The Gut‐Brain Axis in Parkinson disease: Emerging Concepts and Therapeutic Implications
Movement Disorders Clinical Practice,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Abstract
Background
The
gut‐brain
axis,
i.e.
the
bidirectional
communication
system
between
gut
and
brain,
has
become
of
central
importance
in
Parkinson
disease
(PD)
research
over
past
20
years.
Aims
We
aimed
to
describe
milestones
axis
PD
development
theories
proposing
involvement
gastrointestinal
tract
pathogenesis.
Methods
searched
PubMed
using
terms
‘gut‐brain
axis’
AND
‘Parkinson
disease’,
selected
relevant
articles
provide
foundation
for
reconstructing
an
historical
overview
PD.
Results
Mounting
evidence
from
preclinical,
clinical
post‐mortem
studies
suggests
that
a
subgroup
patients
present
with
range
prodromal
symptoms
(e.g.,
autonomic
dysfunction,
rapid
eye
movement
sleep
behaviour
disorder)
which
reflect
initial
accumulation
later
spread
pathological
α‐synuclein
rostrally
(“body‐first”
PD).
Through
neural
connections
along
may
producing
clinically
manifest
disease.
Recently,
two
mechanisms
involving
have
attracted
increasing
attention
their
role
pathogenesis
progression,
namely
perturbation
composition
microorganisms
living
(the
microbiome),
dysfunction
enteroendocrine
cells.
Conclusion
Treatments
targeting
especially
microbiome
cells
pathway,
could
potentially
slow
progression
or
even
prevent
onset.
Among
these,
pre/probiotics,
faecal
microbiota
transplantation,
glucagon‐like
peptide‐1
receptor
agonists,
entered
advanced
stages
trials
humans
shown
potential
symptomatic
disease‐modifying
effects.
Язык: Английский
Curli protein: A potential contributor to α-synucleopathy in Parkinson's disease
Translational Medicine of Aging,
Год журнала:
2025,
Номер
9, С. 41 - 48
Опубликована: Янв. 1, 2025
Язык: Английский
The gut–brain axis in early Parkinson’s disease: from prodrome to prevention
Journal of Neurology,
Год журнала:
2025,
Номер
272(6)
Опубликована: Май 21, 2025
Abstract
Parkinson’s
disease
is
the
second
most
common
neurodegenerative
disorder
and
fastest
growing
neurological
condition
worldwide,
yet
its
etiology
progression
remain
poorly
understood.
This
characterized
pathologically
by
prion-like
spread
of
misfolded
neuronal
alpha-synuclein
proteins
in
specific
brain
regions
leading
to
Lewy
body
formation,
neurodegeneration,
progressive
impairment.
It
unclear
what
triggers
where
α-synuclein
protein
aggregation
begins,
although
proposed
induction
sites
include
olfactory
bulb
dorsal
motor
nucleus
vagus
nerve.
Within
last
20
years,
there
has
been
increasing
evidence
that
could
be
triggered
early
microbiome
changes
accumulation
gastrointestinal
system.
Gut
microbiota
dysbiosis
alters
motility,
permeability,
inflammation
enable
from
gut-to-brain
via
enteric
nervous
Individuals
with
isolated
rapid
eye
movement
sleep
behavior
have
a
high
likelihood
developing
might
represent
prodromal
‘gut-first’
subtype
condition.
The
gut-first
model
offers
novel
gut-based
therapeutic
avenues,
such
as
anti-,
pre-,
pro-biotic
preparations
fecal
transplants.
Crucially,
interventions
offer
an
avenue
treat
at
stages
aim
mitigating
evolution
clinically
recognizable
Язык: Английский
Molecular Insights into the Impact of Environmental Pollution on Gut Microbiota and short chain fatty acids (SCFA) Mediated Metabolic Dysregulation- A Review
Medicine in Microecology,
Год журнала:
2025,
Номер
unknown, С. 100133 - 100133
Опубликована: Май 1, 2025
Язык: Английский