Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry

Chemical Reviews, Год журнала: 2021, Номер 122(2), С. 2752 - 2906

Опубликована: Авг. 10, 2021

Photoinduced chemical transformations have received in recent years a tremendous amount of attention, providing plethora opportunities to synthetic organic chemists. However, performing photochemical transformation can be quite challenge because various issues related the delivery photons. These challenges barred widespread adoption steps industry. past decade, several technological innovations led more reproducible, selective, and scalable photoinduced reactions. Herein, we provide comprehensive overview these exciting advances, including flow chemistry, high-throughput experimentation, reactor design scale-up, combination photo- electro-chemistry.

Язык: Английский

---

Deuterium in drug discovery: progress, opportunities and challenges

Nature Reviews Drug Discovery, Год журнала: 2023, Номер 22(7), С. 562 - 584

Опубликована: Июнь 5, 2023

Язык: Английский

---

Insights into the solvation chemistry in liquid electrolytes for lithium-based rechargeable batteries

Chemical Society Reviews, Год журнала: 2023, Номер 52(15), С. 5255 - 5316

Опубликована: Янв. 1, 2023

Lithium-based rechargeable batteries have dominated the energy storage field and attracted considerable research interest due to their excellent electrochemical performance. As indispensable ubiquitous components, electrolytes play a pivotal role in not only transporting lithium ions, but also expanding stable potential window, suppressing side reactions, manipulating redox mechanism, all of which are closely associated with behavior solvation chemistry electrolytes. Thus, comprehensively understanding is significant importance. Here we critically reviewed development various lithium-based including lithium-metal (LMBs), nonaqueous lithium-ion (LIBs), lithium-sulfur (LSBs), lithium-oxygen (LOBs), aqueous (ALIBs), emphasized effects interactions between cations, anions, solvents on chemistry, functions different types (strong solvating electrolytes, moderate weak electrolytes) performance mechanism abovementioned batteries. Specifically, stability electrode-electrolyte interphases, suppression dendrites LMBs, inhibition co-intercalation LIBs, improvement anodic at high cut-off voltages LIBs ALIBs, regulation pathways LSBs LOBs, hydrogen/oxygen evolution reactions LOBs thoroughly summarized. Finally, review concludes prospective outlook, where practical issues advanced situ/operando techniques illustrate theoretical calculation simulation such as "material knowledge informed machine learning" "artificial intelligence (AI) + big data" driven strategies for high-performance been proposed.

Язык: Английский

---

Fluorine-containing pharmaceuticals approved by the FDA in 2020: Synthesis and biological activity

Chinese Chemical Letters, Год журнала: 2021, Номер 32(11), С. 3342 - 3354

Опубликована: Май 27, 2021

Язык: Английский

---

Perspectives on Improving the Safety and Sustainability of High Voltage Lithium‐Ion Batteries Through the Electrolyte and Separator Region

Advanced Energy Materials, Год журнала: 2022, Номер 12(23)

Опубликована: Май 6, 2022

Abstract Lithium‐ion batteries (LIBs) are promising candidates within the context of development novel battery concepts with high energy densities. Batteries operating potentials or voltage (HV) LIBs (>4.2 V vs Li + /Li) can provide densities and therefore attractive in high‐performance LIBs. However, a variety challenges (including solid electrolyte interface (SEI), lithium plating, etc.) related safety issues (such as gas formation thermal runaway effects) must be solved for practical, widespread application HV‐LIBs. Most these arise region between electrodes: region. This review provides an overview recent progress on region, including liquid electrolytes, ionic liquids, gel polymer separators, electrolytes HV‐LIBs applications. A focus improving systems, some perspectives their relative cost environmental impact, is given. Overall, new information encouraging HV‐LIBs, this serves guide potential strategies to improve safety, allowing solid‐state batteries, accelerated practical relevance.

Язык: Английский

---

Fluorine-containing drugs approved by the FDA in 2021

Chinese Chemical Letters, Год журнала: 2022, Номер 34(1), С. 107578 - 107578

Опубликована: Июнь 3, 2022

Язык: Английский

---

Efficient Recognition and Removal of Persistent Organic Pollutants by a Bifunctional Molecular Material

Journal of the American Chemical Society, Год журнала: 2022, Номер 145(1), С. 260 - 267

Опубликована: Дек. 20, 2022

Persistent organic pollutants (POPs) exist widely in the environment and place significant impact on human health by bioaccumulation. Efficient recognition of POPs their removal are highly challenging tasks because specific structures interact often very weakly with capture materials. Herein, a molecular nanocage (1) is studied as an efficient sensing sorbent material for POPs, which demonstrated representative stable perfluorooctane sulfonate (PFOS) substrate containing hydrophilic sulfonic group hydrophobic fluoroalkyl chain. A sensitive unusual turn-on fluorescence response within 10 s 97% total PFOS from water 20 min have been achieved owing to strong host–guest interactions between 1 PFOS. The binding constant 2 orders magnitude higher than state-of-the-art adsorbents thus represents new benchmark interaction has elucidated solid-state NMR spectroscopy single-crystal X-ray diffraction, provide key insights at level design advanced sensing/sorbent materials POPs.

Язык: Английский

---

In-Cell Structural Biology by NMR: The Benefits of the Atomic Scale

Chemical Reviews, Год журнала: 2022, Номер 122(10), С. 9497 - 9570

Опубликована: Март 31, 2022

In-cell structural biology aims at extracting information about proteins or nucleic acids in their native, cellular environment. This emerging field holds great promise and is already providing new facts outlooks of interest both fundamental applied levels. NMR spectroscopy has important contributions on this stage: It brings a broad variety nuclei the atomic scale, which ensures its versatility uniqueness. Here, we detail methods, knowledge, applications biomedical engineering related to in-cell by NMR. We finally propose brief overview main other techniques (EPR, smFRET, cryo-ET, etc.) draw some advisable developments for In era large-scale screenings deep learning, accurate qualitative experimental evidence are as essential ever understand interior life cells. can generate such it does so scale. review meant deliver comprehensive but accessible information, with advanced technical details reflections nature results, future field.

Язык: Английский

---

Rational Design of Cellulosic Triboelectric Materials for Self-Powered Wearable Electronics

Nano-Micro Letters, Год журнала: 2023, Номер 15(1)

Опубликована: Май 11, 2023

With the rapid development of Internet Things and flexible electronic technologies, there is a growing demand for wireless, sustainable, multifunctional, independently operating self-powered wearable devices. Nevertheless, structural flexibility, long time, wearing comfort have become key requirements widespread adoption electronics. Triboelectric nanogenerators as distributed energy harvesting technology great potential application in sensing. Compared with rigid electronics, cellulosic electronics significant advantages terms breathability, functionality. In this paper, research progress advanced triboelectric materials reviewed. The interfacial characteristics cellulose are introduced from top-down, bottom-up, composite material preparation process. Meanwhile, modulation strategies properties presented. Furthermore, design such surface functionalization, structure design, vacuum-assisted self-assembly systematically discussed. particular, fields human harvesting, tactile sensing, health monitoring, human-machine interaction, intelligent fire warning outlined detail. Finally, current challenges future directions

Язык: Английский

---

Treatment technologies for removal of per- and polyfluoroalkyl substances (PFAS) in biosolids

Chemical Engineering Journal, Год журнала: 2022, Номер 453, С. 139964 - 139964

Опубликована: Окт. 22, 2022

Язык: Английский

---