Acta Crystallographica Section E Crystallographic Communications,
Год журнала:
2024,
Номер
80(10), С. 1044 - 1048
Опубликована: Сен. 24, 2024
In
the
racemic
title
compound,
C
28
H
30
O
2
,
naphthyl
ring
systems
subtend
a
dihedral
angle
of
68.59
(1)°
and
molecular
conformation
is
consolidated
by
pair
intramolecular
C—H...π
contacts.
The
crystal
packing
features
weak
contact
van
der
Waals
forces.
A
Hirshfeld
surface
analysis
structure
reveals
that
most
significant
contributions
are
from
H...H
(73.2%)
C...H/H...C
(21.2%)
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 25, 2025
Cryptochiral
compounds
are
indispensable
in
biology
systems
and
medical
applications,
yet
the
development
of
high-performance
detection
method
remains
challenging.
Here,
we
report
a
hinge-like
dinuclear
Pt(II)
complex
as
stereodynamic
probe
for
cryptochirality
sensing.
This
features
constrained,
closed
conformation
achieved
through
synergistic
intramolecular
π
−
stacking
metal-metal
interactions
between
cyclometalated
wings.
The
shows
robust
chiroptical
response
to
center-to-axial
chiral
induction
during
rapid
condensation
with
cryptochiral
that
adopts
more
energetically
favorable
conformation.
resulting
intense
Cotton
effects
at
long
wavelengths
enable
in-situ
circular
dichroism
analysis
determinate
absolute
configuration
enantiometric
composition
molecules.
Furthermore,
near-infrared
phosphorescence
characteristics
hinge
have
been
explored
develop
it
an
optical
sensor
accurate
quantification
With
its
dual
CD
capabilities,
this
great
potential
high-throughput
screening
analysis.
authors
complexes
probes
Abstract
The
current
manuscript
discusses
the
density
functional
based
ab
initio
investigations
of
[3,3]
oxa‐Claisen
rearrangement
reactions
involving
functionalized
1‐formyl‐2‐vinyl
cyclobutane/lactam,
emphasizing
their
expected
transformations
into
various
8
membered
heterocycles.
most
feasible
molecular
assembly
for
targeted
cyclobutane/lactam
has
been
identified.
Reaction
parameters,
including
reaction
and
activation
energies,
have
calculated
compared.
theoretical
effect
substituents
(H,
Ph,
SO
2
Ph)
at
different
positions
tethered
4‐vinyl
3‐oxa
functionalities
cyclobutane/lactams
also
studied
proposed
carba‐Claisen
cyclobutane/lactam.
Our
findings
suggest
an
energy
barrier
ranging
from
50
to
100
kcal/mol
rearrangements.
We
observed
a
reduction
in
20
52
with
polar
solvent,
whereas
decrease
30
was
noted
nonpolar
solvent.
Claisen
2‐vinyl
carba‐aldehydes
demonstrates
exothermic
reaction.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(49), С. 19632 - 19640
Опубликована: Ноя. 27, 2024
To
address
the
challenge
of
chiral
recognition
in
terms
efficiency
and
generality,
we
propose
a
novel
fluorescence
sensing
approach
by
rationally
designing
metal-ion-responsive
molecular
tweezers.
The
flexible
adaptable
tweezers
enable
facile
31
structurally
varied
primary
amine
compounds,
including
amino
acids,
acid
esters,
amines.
Notably,
upon
stimulation
zinc
ions,
demonstrate
higher
enantioselective
response.
Combined
density
functional
theory
calculations
reveal
that
mechanism
relies
on
differential
reaction
rates
potential
hydrogen-bonding
interactions
between
two
enantiomers
receptor,
which
results
one
forming
more
abundant,
stable,
rigid
complex
with
resulting
significant
increase
intensity
enantioselectivity.
stimuli-responsive
provides
strategy
for
precise
stereocontrol
universality
recognition,
offering
promising
tool
applications
various
fields.
Symmetry,
Год журнала:
2025,
Номер
17(2), С. 293 - 293
Опубликована: Фев. 14, 2025
The
analysis
of
natural
and
artificial
chiral
compounds
is
vital
wherever
the
nuances
in
three-dimensional
structure
are
decisive
for
possibility
their
further
use,
e.g.,
as
pharmaceuticals
or
catalysts.
qualitative
determination
a
entity
requires
either
an
anomalous
scattering
X-ray
radiation
chiroptical
techniques,
which
electronic
circular
dichroism
(ECD)
one
most
useful.
Chiroptical
sensing
that
uses
stereodynamic
probes
remains
remedies
problem
lack
suitable
chromophore
molecules
compound.
A
covalent
non-covalent
binding
ECD-silent
molecule
(the
inducer)
to
UV-active
chromophoric
system
(chiroptical
probe)
led
obtaining
complex
ECD
active
at
given
spectral
region.
transfer
structural
information
from
permanently
inducer
structurally
labile
probe
results
adjusting
latter’s
environment.
This
contribution
focuses
on
some
fundamental
aspects
chirality
using
conformationally
probes.
It
discusses
mechanism
action
arbitrarily
chosen
sensors,
with
particular
emphasis
based
di-
triarylmethyl
derivatives
biphenyl
its
congeners.
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 25, 2025
Abstract
Absolute
helix‐sense‐selective
polymerization
of
an
achiral
acetylene
monomer
(
1
)
in
one‐handed
helical
channels
created
with
decomposition
(±)‐poly
using
circularly
polarized
light
is
realized
no
chiral
compounds.
In
addition,
the
relative
optical
yield
(%ee)
formed
oligomers
controlled
by
those
channels.
Chemical Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Axially
chiral
substrates
were
transformed
into
enantiomer-enriched
π-extended
helicenes
via
a
chiral-transfer-based
Scholl
reaction,
and
enantiomers
efficiently
separated
without
labor-intensive
high-performance
liquid
chromatography
(HPLC).
The Chemical Record,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 29, 2025
Abstract
Carbazoles
are
an
important
class
of
nitrogen‐containing
heterocycles
found
in
diverse
natural
products,
bioactive
molecules,
and
functional
materials.
Their
broader
applications
have
driven
extensive
research
into
their
synthesis
functionalization.
Among
various
approaches,
transition
metal‐catalyzed
C−H
activation
has
emerged
as
a
powerful
tool
for
direct
functionalization,
offering
regioselectivity,
efficiency,
sustainability.
This
review
comprehensively
summarizes
advancements
functionalization
carbazoles.
Various
catalytic
systems
employing
palladium,
ruthenium,
rhodium,
nickel,
cobalt,
copper,
iron
enabled
alkylation,
alkenylation,
acylation,
arylation,
alkynylation,
heteroatom
incorporation
These
methodologies
late‐stage
diversification
opened
avenues
accessing
structurally
complex
carbazole
derivatives
with
tailored
properties.
The
aims
to
provide
comprehensive
guide
researchers
exploring
via
activation,
highlighting
key
mechanistic
insights,
scope,
emerging
trends
this
field.
RSC Advances,
Год журнала:
2025,
Номер
15(19), С. 14881 - 14892
Опубликована: Янв. 1, 2025
Biaryls
exhibiting
axial
chirality
have
been
extensively
exploited
in
fields
such
as
asymmetric
catalysis,
but
the
biaryl
linkage
typically
consists
of
benzenoid
aromatic
rings,
with
non-benzenoid
biaryls
being
scarce.
Here
we
report
first
preparation
a
(non-benzenoid)
1,1'-biazulene-2,2'-diol
("1,1'-BAzOL")
enantiopure
form
and
determine
its
barrier
to
racemisation.
Furthermore
transformed
into
corresponding
2,2'-bis(phosphonate),
thereby
demonstrating
functional
group
interconversion
through
cross
coupling
highlighting
potential
for
diversification.
