Progress in Polymer Science, Год журнала: 2023, Номер 146, С. 101740 - 101740

Опубликована: Сен. 17, 2023

Язык: Английский

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Double Cross‐Linked Biomimetic Hyaluronic Acid‐Based Hydrogels with Thermo‐Stimulated Self‐Contraction and Tissue Adhesiveness for Accelerating Post‐Wound Closure and Wound Healing

Advanced Functional Materials, Год журнала: 2023, Номер 33(26)

Опубликована: Март 25, 2023

Abstract When skin trauma occurs, rapid achievement of the post‐wound closure is required to prevent microbial invasion, inhibit scar formation and promote wound healing. To develop a dressing for accelerating post‐wound‐closure healing, thermo‐responsive tissue‐adhesive hydrogel with interpenetrating polymer networks (IPN) fabricated based on N ‐dimethylbisacrylamide (NIPAM) glutaraldehyde (GTA) cross‐linked hyaluronic acid (HA). Results not only confirm thermo‐stimulated self‐contraction tissue adhesiveness HA‐based IPN (PNI‐HA), which effectively aids via mechanical stretch, but also verify hemocompatibility cytocompatibility PNI‐HA that tend accelerate In vivo, mouse model total defect demonstrates acting as sealant significantly achieves sutureless at early stage then promotes healing by reducing inflammatory cells infiltration, promoting angiogenesis well collagen deposition. These results indicate developed offers candidate serve

Язык: Английский

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Self‐Healing Hydrogel Bioelectronics

Advanced Materials, Год журнала: 2023, Номер 36(21)

Опубликована: Ноя. 22, 2023

Abstract Hydrogels have emerged as powerful building blocks to develop various soft bioelectronics because of their tissue‐like mechanical properties, superior bio‐compatibility, the ability conduct both electrons and ions, multiple stimuli‐responsiveness. However, hydrogels are vulnerable damage, which limits usage in developing durable hydrogel‐based bioelectronics. Self‐healing aim endow with property repairing specific functions after failure, thus improving durability, reliability, longevity. This review discusses recent advances self‐healing hydrogels, from mechanisms, material chemistry, strategies for properties improvement hydrogel materials, design, fabrication, applications bioelectronics, including wearable physical biochemical sensors, supercapacitors, flexible display devices, triboelectric nanogenerators (TENGs), implantable etc. Furthermore, persisting challenges hampering development prospects proposed. is expected expedite research

Язык: Английский

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Self-Healing Hydrogels: From Synthesis to Multiple Applications

ACS Materials Letters, Год журнала: 2023, Номер 5(7), С. 1787 - 1830

Опубликована: Май 26, 2023

Due to the good reliability and long-term stability, self-healing hydrogels have emerged as promising soft materials for tissue engineering, smart wearable sensors, bioelectronics, energy storage devices. The mechanism depends on reversible chemical or physical cross-linking interactions. Self-healing with fascinating features (including mechanical performances, biocompatibility, conductivity, antibacterial ability, responsiveness, etc.) are being designed developed according practical application requirements. In this review, recent progress in their synthesis strategies multiple applications is summarized. Their involve processes a combination of two. include flexible strain supercapacitors, actuators, adhesives, wound healing, drug delivery, tumor treatment, 3D printing, etc. Finally, current challenges, future development, opportunities discussed.

Язык: Английский

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A self-healing hydrogel based on crosslinked hyaluronic acid and chitosan to facilitate diabetic wound healing

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 220, С. 326 - 336

Опубликована: Авг. 18, 2022

Язык: Английский

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Mussel-Inspired Multifunctional Hydrogels with Adhesive, Self-Healing, Antioxidative, and Antibacterial Activity for Wound Healing

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(13), С. 16515 - 16525

Опубликована: Март 23, 2023

Antibacterial hydrogel wound dressings with adhesive and antioxidant activity are desirable for treating skin injuries in clinical care. Hereby, a series of multifunctional high adhesive, self-healing, antioxidant, antibacterial were designed fabricated using dopamine (DA) quercetin (QT). The hydrogels constructed by the interpenetrated quaternized chitosan chain segments polyacrylamide network. catechol groups on DA, QT, quaternary ammonium system endow strength, excellent adhesion, self-healing ability. results confirmed admirable hemocompatibility remarkable multifunction against Staphylococcus aureus Escherichia coli. Consequently, satisfactory appropriate alternative materials fields tissue dressing applications.

Язык: Английский

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Chitosan-based self-healing hydrogel dressing for wound healing

Advances in Colloid and Interface Science, Год журнала: 2024, Номер 332, С. 103267 - 103267

Опубликована: Авг. 3, 2024

Язык: Английский

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