Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Апрель 17, 2024
Abstract
Exploitation
of
noncovalent
interactions
for
recognition
an
organic
substrate
has
received
much
attention
the
design
metal
catalysts
in
synthesis.
The
CH–π
interaction
is
especially
interest
molecular
because
both
C–H
bonds
and
π
electrons
are
fundamental
properties
molecules.
However,
their
weak
nature,
these
have
been
less
utilized
control
reactions.
We
show
here
that
can
be
used
to
kinetically
accelerate
catalytic
activation
arenes
by
directly
recognizing
π-electrons
arene
substrates
with
a
spirobipyridine
ligand.
Computation
ligand
kinetic
isotope
effect
study
provide
evidence
between
backbone
substrate.
rational
exploitation
will
open
new
avenues
catalysis.
Chemical Society Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Differentiating
between
two
highly
similar
C-H
bonds
in
a
given
molecule
remains
fundamental
challenge
synthetic
organic
chemistry.
Directing
group
assisted
strategies
for
the
functionalisation
of
proximal
has
been
known
last
few
decades.
However,
distal
bond
is
strenuous
and
requires
distinctly
specialised
techniques.
In
this
review,
we
summarise
advancement
Pd-catalysed
C(sp
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 2, 2024
Abstract
Regioselective
arene
C−H
bond
alkylation
is
a
powerful
tool
in
synthetic
chemistry,
yet
subject
to
many
challenges.
Herein,
we
report
the
meta
-C−H
of
aromatics
bearing
N
-directing
groups
using
(hetero)aromatic
epoxides
as
alkylating
agents.
This
method
results
complete
regioselectivity
on
both
well
epoxide
coupling
partners,
cleaving
exclusively
benzylic
C−O
bond.
Oxetanes,
which
are
normally
unreactive,
also
participate
reagents
under
reaction
conditions.
Our
mechanistic
studies
reveal
an
unexpected
reversible
ring
opening
process
undergoing
catalyst-controlled
regioselection,
key
for
observed
high
regioselectivities.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(6), С. 4156 - 4164
Опубликована: Март 7, 2024
Metal
impurities
can
complicate
the
identification
of
active
catalyst
species
in
transition
metal
catalysis
and
electrocatalysis,
potentially
leading
to
misleading
findings.
This
study
investigates
influence
on
photocatalysis.
Specifically,
photocatalytic
reaction
inert
alkanes
using
chlorides
without
use
an
external
photocatalyst
was
studied,
achieving
successful
C(sp
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Апрель 17, 2024
Abstract
Exploitation
of
noncovalent
interactions
for
recognition
an
organic
substrate
has
received
much
attention
the
design
metal
catalysts
in
synthesis.
The
CH–π
interaction
is
especially
interest
molecular
because
both
C–H
bonds
and
π
electrons
are
fundamental
properties
molecules.
However,
their
weak
nature,
these
have
been
less
utilized
control
reactions.
We
show
here
that
can
be
used
to
kinetically
accelerate
catalytic
activation
arenes
by
directly
recognizing
π-electrons
arene
substrates
with
a
spirobipyridine
ligand.
Computation
ligand
kinetic
isotope
effect
study
provide
evidence
between
backbone
substrate.
rational
exploitation
will
open
new
avenues
catalysis.
