Chinese Journal of Chemistry,
Год журнала:
2022,
Номер
40(12), С. 1407 - 1412
Опубликована: Фев. 23, 2022
Comprehensive
Summary
A
highly
enantioselective
gold‐catalyzed
intermolecular
[3
+
2]
cycloaddition
of
N
‐allenamides
with
nitrones
was
realized
by
the
application
Ming‐Phos
M6
as
a
chiral
ligand.
Both
enantiomers
cycloadducts
opposite
configuration
could
be
obtained
in
high
yields
regio‐
and
enantioselectivity
employment
either
diastereomer
The
acidic
N—H
bond
(hydrogen
bonding)
sulfinamide
moiety
pentaflurophenyl
substituent
(fluorine
effect)
may
play
important
roles
enhancement
enantioselectivity,
that
is,
is
multifunctional
ligand
this
transformation.
Organic Letters,
Год журнала:
2024,
Номер
26(13), С. 2651 - 2655
Опубликована: Март 22, 2024
An
electrocatalytic
approach
to
access
structurally
significant
azabicyclic
scaffolds
from
N-allyl
enamine
carboxylates
is
illustrated.
This
metal-free
method
functions
exclusively
with
a
catalytic
amount
of
iodide,
strategically
employed
electrochemically
generate
reactive
hypervalent
iodine
species,
which
facilitates
the
cascade
bicyclization
processes
enhanced
precision
and
efficiency.
Excellent
functional
group
compatibility
was
observed,
enabling
synthesis
series
azabicycle
derivatives.
Detailed
mechanistic
electrochemical
studies
enhance
comprehension
reaction
sequence.
Organic Letters,
Год журнала:
2021,
Номер
23(15), С. 5831 - 5835
Опубликована: Июль 19, 2021
Herein,
we
report
on
the
tris(pentafluorophenyl)borane-catalyzed
reaction
of
carbazole
heterocycles
with
aryldiazoacetates.
We
could
demonstrate
that
selective
N–H
functionalization
occurs
in
case
an
unprotected
carbazole,
other
N-heterocycles,
and
secondary
amines
good
yields.
In
contract,
protected
undergoes
C–H
at
C-3
position
a
yield.
The
application
both
approaches
was
studied
41
examples
up
to
97%
ACS Omega,
Год журнала:
2022,
Номер
7(8), С. 6944 - 6955
Опубликована: Фев. 15, 2022
The
first
gold(I)-catalyzed
cycloisomerization
procedure
applied
to
the
synthesis
of
substituted
4H-benzo[d][1,3]oxazines
has
been
developed
starting
from
N-(2-alkynyl)aryl
benzamides.
chemoselective
oxygen
cyclization
via
6-exo-dig
pathway
yielded
observed
heterocycles
in
modest
good
chemical
yields
under
very
mild
reaction
conditions.
obtained
oxazines
were
assayed
on
breast
cancer
(BC)-derived
cell
lines
MCF-7
and
HCC1954
with
differential
biological
activity.
newly
synthesized
4H-benzo[d][1,3]oxazine
compounds
showed
several
degrees
proliferation
inhibition
a
remarkable
effect
for
those
having
aryl
at
C-2
molecules.
an
IC50
ranking
3.1
95
μM
cells.
These
represent
potential
drug
candidates
BC
treatment.
However,
additional
assays
are
needed
elucidate
their
complete
over
cellular
molecular
hallmarks
cancer.
Chemistry - An Asian Journal,
Год журнала:
2022,
Номер
17(24)
Опубликована: Окт. 18, 2022
Gold
catalysis
is
an
extremely
enthusiastic
field
of
investigation
in
the
area.
The
development
alternative,
highly
inventive,
precompetitive
techniques
based
on
gold
has
paved
way
for
executing
a
broad
spectrum
chemical
transformations
from
uncomplicated
starting
materials.
total
synthesis
natural
products
complex
and
more
complicated
task.
An
amalgamation
product
through
gold-catalysis
been
thought-provoking
job.
protocol
solved
several
problems
related
to
numerous
products.
Thus,
this
review
outlined
some
most
notable
benchmarks
last
seven
years
(2015-2021)
their
application
strategy
acquired
by
authors
accomplish
will
be
elaborately
discussed
emphasizing
role
gold-catalyzed
reactions.
Chinese Journal of Chemistry,
Год журнала:
2022,
Номер
40(12), С. 1407 - 1412
Опубликована: Фев. 23, 2022
Comprehensive
Summary
A
highly
enantioselective
gold‐catalyzed
intermolecular
[3
+
2]
cycloaddition
of
N
‐allenamides
with
nitrones
was
realized
by
the
application
Ming‐Phos
M6
as
a
chiral
ligand.
Both
enantiomers
cycloadducts
opposite
configuration
could
be
obtained
in
high
yields
regio‐
and
enantioselectivity
employment
either
diastereomer
The
acidic
N—H
bond
(hydrogen
bonding)
sulfinamide
moiety
pentaflurophenyl
substituent
(fluorine
effect)
may
play
important
roles
enhancement
enantioselectivity,
that
is,
is
multifunctional
ligand
this
transformation.
