Enantio- and Diastereoselective Synthesis of P-Stereogenic Phospholane Oxides via Cobalt-Catalyzed Hydroalkylation DOI
Dao‐Yong Zhu, Yating Zhang,

Fu Cheng

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Chiral phospholane ligands and catalysts have been widely applied in asymmetric catalysis synthesis. However, the construction of chiral skeleton remains challenging primarily relies on use auxiliaries or resolution. In this work, a highly enantioselective diastereoselective synthesis P-stereogenic oxides has achieved through cobalt-catalyzed desymmetric hydroalkylation strategy. This method enables two discrete stereocenters with excellent yields enantiomeric excesses.

Язык: Английский

Electrifying P(V): Access to Polar and Radical Reactivity DOI Open Access

Mahdi Jafarzadeh,

Molhm Nassir, Luca Gherardi

и другие.

Angewandte Chemie International Edition, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Abstract Electrochemical, fully stereoselective P(V)‐radical hydrophosphorylation of olefins and carbonyl compounds using a P(V) reagent is disclosed. By strategically selecting the anode material, radical reactivity accessible for alkene whereas polar pathway operates ketone hydrophosphorylation. The mechanistic intricacies these chemoselective transformations were explored in‐depth.

Язык: Английский

Процитировано

1
Tropos Diphenylmethane-Based Phosphine–Phosphoramidite Ligands: Design, Synthesis, and Application in Catalytic Asymmetric Hydrogenation DOI
Zhong Zheng, Zheng‐Chao Duan, Xiang‐Ping Hu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

A series of chiral hybrid diphosphorus ligands incorporating a conformationally flexible tropos diphenylmethane-based phosphoramidite unit have been developed and evaluated in the Rh-catalyzed asymmetric hydrogenation 2-(1-arylvinyl)anilides α-enamides, leading to up >99% yield 99% enantiomeric excess. Preliminary results from comparative studies showcased extraordinary catalytic performance these phosphine–phosphoramidite ligands, with competency essentially superior those well-established regular rigid backbone.

Язык: Английский

Процитировано

1
MAdPHOS, a P-Stereogenic Aminodiphosphane Ligand with Adamantyl Groups: Synthesis, NH/PH Tautomerism, and Rhodium and Nickel Complexes DOI
Marina Bellido,

Helena Solé-Àvila,

Martí Sidro

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

A novel chiral ligand, named MAdPHOS, bearing a P-stereogenic phosphane and diadamantyl linked by NH bridge has been synthesized. This bulky, C1-symmetric, PNP ligand prepared from enantiopure tert-butylmethyl aminophosphane was obtained as crystalline solid. The NH/PH tautomerism, air-stability, σ-donor capacity of MAdPHOS have assessed herein. free prepared, showing much higher stability, in the solid form, than its tert-butyl analogue MaxPHOS. Both rhodium nickel COD complexes prepared. Rh-MAdPHOS complex shown outstanding enantioselectivities asymmetric hydrogenation enamides.

Язык: Английский

Процитировано

1
Kinetic Resolution of α,β-Unsaturated Tertiary Phosphine Oxides via Alkene E → Z Isomerization Catalyzed by a Photoexcited Chiral Copper Complex DOI
Liang Liu,

Shiqi Ren,

Xiaohong Gu

и другие.

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 4541 - 4549

Опубликована: Март 3, 2025

Язык: Английский

Процитировано

1
Ru-Catalyzed Asymmetric Hydrogenation of α,β-Unsaturated γ-Lactams DOI

Zheng‐Dong Ding,

Yicong Luo, Qianjia Yuan

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(36), С. 25312 - 25320

Опубликована: Сен. 2, 2024

A highly efficient Ru-catalyzed asymmetric hydrogenation of α,β-unsaturated γ-lactams has been developed by using a

Язык: Английский

Процитировано

6
Chiral Polymeric Diamine Ligands for Iridium-Catalyzed Asymmetric Transfer Hydrogenation DOI Creative Commons
Yaodong Lin,

Guangqing Xu,

Wenjun Tang

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер unknown

Опубликована: Сен. 25, 2024

A series of polymeric chiral diamine ligands are developed by diboron-templated asymmetric reductive couplings, and their iridium complexes Ir-polydiamines efficient recyclable catalysts for transfer hydrogenation (ATH) functionalized ketones, affording a optically active secondary alcohols in excellent enantioselectivities (up to 99% ee) unprecedentedly high total TONs (12,000, six cycles). Ir-polydiamine with longer chains offered higher reactivities, providing plausible deactivation mechanism practical solutions ATH vitamin B5 phenylephrine.

Язык: Английский

Процитировано

4
Dual Doping with Nitrogen and Rare Earth Metals for Tailored Photoluminescence and Antimicrobial Properties in Hydrothermally Synthesized Carbon Dots DOI
Amir Said,

Mohamed Mohamady Ghobashy,

Gharieb S. El‐Sayyad

и другие.

Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 105752 - 105752

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Manganese(I)-Catalyzed Enantioselective Alkylation To Access P-Stereogenic Phosphines DOI Creative Commons
Baonian Wan, Marta Castiñeira Reis, Tizian‐Frank Ramspoth

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

This work introduces a novel Mn(I)-catalyzed enantioselective alkylation methodology that efficiently produces wide array of P-chiral phosphines with outstanding yields and enantioselectivities. Notably, the exceptional reactivity Mn(I) complexes in these reactions is demonstrated by their effective catalysis both typically reactive alkyl iodides bromides, as well less chlorides. approach broadens accessibility to various simplifies synthesis chiral tridentate pincer concise 1–2 step process, contrary conventional, labor-intensive multistep procedures. Importantly, development significantly expands applicability earth-abundant Mn(I)-based beyond recently established roles catalytic hydrogenative conjugate addition reactions, emphasizing potential viable alternative noble metal chemistry and, some cases, even surpassing performance.

Язык: Английский

Процитировано

0
Connecting the Complexity of Stereoselective Synthesis to the Evolution of Predictive Tools DOI Creative Commons
Jiajing Li, Jolene P. Reid

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review provides an overview of predictive tools in asymmetric synthesis. The evolution methods from simple qualitative pictures to complicated quantitative approaches is connected with the increased complexity stereoselective

Язык: Английский

Процитировано

0
An Aziridine and a 2‐Pyrrolidone with Pyridyl Sidearms as Ligands for Cationic Rh(I)‐Catalyzed Hydrosilylation and Hydrogenation of C=C and C≡C Bonds. DOI Open Access

Sudip Baguli,

Samarshi Chakraborty,

Soumajit Nath

и другие.

Chemistry - A European Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Phosphine- or carbene-based soft ligands are customarily used in Rh and other late transition metal catalyzed alkene alkyne hydrosilylation hydrogenation. We report here an aziridine a 2-pyrrolidone with pyridyl sidearms, whose cationic Rh(I) complexes prove as excellent catalysts for hydrosilylating terminal olefins by Et3SiH giving anti-Markovnikov products selectively. To the best of our knowledge, [(2-pyrrolidone)-Rh]+ seems to be most active catalyst recording highest TOF 24000 h-1. It works remarkably (TOF: 714 h-1) even at 10 ppm concentration! Terminal alkynes hydrosilylated too give β-(Z)-vinylsilanes Both also hydrogenate alkenes doubly-hydrogenate alkynes, both internal, under ambient benchtop conditions. But hydrogenation, [(aziridine)-Rh]+ better. air-stable.

Язык: Английский

Процитировано

0