Enzyme-Powered Porous Micromotors Built from a Hierarchical Micro- and Mesoporous UiO-Type Metal–Organic Framework

Journal of the American Chemical Society, Год журнала: 2020, Номер 142(50), С. 20962 - 20967

Опубликована: Дек. 4, 2020

Here, we report the design, synthesis, and functional testing of enzyme-powered porous micromotors built from a metal-organic framework (MOF). We began by subjecting presynthesized microporous UiO-type MOF to ozonolysis, confer it with mesopores sufficiently large adsorb host enzyme catalase (size: 6-10 nm). then encapsulated inside mesopores, observing that they are hosted in those located at subsurface crystals. In presence H2O2 fuel, motors (or MOFtors) exhibit jet-like propulsion enabled enzymatic generation oxygen bubbles. Moreover, thanks their hierarchical pore system, MOFtors retain sufficient free space for adsorption additional targeted species, which validated MOFtor removal rhodamine B during self-propulsion.

Язык: Английский

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Ultrasonically Propelled Micro‐ and Nanorobots

Advanced Functional Materials, Год журнала: 2021, Номер 32(5)

Опубликована: Окт. 20, 2021

Abstract Ultrasound at sufficiently low amplitudes, specifically in the MHz frequency range, does little harm to biological samples (such as cells and tissues) provides an advantageous well‐controlled means efficiently power microswimmers. In this review, a state‐of‐the‐art overview of ultrasonically propelled micro‐ nanorobots from perspective chemistry, physics, materials science is given. First, well‐established theory ultrasound propulsion for micro/nanorobots introduced. Second, setup designs are classified. Following this, presentative fabrication methods ultrasonic summarized detail. After mechanisms explored discussed. The hybrid motion magnetic‐, light‐, catalytic‐driven with actuation then Subsequently, review highlights discusses representative potential applications ultrasound‐powered functional biomedical, environmental, other relevant fields. Lastly, presents future outlook on ultrasound‐driven micro/nanorobots.

Язык: Английский

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Increasingly Intelligent Micromachines

Annual Review of Control Robotics and Autonomous Systems, Год журнала: 2022, Номер 5(1), С. 279 - 310

Опубликована: Янв. 5, 2022

Intelligent micromachines, with dimensions ranging from a few millimeters down to hundreds of nanometers, are miniature systems capable performing specific tasks autonomously at small scales. Enhancing the intelligence micromachines tackle uncertainty and variability in complex microenvironments has applications minimally invasive medicine, bioengineering, water cleaning, analytical chemistry, more. Over past decade, significant progress been made construction intelligent evolving simple soft, compound, reconfigurable, encodable, multifunctional, integrated as well individual multiagent, multiscale, hierarchical, self-organizing, swarm micromachines. The field leverages two important trends robotics research—the miniaturization intelligentization machines—but compelling combination these features yet be realized. core technologies required make such tiny machines include information media, transduction, processing, exchange, energy supply, but embedding all functions into system micro- or nanoscale is challenging. This article offers comprehensive introduction state-of-the-art used create for provides insight next-generation that can adapt diverse scenarios use emerging fields.

Язык: Английский

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Magnetically Actuated Medical Robots: An in vivo Perspective

Proceedings of the IEEE, Год журнала: 2022, Номер 110(7), С. 1028 - 1037

Опубликована: Апрель 28, 2022

The use of magnetic fields and field gradients to move material devices within the human body has a surprisingly long history. Over past two decades, there been renewed interest in this area with growth medical microrobots. In article, we focus on state-of-the-art future directions for magnetically actuated robots from an in vivo perspective. We initially review history relevant physics followed by discussion limited research efforts that investigate guided devices. Our is tethered probes, untethered (microrobots nanorobots), navigation systems have or could be utilized provide increased control safety physician patient.

Язык: Английский

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Hydrogen‐Powered Microswimmers for Precise and Active Hydrogen Therapy Towards Acute Ischemic Stroke

Advanced Functional Materials, Год журнала: 2021, Номер 31(19)

Опубликована: Фев. 4, 2021

Abstract Biodegradable microswimmers offer great potential for minimally invasive targeted therapy due to their tiny scale, multifunctionality, and versatility. However, most of the reported systems focused on proof‐of‐concept in vitro level. Here, successful fabrication facile hydrogen‐powered (HPMs) precise active acute ischemic stroke is demonstrated. The hydrogen (H 2 ) generated locally from designed magnesium (Mg) microswimmer functions not only as a propellant motion, but also an ingredient reactive oxygen species (ROS) inflammation scavenging. Due continuous detachment produced H , motion results delivery that allows enhanced extracellular intracellular reducibility. With help stereotaxic apparatus device, HPMs were injected precisely into lateral ventricle middle cerebral artery occlusion (MCAO) rats. By scavenging ROS via MCAO rats exhibit significant decrease infarct volume, improved spatial learning memory capability with minimal adverse effects, demonstrating efficient efficacy anti‐ischemic stroke. as‐developed excellent biocompatibility holds promise treatment or other oxidative stress induced diseases clinic near future.

Язык: Английский

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Nano-bio-interface engineering of metal-organic frameworks

Nano Today, Год журнала: 2021, Номер 40, С. 101256 - 101256

Опубликована: Июль 20, 2021

Язык: Английский

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Biodegradable Small‐Scale Swimmers for Biomedical Applications

Advanced Materials, Год журнала: 2021, Номер 33(42)

Опубликована: Сен. 3, 2021

Most forms of biomatter are ephemeral, which means they transform or deteriorate after a certain time. From this perspective, implantable healthcare devices designed for temporary treatments should exhibit the ability to degrade and either blend in with healthy tissues, be cleared from body minimal disruption accomplishing their designated tasks. This topic is currently being investigated field biomedical micro- nanoswimmers. These tiny have move through fluids by converting physical chemical energy into motion. Several architectures these been mimic motion strategies nature's motile microorganisms cells. Due abilities, proposed as minimally invasive tools precision applications. Hence, natural progression produce structures that can adopt, even surpass, similar transient features biological systems. The fate small-scale swimmers therapeutic mission critical successful translation swimmers' technologies clinical In review, recent research efforts summarized on biodegradable nanoswimmers applications, focus targeted delivery.

Язык: Английский

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Near-Infrared Light-Driven Shape-Programmable Hydrogel Actuators Loaded with Metal–Organic Frameworks

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(9), С. 11834 - 11841

Опубликована: Фев. 22, 2022

Shape-programmable hydrogel-based soft actuators that can adaptively respond to external stimuli are of paramount significance for the development bioinspired aquatic smart robots. Herein, we report design and synthesis near-infrared (NIR) light-driven hydrogel through in situ photopolymerization poly(N-isopropylacrylamide) (PNIPAM) hydrogels loaded with metal-organic frameworks (MOFs) onto surface poly(dimethylsiloxane) (PDMS) thin film. The MOFs not only function as an excellent photothermal nanotransducer but also accelerate adsorption/desorption water due their porous nanostructure, which speeds up response rate actuators. fabricated by tailoring patterning PDMS film, thus different shape-morphing modes such directional bending chiral twisting observed under NIR light irradiations. As proof-of-concept demonstrations, artificial hand, biomimetic mimosa, flower conceptualized MOF-containing Interestingly, able achieve octopus-inspired swimmer upon cyclic illumination fast photoresponsiveness as-prepared This work offer insights fabricating programmable reconfigurable actuators, shining a into potential applications emerging fields including robots, biomedical devices, beyond.

Язык: Английский

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Self‐Propelled Micro‐/Nanomotors as “On‐the‐Move” Platforms: Cleaners, Sensors, and Reactors

Advanced Functional Materials, Год журнала: 2021, Номер 32(10)

Опубликована: Ноя. 25, 2021

Abstract Artificial micro‐/nanomotors (MNMs) are tiny apparatuses that can autonomously navigate and perform specific tasks at micro‐/nanoscale. The continuous movement characteristics of MNMs related motion‐induced micromixing effect enable these devices to act as “on‐the‐move” cleaners, sensors, reactors facilitate corresponding chemical/physical processes. With reasonable design surface functionalization, show great promise in environmental, sensing, chemical applications. This review conveys the current propulsion strategies MNMs, with focus on their capabilities accelerating Representative applications environmental remediation, detection, conversion discussed, emphasizing highlighting role moving aspects. Finally, main challenges existing limitations translating potential into real‐world along future opportunities this field.

Язык: Английский

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Large‐Scale Self‐Assembly of MOFs Colloidosomes for Bubble‐Propelled Micromotors and Stirring‐Free Environmental Remediation

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(46)

Опубликована: Сен. 19, 2022

The design of MOF-based micromotors (MOFtors) is still challenging and with limited approaches, especially for the MOF nanoparticles (NPs). Herein, we report a universal straightforward strategy to efficiently self-assembly NPs into robust MOFtors enhanced organic- or heavy-metal-ion-contaminants remediation without mechanical stirring. Based on transient Pickering emulsion method, Fe3 O4 @NH2 -UiO-66 (Fe-UiO) are rapidly self-assembled colloidosomes (Fe-UiOSomes) large scale, formation mechanism systematically studied. Fe-UiOSomes-Pt through chemical reduction (Micromotor-C) presented higher motility 450±180 μm s-1 in 5 wt% H2 O2 aqueous solution. Finally, bubble-propelled Micromotor-C was employed remove dyes heavy metal ions (94 % MO 91 CrVI ).

Язык: Английский

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