Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
62(1)
Опубликована: Ноя. 8, 2022
Despite
the
advances
in
area
of
catalytic
alkene
hydrosilylation,
enantioselective
hydrosilylation
alkenes
bearing
a
heteroatom
substituent
is
scarce.
Here
we
report
rhodium-catalyzed
β,β-disubstituted
enamides
to
directly
afford
valuable
α-aminosilanes
highly
regio-,
diastereo-,
and
manner.
Stereodivergent
synthesis
could
be
achieved
by
regulating
substrate
geometry
ligand
configuration
generate
all
possible
stereoisomers
high
enantio-purity.
Molecules,
Год журнала:
2019,
Номер
24(4), С. 791 - 791
Опубликована: Фев. 22, 2019
Many
naturally
occurring
xanthones
are
chiral
and
present
a
wide
range
of
biological
pharmacological
activities.
Some
them
have
been
exhaustively
studied
subsequently,
obtained
by
synthesis.
In
order
to
obtain
libraries
compounds
for
structure
activity
relationship
(SAR)
studies
as
well
improve
the
activity,
new
bioactive
analogues
derivatives
inspired
in
natural
prototypes
were
synthetized.
Bioactive
compromise
large
structural
multiplicity
compounds,
including
diversity
derivatives.
Thus,
recently
an
exponential
interest
synthetic
(CDXs)
has
witnessed.
The
methodologies
can
afford
structures
that
otherwise
could
not
be
reached
within
products
SAR
studies.
Another
reason
justifies
this
trend
is
both
enantiomers
using
appropriate
pathways,
allowing
possibility
perform
enantioselectivity
work,
literature
review
CDXs
presented.
structures,
approaches
used
their
synthesis
activities
described,
emphasizing
The Journal of Organic Chemistry,
Год журнала:
2020,
Номер
85(21), С. 13391 - 13414
Опубликована: Окт. 20, 2020
Due
to
their
inherent
ring
strain
and
electrophilicity,
epoxides
are
highly
attractive
building
blocks
for
fundamental
organic
reactions.
However,
controlling
the
regioselectivity
of
disubstituted
epoxide
transformations
is
often
particularly
challenging.
Most
Lewis
acid-mediated
processes
take
advantage
intrinsic
steric
or
electronic
substrate
bias
influence
site
nucleophilic
attack.
Therefore,
scope
many
these
systems
frequently
quite
limited.
Recent
efforts
generate
catalysts
that
can
overcome
have
expanded
synthetic
utility
well-known
In
this
Perspective,
we
highlight
various
regioselective
epoxides,
emphasizing
those
inspired
production
challenging,
catalyst-controlled
processes.
Angewandte Chemie International Edition,
Год журнала:
2021,
Номер
60(50), С. 26368 - 26372
Опубликована: Окт. 8, 2021
A
regio-
and
diastereoselective
copper-catalyzed
carbomagnesiation
of
1,2-dialkylated
cyclopropenes
is
reported.
The
regioselectivity
controlled
by
a
subtle
tethered
Lewis
basic
moiety.
chelating
moieties
allow
the
differentiation
between
two
electronically
tantamount
organometallic
intermediates.
Further
functionalization
grants
access
to
polysubstituted
stereodefined
cyclopropanes
bearing
up
five
alkyl
groups.
Advanced Synthesis & Catalysis,
Год журнала:
2021,
Номер
363(19), С. 4627 - 4631
Опубликована: Июль 30, 2021
Abstract
This
paper
reports
the
transition
metal‐free
C(
sp
3
)−H
sulfenylation
of
arylacetamides
by
using
thiophenols
as
sulfenyl
reagents.
The
reactions
take
place
in
presence
only
K
PO
4
.
Control
experiments
indicate
that
proceed
via
a
featured
sulfur‐centred
free
radical
intermediate.
In
addition,
synthesis
2‐thiomethyl
benzoxazoles
has
been
realized
p
‐toluenesulfonic
acid
(
‐TSA)
promoted
annulation
sulfenylated
products.
magnified
image
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
62(1)
Опубликована: Ноя. 8, 2022
Despite
the
advances
in
area
of
catalytic
alkene
hydrosilylation,
enantioselective
hydrosilylation
alkenes
bearing
a
heteroatom
substituent
is
scarce.
Here
we
report
rhodium-catalyzed
β,β-disubstituted
enamides
to
directly
afford
valuable
α-aminosilanes
highly
regio-,
diastereo-,
and
manner.
Stereodivergent
synthesis
could
be
achieved
by
regulating
substrate
geometry
ligand
configuration
generate
all
possible
stereoisomers
high
enantio-purity.
