Applied Catalysis B Environment and Energy, Год журнала: 2023, Номер 337, С. 122995 - 122995
Опубликована: Июнь 15, 2023
Язык: Английский
Military Medical Research, Год журнала: 2021, Номер 8(1)
Опубликована: Сен. 9, 2021
Abstract The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution antibiotic resistant bacteria. As an excellent candidate overcome resistance, antimicrobial peptides (AMPs) that are produced from synthetic and natural sources demonstrate broad-spectrum activity with high specificity low toxicity. These possess distinctive structures functions by employing sophisticated mechanisms action. This comprehensive review provides broad overview AMPs origin, structural characteristics, action, biological activities applications. We finally discuss strategies optimize develop AMP-based treatment as potential anticancer therapeutics.
Язык: Английский
Процитировано
745
Chemical Science, Год журнала: 2021, Номер 13(2), С. 345 - 364
Опубликована: Дек. 16, 2021
This review surveys the structure–activity of advanced antimicrobial cationic polymers with low toxicity and high selectivity. Their uses as potentiating adjuvants antibiofilm agents are also covered.
Язык: Английский
Процитировано
120
Nano Letters, Год журнала: 2023, Номер 23(9), С. 3929 - 3938
Опубликована: Апрель 27, 2023
Manufacturing heteronanostructures with specific physicochemical characteristics and tightly controllable designs is very appealing. Herein, we reported NIR-II light-driven dual plasmonic (AuNR-SiO2-Cu7S4) antimicrobial nanomotors an intended Janus configuration through the overgrowth of copper-rich Cu7S4 nanocrystals at only one high-curvature site Au nanorods (Au NRs). These were applied for photoacoustic imaging (PAI)-guided synergistic photothermal photocatalytic treatment bacterial infections. Both performance activity are dramatically improved owing to strong plasmon coupling between NRs component enhanced energy transfer. The motion behavior promotes transdermal penetration enhances matter–bacteria interaction. More importantly, directional navigation could be synchronously driven by light. marriage active antibacterial resulted in expected good effects abscess infection mouse model.
Язык: Английский
Процитировано
48
Journal of the American Chemical Society, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
The rapid emergency and spread of antimicrobial-resistant (AMR) bacteria the lack new antibiotics being developed pose serious threats to global healthcare system. Therefore, development more effective therapies overcome AMR is highly desirable. Metal ions have a long history serving as antimicrobial agents, metal-based compounds are now attracting interest from scientific communities in fight against owing their unique mechanism. Moreover, they may also serve antibiotic adjuvants enhance efficacy clinically used antibiotics. In this perspective, we highlight important showcase studies last 10 years on strategies crisis. Specifically, categorize these metallo-antimicrobials into five classes based modes action (i.e., metallo-enzymes metal-binding enzyme inhibitors, membrane perturbants, uptake/efflux system inhibitors/regulators, persisters oxidative stress inducers). significant advantages over traditional lie multitargeted mechanisms, which render less likelihood generate resistance. However, notice that such raise concern potential side effects low selectivity toward pathogens host, appears be biggest obstacle for downstream translational research. We anticipate combination therapy through repurposing (metallo)drugs with optimization absorption route formulation achieve target-oriented delivery will powerful way combat AMR. Despite challenges, hold great opportunities therapeutic intervention infection by resistant bacteria.
Язык: Английский
Процитировано
3
Applied Materials Today, Год журнала: 2021, Номер 25, С. 101192 - 101192
Опубликована: Сен. 27, 2021
Язык: Английский
Процитировано
72
Current Opinion in Microbiology, Год журнала: 2023, Номер 75, С. 102347 - 102347
Опубликована: Июль 17, 2023
The mounting burden of antimicrobial resistance (AMR) is one the most concerning threats to public health worldwide. With low economic incentives and a dwindling supply new drugs in clinical pipelines, more innovative approaches novel drug design development are desperately required. Metal-based compounds rapidly emerging as an alternative organic drugs, they have ability kill pathogens via metal-specific modes action. We herein review recent advances metal-based antibacterial agents, including metal complexes, ions catalytic metallodrugs. concludes with perspective on rational antibiotics, how we can exploit their unique properties tackle AMR.
Язык: Английский
Процитировано
44
Drug Resistance Updates, Год журнала: 2023, Номер 72, С. 101030 - 101030
Опубликована: Ноя. 30, 2023
Язык: Английский
Процитировано
27
The Microbe, Год журнала: 2024, Номер 2, С. 100051 - 100051
Опубликована: Фев. 29, 2024
Antimicrobial peptides (AMPs) are low-molecular-weight that demonstrate a broad range of antimicrobial and immunomodulatory effects against bacteria, viruses, yeasts, fungi, cytotoxic cancer cells. Natural AMPs typically have positive charge contain fewer than 100 amino acids, along with amphipathic properties. obtained from numerous sources, like humans, animals, plants, etc., where they act as significant part the innate immune system provide first-line protection pathogenic microorganisms. As result, since separate mechanisms conventional antibiotics, can be best choice for drug-resistant microbial treatment. The tablet, capsule, solution inconvenient when given orally due to peptide degradation lower absorption in gastrointestinal tract. Novel drug delivery systems formulations been developed showed increased activity compared single AMP. Special nanocarriers, hydrogels, cubosomes, wafers, dry powder inhalers, creams, mouth rinse established help prevent some major barriers clinical applications, such cytotoxicity, bioavailability, stability. In our review studies, we discussing formulation by classification, different benefits limitations various methods, their applications.
Язык: Английский
Процитировано
18
ACS Applied Bio Materials, Год журнала: 2024, Номер 7(4), С. 2023 - 2035
Опубликована: Март 27, 2024
The rising prevalence of multiple-drug-resistant pathogens poses a formidable challenge to conventional antimicrobial treatments. inability potent antibiotics combat these "superbugs" underscores the pressing need for alternative therapeutic agents. Antimicrobial peptides (AMPs) represent an class antibiotics. AMPs are essential immunomodulatory molecules that found in various organisms. They play pivotal role managing microbial ecosystems and bolstering innate immunity by targeting eliminating invading microorganisms. also have applications agriculture sector combating animal as well plant pathogens. can be exploited targeted therapy diseases used drug-delivery systems. synergy with current treatments like potentially lead lower required dosage. huge potential wound healing regenerative medicine. Developing AMP-based strategies improved safety, specificity, efficacy is crucial battle against alarming global resistance. This review will explore AMPs' increasing applicability, their mode activity, delivery systems enhancing stability efficacy.
Язык: Английский
Процитировано
14
Materials Horizons, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Infection is the most prevalent complication of fractures, particularly in open and often leads to severe consequences.
Язык: Английский
Процитировано
11