Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(43), С. 23794 - 23801
Опубликована: Окт. 18, 2023
Sacrificial
chemical
bonds
have
been
used
effectively
to
increase
the
toughness
of
elastomers
because
such
dissociate
at
forces
significantly
below
fracture
limit
primary
load-bearing
bonds,
thereby
dissipating
local
stress.
This
approach
owes
much
its
success
ability
adjust
threshold
force
which
sacrificial
fail
desired
rate,
for
example,
by
selecting
either
covalent
or
noncovalent
bonds.
Here,
we
report
experimental
and
computational
evidence
that
a
mechanical
bond,
responsible
structural
integrity
rotaxane
catenane,
increases
elastomer's
strain,
stress,
energy
as
bond
comparable
mechanochemical
dissociation
kinetics.
We
synthesized
studied
6
polyacrylates
cross-linked
difluorenylsuccinonitrile
(DFSN),
is
an
established
mechanochromic
moiety;
[2]rotaxane,
whose
stopper
allows
wheel
dethread
on
same
subsecond
time
scale
DFSN
dissociates
when
under
tensile
1.5-2
nN;
structurally
homologous
[2]rotaxane
with
bulkier
stable
>5.5
similarly
stoppered
[3]rotaxanes
containing
in
their
axles;
control
polymer
aliphatic
nonsacrificial
cross-links.
Our
data
suggest
dethreading
without
failure
any
may
be
important,
hitherto
unrecognized,
contributor
some
rotaxane-cross-linked
polymers
provide
mechanism
material
behavior
independently
response
networks,
due
distinct
relationships
between
structure
reactivity.
ACS Nano,
Год журнала:
2023,
Номер
17(23), С. 23223 - 23261
Опубликована: Дек. 2, 2023
Stimuli-responsive
polymers
can
respond
to
internal
stimuli,
such
as
reactive
oxygen
species
(ROS),
glutathione
(GSH),
and
pH,
biological
enzymes,
external
lasers
ultrasound,
etc.,
by
changing
their
hydrophobicity/hydrophilicity,
degradability,
ionizability,
thus
have
been
widely
used
in
biomedical
applications.
Due
the
characteristics
of
tumor
microenvironment
(TME),
stimuli-responsive
that
cater
specifically
TME
extensively
prepare
smart
nanovehicles
for
targeted
delivery
therapeutic
diagnostic
agents
tissues.
Compared
conventional
drug
nanosystems,
TME-responsive
nanosystems
many
advantages,
high
sensitivity,
broad
applicability
among
different
tumors,
functional
versatility,
improved
biosafety.
In
recent
years,
a
great
deal
research
has
devoted
engineering
efficient
polymeric
significant
improvement
made
both
cancer
diagnosis
therapy.
this
review,
we
summarize
some
advances
involving
use
polymer
nanocarriers
delivery,
imaging,
therapy,
theranostics.
Various
chemical
stimuli
will
be
described
context
nanosystems.
Accordingly,
groups
responsible
responsiveness
strategies
incorporate
these
into
discussed
detail.
With
on
topic
expending
at
fast
pace,
innovative
concepts,
sequential
cascade
release,
NIR-II
multifunctional
formulations,
emerged
popular
enhanced
performance,
which
also
included
here
with
up-to-date
illustrations.
We
hope
review
offer
valuable
insights
selection
optimization
help
accelerate
future
applications
treatment.
Materials Horizons,
Год журнала:
2023,
Номер
10(10), С. 3929 - 3947
Опубликована: Янв. 1, 2023
Self-healing
hydrogels
based
on
various
dynamic
interactions
are
comprehensively
summarized
and
their
biomedical
applications
also
thoroughly
elaborated.
Materials Horizons,
Год журнала:
2023,
Номер
10(8), С. 2968 - 2979
Опубликована: Янв. 1, 2023
Soft
self-healing
materials
are
crucial
for
the
development
of
next-generation
wearable
electronics
that
could
function
in
dynamic
environments
and
resist
mechanical
damage.
However,
several
challenges
remain,
including
fatigue
fracture,
poor
elasticity,
thermodynamic
lability,
which
significantly
limit
their
practical
applications.
Here,
with
a
model
system
soft
polyurea,
we
propose
molecular
engineering
strategy
transforming
inherently
fragile
an
island-like
structure
into
resilient
ones
bicontinuous
nanophase
separation
using
2-ureido-4-pyrimidinone
(UPy)
supramolecular
motifs
as
structural
regulators.
The
continuous
hard
domains
modified
by
UPy
formed
repairable
network
similar
to
those
reticular
layer
animal
dermis.
This
design
allows
simultaneous
tremendous
improvement
threshold
(34.8-fold
increase),
elastic
restorability
(the
maximum
elongation
full
dimensional
recovery
increasing
from
6
times
13
times),
stability
(4
orders
magnitude
characteristic
flow
transition
relaxation
time),
without
compromising
compliance,
autonomous
self-healing,
optical
transparency.
These
improvements
address
current
limitations
unfilled
reliable
substrates
transparent
strain-electronics.
Abstract
The
capacity
of
biological
tissues
to
undergo
self‐healing
is
crucial
for
the
performance
functions
and
continuation
life.
Conventional
intrinsic
materials
demonstrate
analogous
functionality
depending
on
dissociation‐recombination
reversible
bonds
with
no
need
extra
repair
agents.
However,
trade‐off
relationship
between
mechanical
strength
kinetics
in
systems,
coupled
lack
additional
functionality,
restricts
their
service
life
practical
applications.
Diversified
highly
ordered
structures
organisms
significantly
affect
energy
dissipation
mechanism,
signal
transmission
efficiency,
molecular
network
reconstruction
capability
due
multi‐dimensional
differentiated
macroscopic
composite
constructions,
microscopic
orientation
textures,
topologies/bonding
types
at
level.
These
architectures
exhibit
distinctive
strengthening
mechanisms
functionalities,
which
provide
valuable
references.
This
review
aims
providing
current
status
advanced
biomimetic
internal
micro/nanostructures.
Through
highlighting
specific
examples,
classifications,
design
inspirations,
fabrication
strategies
these
newly
developed
based
integrating
dynamic
interactions
nano/microstructures
are
outlined.
Furthermore,
balance
mechanisms,
structure–functionalization
relationships,
potential
application
values
discussed.
concludes
a
perspective
challenges,
opportunities,
prospects
development,
application,
promotion
self‐healable
bio‐like
architectures.
Cyborg and Bionic Systems,
Год журнала:
2024,
Номер
5
Опубликована: Янв. 1, 2024
With
the
prevalence
of
cardiovascular
disease,
it
is
imperative
that
medical
monitoring
and
treatment
become
more
instantaneous
comfortable
for
patients.
Recently,
wearable
implantable
optoelectronic
devices
can
be
seamlessly
integrated
into
human
body
to
enable
physiological
in
an
imperceptible
spatiotemporally
unconstrained
manner,
opening
countless
possibilities
intelligent
healthcare
paradigm.
To
achieve
biointegrated
cardiac
healthcare,
researchers
have
focused
on
novel
strategies
construction
flexible/stretchable
systems.
Here,
we
overview
progress
flexible
stretchable
optoelectronics
devices.
Firstly,
device
design
addressed,
including
mechanical
design,
interface
adhesion,
encapsulation
strategies.
Next,
practical
applications
monitoring,
optogenetics,
nongenetic
stimulation
are
presented.
Finally,
outlook
systems
discussed.
Abstract
Conductive
polymer
hydrogels
(CPHs)
are
gaining
considerable
attention
in
developing
wearable
electronics
due
to
their
unique
combination
of
high
conductivity
and
softness.
However,
the
absence
interactions,
incompatibility
between
hydrophobic
conductive
polymers
(CPs)
hydrophilic
networks
gives
rise
inadequate
bonding
CPs
hydrogel
matrices,
thereby
significantly
impairing
mechanical
electrical
properties
CPHs
constraining
utility
electronic
sensors.
Therefore,
endow
with
good
performance,
it
is
necessary
ensure
a
stable
robust
network
CPs.
Encouragingly,
recent
research
has
demonstrated
that
incorporating
supramolecular
interactions
into
enhances
interaction,
improving
overall
CPH
performance.
comprehensive
review
focusing
on
(SCPH)
for
sensing
applications
currently
lacking.
This
provides
summary
typical
strategies
employed
development
high‐performance
elucidates
SCPHs
closely
associated
Moreover,
discusses
fabrication
methods
classification
SCPH
sensors,
while
also
exploring
latest
application
scenarios
Finally,
challenges
sensors
offers
suggestions
future
advancements.
