3d Transition Metals for C–H Activation

Chemical Reviews, Год журнала: 2018, Номер 119(4), С. 2192 - 2452

Опубликована: Ноя. 27, 2018

C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with notable applications to material crop protection, drug discovery, and pharmaceutical industries, among others. Despite major advances, the vast majority of these functionalizations required precious 4d or 5d transition metal catalysts. Given cost-effective sustainable nature earth-abundant first row metals, development less toxic, inexpensive 3d catalysts gained considerable recent momentum a significantly more environmentally-benign economically-attractive alternative. Herein, we provide comprehensive overview on until summer 2018.

Язык: Английский

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A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry

Chemical Society Reviews, Год журнала: 2018, Номер 47(17), С. 6603 - 6743

Опубликована: Янв. 1, 2018

The present review is devoted to summarizing the recent advances (2015-2017) in field of metal-catalysed group-directed C-H functionalisation. In order clearly showcase molecular diversity that can now be accessed by means directed functionalisation, whole organized following directing groups installed on a substrate. Its aim comprehensive reference work, where specific group easily found, together with transformations which have been carried out it. Hence, primary format this schemes accompanied concise explanatory text, are ordered sections according their chemical structure. feature typical substrates used, products obtained as well required reaction conditions. Importantly, each example commented respect most important positive features and drawbacks, aspects such selectivity, substrate scope, conditions, removal, greenness. targeted readership both experts functionalisation chemistry (to provide overview progress made last years) and, even more so, all organic chemists who want introduce way thinking for design straightforward, efficient step-economic synthetic routes towards molecules interest them. Accordingly, should particular also scientists from industrial R&D sector. overall goal promote application reactions outside research dedicated method development establishing it valuable archetype contemporary R&D, comparable role cross-coupling play date.

Язык: Английский

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C–H activation

Nature Reviews Methods Primers, Год журнала: 2021, Номер 1(1)

Опубликована: Июнь 17, 2021

Язык: Английский

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Toolbox for Distal C–H Bond Functionalizations in Organic Molecules

Chemical Reviews, Год журнала: 2021, Номер 122(6), С. 5682 - 5841

Опубликована: Окт. 18, 2021

Transition-metal-catalyzed C–H activation has developed a contemporary approach to the omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted take help this methodology plan their synthetic discourses. This paradigm shift helped in development industrial units as well, making synthesis natural products and pharmaceutical drugs step-economical. In vast zone bond activation, functionalization proximal bonds gained utmost popularity. Unlike bonds, distal is more strenuous requires distinctly specialized techniques. review, we compiled various methods adopted functionalize mechanistic insights within each these procedures, scope methodology. With give complete overview expeditious progress made field organic chemistry while also highlighting its pitfalls, thus leaving open for further modifications.

Язык: Английский

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Electrochemical Cobalt-Catalyzed C–H Oxygenation at Room Temperature

Journal of the American Chemical Society, Год журнала: 2017, Номер 139(51), С. 18452 - 18455

Опубликована: Ноя. 18, 2017

Electrochemical cobalt-catalyzed C–H functionalizations were achieved in terms of oxygenation under mild conditions at 23 °C. The robust electrochemical functionalization was characterized by ample substrate scope, whereas mechanistic studies provided support for a facile cleavage. proved viable on arenes and alkenes with excellent levels positional diastereo-selectivity, avoiding the use stoichiometric silver(I) oxidants ambient conditions.

Язык: Английский

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Introduction: CH Activation

Chemical Reviews, Год журнала: 2017, Номер 117(13), С. 8481 - 8482

Опубликована: Июль 12, 2017

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTIntroduction: CH ActivationRobert H. Crabtree and Aiwen LeiView Author Information Yale University Wuhan UniversityCite this: Chem. Rev. 2017, 117, 13, 8481–8482Publication Date (Web):July 12, 2017Publication History Published online12 July 2017Published inissue 12 2017https://pubs.acs.org/doi/10.1021/acs.chemrev.7b00307https://doi.org/10.1021/acs.chemrev.7b00307editorialACS PublicationsCopyright © 2017 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions free to access through this site. Learn MoreArticle Views39442Altmetric-Citations261LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail (2 MB) Get e-AlertscloseSUBJECTS:Alcohols,Functionalization,Hydrocarbons,Metals,Palladium e-Alerts

Язык: Английский

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Transition-metal mediated carbon–sulfur bond activation and transformations: an update

Chemical Society Reviews, Год журнала: 2020, Номер 49(13), С. 4307 - 4359

Опубликована: Янв. 1, 2020

This review summarizes the advances in transition-metal-catalyzed cross-couplingviacarbon–sulfur bond activation and cleavage since late 2012 as an update of critical published early 2013 (Chem. Soc. Rev., 2013,42, 599–621).

Язык: Английский

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Enantioselective C(sp³)–H Amidation of Thioamides Catalyzed by a Cobalt^III/Chiral Carboxylic Acid Hybrid System

Angewandte Chemie International Edition, Год журнала: 2018, Номер 58(4), С. 1153 - 1157

Опубликована: Ноя. 27, 2018

Abstract Recent advances in Cp x M III catalysis (M=Co, Rh, Ir) have enabled a variety of enantioselective C(sp 2 )−H functionalization reactions, but 3 is still largely unexplored. We describe an asymmetric amidation thioamides using achiral Co /chiral carboxylic acid hybrid catalytic system, which provides easy and straightforward access to chiral β‐amino thiocarbonyl carbonyl building blocks with quaternary carbon stereocenter.

Язык: Английский

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Electrochemical C−H Amination by Cobalt Catalysis in a Renewable Solvent

Angewandte Chemie International Edition, Год журнала: 2018, Номер 57(18), С. 5090 - 5094

Опубликована: Март 6, 2018

Syntheses of substituted anilines primarily rely on palladium-catalyzed coupling chemistry with prefunctionalized aryl electrophiles. While oxidative aminations have emerged as powerful alternatives, they largely produce undesired metal-containing by-products in stoichiometric quantities. In contrast, described herein is the unprecedented electrochemical C-H amination by cobalt-catalyzed activation. The environmentally benign electrocatalysis avoids metal oxidants, can be conducted under ambient air, and employs a biomass-derived, renewable solvent for sustainable an atom- step-economical manner H2 sole byproduct.

Язык: Английский

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Electrochemical C−H/N−H Activation by Water‐Tolerant Cobalt Catalysis at Room Temperature

Angewandte Chemie International Edition, Год журнала: 2018, Номер 57(9), С. 2383 - 2387

Опубликована: Янв. 10, 2018

Electrochemistry enabled C-H/N-H functionalizations at room temperature by external oxidant-free cobalt catalysis. Thus, the sustainable electrocatalysis manifold proceeds with excellent levels of chemoselectivity and positional selectivity, ample scope, thus allowing electrochemical C-H activation under exceedingly mild reaction conditions in water.

Язык: Английский

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