Metallic nanoparticles unveiled: Synthesis, characterization, and their environmental, medicinal, and agricultural applications

Talanta, Год журнала: 2024, Номер 280, С. 126790 - 126790

Опубликована: Авг. 29, 2024

Язык: Английский

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Synthesis, Characterization, and Cytotoxicity Research of Sulfur-Containing Metal Complexes

Inorganics, Год журнала: 2025, Номер 13(1), С. 26 - 26

Опубликована: Янв. 17, 2025

In this experiment, the excellent coordination ability of sulfur-containing ligands was utilized. Diphenylacetyl disulfide and 3,3′-diaminodiphenyl sulfone were selected as ligands, Cu(NO3)2·3H2O, Ni(NO3)2·6H2O ZnCl2 reacted under one-pot conditions to synthesize three mononuclear complexes: [C4H18CuO12S2](I), [C12H18N4NiO11S](II) [C24H24Cl2N4O4S2Zn](III). Complex (I) belongs orthorhombic crystal system with space group Pbca, while complexes (II) (III) belong monoclinic groups P21/n P2/n. The structure complex determined using X-ray diffraction (XRD). analyzed infrared Fourier transform spectroscopy (FT-IR), ultraviolet–visible (UV–Vis), nuclear magnetic resonance (NMR), electrospray mass spectrometry (ESI-MS), thermal stability composition detected via thermogravimetry (TGA). terms application, biological activity (I)–(III) in human cancer cell lines (lung A549, liver SMMC-7721, breast MDA-MB-231, colon SW480) tested MTS method. results showed that had a good inhibitory effect on MDA-MB-231.

Язык: Английский

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Label‐free 3D cell imaging using hydrogels functionalized with switchable iridium complexes

Chemistry - A European Journal, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

The use of fluorescent labels is the most common tool to visualize cells. However, internalization dye molecules often modifies cell behavior. In this paper we demonstrate that it possible transiently label cells using a 3D scaffold, hydrogel, covalently functionalized with luminescent cyclometalated iridium(III) complexes. unique feature our design complexes are emissive only when they interact membrane while their emission quenched in water. We exploited perform real-time and staining-free visualization imaging. Iridium hydrogels very weakly immerged culture media. When added them, iridium complexes, linked gel, lipophilic "switches on" luminescence enabling clear dynamic, proliferation. A complete photophysical biological study materials presented which demonstrates potential methodology for 3D-realtime tracking.

Язык: Английский

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Chemiluminescent transition metal complexes: Mechanisms and applications

Coordination Chemistry Reviews, Год журнала: 2025, Номер 530, С. 216495 - 216495

Опубликована: Фев. 5, 2025

Язык: Английский

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Manganese(II) complexes of thiophenyl imino-ligand with synergistic behavior in biological systems, ct-DNA interactions, and catalytic oxidative performance of benzyl alcohol

Polyhedron, Год журнала: 2025, Номер unknown, С. 117441 - 117441

Опубликована: Фев. 1, 2025

Язык: Английский

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Biological and Catalytic Evaluation for Nickel (II) and Oxyvanadium (II) Chelates of tri‐Dentate Hydrazone‐Quinoxalyl Ligand

Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(3)

Опубликована: Фев. 25, 2025

ABSTRACT Formation of a tridentate mono‐basic hydrazone‐quinoxalyl ligand was done through condensation quinoxalyl‐2‐carbohydrazide with 2‐hydroxy‐1‐naphthaldehyde (H 2 dip). The coordination capability H dip Ni (II) and V (IV) ions examined at molar ratios 1:1 leading to the synthesis two distinct complexes, Ni(dip) VO(dip), respectively. chemical structure validated by many spectroscopic techniques. characterization included carbon, hydrogen, nitrogen elemental analyses assessments magnetic properties conductivity behavior. inhibited effects (organic molecules) its chelating agents on constrained proliferation three specific bacterial/fungal types, beside established human cancer cell lines, have been evaluated in relation structural impact VO(dip) compared their free research aimed determine nature influence metal chelates binding affinity dip, Ni(dip), for ct‐DNA, that is, calf thymus DNA, depending viscometric/spectrophotometric alterations characters. Furthermore, assessment constants (13.12, 15.19, 14.88 × 10 7 mol −1 dm 3 ), Gibbs energy (−40.21, −44.51, −45.01 kJ chromism modes respectively, used examine interaction mechanisms attributing increased ct‐DNA comparison dip. antioxidant potential within SOD (superoxide dismutase) DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) assays, reporting respectable reactivity. catalysts represented superior catalytic oxidative activity 1,2‐cyclooctene (unsaturated hydrocarbons, CyO) using hydrogen peroxide homogenous manner. At 80°C, yield percentage selective epoxy‐cyclooctane (CyOO) 90% after h 93% acetonitrile (the best solvent) disparity optimum actions these pertained differences electronegativity Lewis's acidity, suggested mechanistic pathway.

Язык: Английский

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Investigation of azobenzene-functionalized (2-phenylpyridine)Pt(II) complexes as switchable luminescent probes for amyloid fibrils

Polyhedron, Год журнала: 2025, Номер 269, С. 117394 - 117394

Опубликована: Янв. 8, 2025

Язык: Английский

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Ru^III–Morpholine-Derived Thiosemicarbazone-Based Metallodrugs: Lysosome-Targeted Anticancer Agents

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

The idea of coordinating biologically active ligand systems to metal centers exploit their synergistic effects has gained momentum. Therefore, in this report, three RuIII complexes 1–3 morpholine-derived thiosemicarbazone ligands have been prepared and characterized by spectroscopy HRMS along with the structure 2 through a single-crystal X-ray diffraction study. solution stability was tested using conventional techniques such as UV–vis HRMS. Further, anticancer activity HT-29 HeLa cancer cell lines. To gain insight into mechanism action, cytotoxicity, hydrophobicity, interaction DNA HSA were evaluated different methods absorption, fluorescence, circular dichroism studies. Along favorable biomolecule interaction, revealed potent selectivity toward cells, which is prerequisite for generation an drug. According viability results, 1 highest cytotoxicity among all group, against both respectively. Additionally, fluorescence-active ruthenium selectively target lysosomes, live-cell imaging. disrupt lysosome membrane potential generating excessive amount reactive oxygen species, results apoptotic mode death.

Язык: Английский

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Leveraging Metal Complexes for Microsecond Lifetime-Based Chloride Sensing

ACS Sensors, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Chloride is the most abundant anion in cells and plays many critical roles maintaining cellular homeostasis. However, current chloride indicators are rare with inherent sensitivity their emission properties, such as vulnerability to pH changes or short lifetimes. These limitations restrict application aqueous media imaging. In this work, we employed a transition-metal complex bearing pyridinium recognition unit for studied phosphorescence properties. Iridium(III) 1 was synthesized an alternative chloride-sensitive luminophore. The conjugable design also allows customization desired applications. Complex exhibited high selectivity sensing across different physiological environments, regardless of fluctuation ionic strength. Additionally, featured microsecond lifetime. ability can be measured through both luminescence intensity long-lived phosphorescent lifetime, providing potential route analogue 1b successfully applied imaging Cl- environments showed dose-dependent responses live fixed cells.

Язык: Английский

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Visible to near-infrared light activated photoacids: Molecular architecture for chemical and biological applications

Journal of Organometallic Chemistry, Год журнала: 2025, Номер 1027, С. 123525 - 123525

Опубликована: Янв. 18, 2025

Язык: Английский

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