Biomacromolecules,
Год журнала:
2024,
Номер
26(1), С. 670 - 678
Опубликована: Дек. 19, 2024
Hydrogel
three-dimensional
(3D)
printing
has
emerged
as
a
highly
valuable
fabrication
tool
for
applications
ranging
from
electronics
and
biomedicine.
While
conventional
hydrogels
such
gelatin,
alginate,
hyaluronic
acid
satisfy
biocompatibility
requirements,
they
distinctly
lack
reproducibility
in
terms
of
mechanical
properties
3D
printability.
Aiming
to
offer
high-performance
alternative,
here
we
present
range
amphiphilic
star-shaped
diblock
copolypeptides
l-glutamate
l-leucine
residues
with
different
topologies.
Hydrophobic
side
chains
the
polymer
block
drive
conformational
self-assembly
water,
spontaneously
forming
tunable
properties,
through
variation
star
topology.
Their
amenable
shear-thinning
self-recovery
render
them
suitable
hydrogel
inks
direct
ink
writing.
Well-defined
3D-printed
structures
can
be
readily
generated
rapidly
photo-cross-linked
using
visible
light
(405
nm)
after
methacrylamide
functionalization,
while
demonstrate
good
top-seeded
encapsulated
MC3T3
cells.
The Journal of Physical Chemistry A,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
This
study
evaluates
the
ability
of
GFN2-xTB
method
and
Conceptual
Density
Functional
Theory-derived
tools
to
predict
local
reactivity
in
large
systems.
Carbon-based
systems
such
as
C60,
C70,
Li+@C70,
C240,
C360,
C648,
C720
have
been
used
test
sets,
orbital-weighted
dual
descriptor
was
employed
identify
nucleophilic
electrophilic
regions,
providing
a
comprehensive
analysis
their
patterns.
The
results
confirm
that
accurately
reproduces
profiles
observed
experimentally
at
DFT
level,
particularly
well-known
fullerenes
like
C60
C70.
addition
an
endohedral
Li+
cation
C70
demonstrated
enhanced
electrophilicity
reduced
unfavorable
consistent
with
previous
studies.
For
larger
less-studied
systems,
C720,
revealed
distinct
features,
including
localization
regions
−C≡C–
units
C240/C648,
ends
C360
nanoparticle
model,
emergence
zones
due
reduction
aromaticity
benzenoid
rings
C720.
These
findings
validate
computationally
efficient
alternative
for
exploring
structures
contribute
valuable
insights
into
potential
applications
molecular
design
material
science
nanotechnology.
Soft Materials,
Год журнала:
2025,
Номер
unknown, С. 1 - 16
Опубликована: Март 24, 2025
Hydrogel
materials
have
a
variety
of
applications,
ranging
from
biomedical
and
drug
delivery
systems,
to
their
employment
as
immobilization
matrices
in
bioprocessing
applications.
Polyvinyl
alcohol
(PVA)
is
synthetic,
water-soluble,
biocompatible
polymer.
Due
its
physical
properties
when
gelled,
this
polymer
has
been
highlighted
suitable
candidate
for
application
the
industry
an
matrix
microorganisms.
This
study
investigates
effects
using
various
polyols
co-solvent
on
gelation
PVA-based
hydrogels
formed
at
ambient
conditions,
resulting
properties.
In
addition
glycerol,
previously
known
capabilities
improve
used
co-solvent,
including
erythritol
(C4H10O4),
xylitol
(C5H12O5),
sorbitol
(C6H14O6)
were
investigated.
Key
investigated,
including:
transparency;
tensile
compressive
strengths;
diffusion
coefficients;
rates
gelation;
method
gelation.
It
was
determined
that
are
through
crosslinking
rather
than
chemical
crosslinking.
The
glycerol-PVA
tended
exhibit
more
photosynthetic
organisms,
although
differences
between
glycerol-PVA,
xylitol-PVA,
sorbitol-PVA
comparable
often
not
significantly
different
after
rehydration.
investigation
showed
simple
polyols,
solid
could
be
conditions
without
requirement
cytotoxic
chemicals,
harsh
or
unfavorable
intermediate
chemicals.
Proceedings of the National Academy of Sciences,
Год журнала:
2025,
Номер
122(18)
Опубликована: Май 1, 2025
Stimuli-responsive
engineered
living
materials
(ELMs)
can
respond
to
environmental
or
biochemical
cues
and
have
broad
utility
in
biological
sensors
machines,
but
traditionally
been
limited
biocompatible
scaffolds.
This
is
because
they
are
typically
made
by
mixing
cells
into
a
precursor
solution
before
crosslinking.
Here,
we
demonstrate
diffusion
mechanism
for
incorporating
of
the
cyanobacterium
Synechococcus
elongatus
sp.
PCC
7942
(S.
elongatus)
nanoclay-poly-N-isopropylacrylamide
(NC-PNIPAm),
hydrogel
with
cytotoxic
precursor,
exploiting
its
temperature-dependent
shape-morphing
behavior.
Subsequent
growth
S.
caused
decrease
bending
curvature
stiffness
(local
Young's
modulus)
NC-PNIPAm
due
partial
degradation
an
unannotated
enzyme.
Creation
observation
this
cyanobacteria-hydrogel
ELM
showcases
method
diffusing
as
well
characterizing
extracellular
Beni-Suef University Journal of Basic and Applied Sciences,
Год журнала:
2025,
Номер
14(1)
Опубликована: Май 26, 2025
Abstract
Background
Acrylamide
(AA),
a
probable
human
carcinogen
(Group
2A)
classified
by
the
International
Agency
for
Research
on
Cancer
(IARC),
has
emerged
as
significant
food
safety
concern
worldwide.
Its
formation
during
high-temperature
cooking
processes,
such
frying,
baking,
and
roasting
of
starchy
foods,
spurred
extensive
research
efforts
to
understand
its
toxicity
develop
effective
mitigation
strategies.
This
study
aims
provide
comprehensive
bibliometric
analysis
scientific
literature
AA
metabolite,
glycidamide
(GA),
published
from
1965
end
2024,
focusing
evolving
trends
emphasis
related
their
in
food.
Results
A
3729
Scopus
articles
was
conducted
using
VOSviewer.
The
revealed
general
increase
number
annual
publications
AA.
Most
studies
focused
various
types
associated
with
AA,
neurotoxicity,
cytotoxicity,
nephrotoxicity,
utilizing
different
models.
findings
indicate
growing
mitigate
foods
response
toxicity.
Conclusions
concludes
that
both
quality
quantity
have
significantly
improved
over
time,
an
anticipated
continued
future
research.
trend
reflects
ongoing
global
about
AA’s
importance
developing
strategies
reduce
presence
which
implications
public
health
safety.
Graphic
abstract
