Green Chemistry,
Год журнала:
2021,
Номер
23(2), С. 1041 - 1049
Опубликована: Янв. 1, 2021
A
copper
modified
phosphorus
doped
g-C3N4
(Cu/P-CN)
has
been
prepared
and
identified
as
an
efficient
catalyst
for
the
synthesis
of
N-arylpyridin-2-amine
derivatives
by
reaction
2-aminopyridine
aryl
boronic
acid
under
irradiation
blue
light.
Advanced Synthesis & Catalysis,
Год журнала:
2020,
Номер
362(16), С. 3311 - 3331
Опубликована: Июнь 12, 2020
Abstract
Chan‐Lam
reactions
hold
promise
as
one
of
the
most
efficient
synthetic
methods
to
construct
various
carbon‐heteroatom
or
carbon‐carbon
bonds.
Recently,
a
series
were
developed
boost
organic
synthesis.
Herein,
we
summarized
latest
research
and
progress
coupling
illustrate
its
value.
magnified
image
Molecules,
Год журнала:
2020,
Номер
25(15), С. 3493 - 3493
Опубликована: Июль 31, 2020
Cross-coupling
reactions
have
played
a
critical
role
enabling
the
rapid
expansion
of
structure–activity
relationships
(SAR)
during
drug
discovery
phase
to
identify
clinical
candidate
and
facilitate
subsequent
development
processes.
The
reliability
flexibility
this
methodology
attracted
great
interest
in
pharmaceutical
industry,
becoming
one
most
used
approaches
from
Lead
Generation
Optimization.
In
mini-review,
we
present
an
overview
cross-coupling
reaction
applications
medicinal
chemistry
efforts,
particular
Suzuki–Miyaura
Buchwald–Hartwig
as
remarkable
resource
for
generation
carbon–carbon
carbon–heteroatom
bonds.
To
further
appreciate
impact
methodology,
authors
discuss
some
recent
examples
candidates
that
utilize
key
their
large-scale
synthetic
process.
Looking
into
future
opportunities,
highlight
versatility
towards
new
chemical
modalities
like
DNA-encoded
libraries
(DELs),
peptides
cyclopeptides,
allosteric
modulators,
proteolysis
targeting
chimera
(PROTAC)
approaches.
ACS Catalysis,
Год журнала:
2020,
Номер
10(8), С. 4751 - 4769
Опубликована: Март 30, 2020
Dioxazolones
are
a
convenient
class
of
acyl
nitrene
transfer
reagents.
Their
application
in
homogeneous
transition-metal
catalysis
has
led
to
many
new
amidation
reactions.
typically
activated
by
transition
metals
at
relatively
low
reaction
temperatures.
The
metal
nitrenoids
formed
decarboxylative
activation
dioxazolones
generally
electron
deficient
and
commonly
react
concerted
fashion.
"Intermolecular"
insertion
reactions
involving
preactivated
C–H
bonds
("inner-sphere"
mechanism)
easily
compete
with
the
Curtius-type
rearrangement,
but
for
intramolecular
"direct"
transfer/insertion
nonpreactivated
substrates
(i.e.,
without
preceding
formation
metal–carbon
or
metal–hydride
bonds)
extensive
ligand
optimization
is
important
prevent
such
unwanted
side
ease
dioxazolone
synthesis,
CO2
gas
as
sole
byproduct
from
dioxazolones,
importance
general
development
several
interesting
producing
N-aryl
amides,
oxazoles,
lactams.
Since
proceeds
under
mild
conditions,
stereo-
enantioselective
also
possible,
which
useful
synthesis
bioactive
nitrogen-containing
compounds.
This
review
provides
an
overview
these
reported
recent
years.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(14), С. 6163 - 6172
Опубликована: Апрель 4, 2022
We
report
a
copper-catalyzed
strategy
for
arylboronic
ester
synthesis
that
exploits
photoinduced
ligand-to-metal
charge
transfer
(LMCT)
to
convert
(hetero)aryl
acids
into
aryl
radicals
amenable
ambient-temperature
borylation.
This
near-UV
process
occurs
under
mild
conditions,
requires
no
prefunctionalization
of
the
native
acid,
and
operates
broadly
across
diverse
aryl,
heteroaryl,
pharmaceutical
substrates.
also
one-pot
procedure
decarboxylative
cross-coupling
merges
catalytic
LMCT
borylation
palladium-catalyzed
Suzuki-Miyaura
arylation,
vinylation,
or
alkylation
with
organobromides
access
range
value-added
products.
The
utility
these
protocols
is
highlighted
through
development
heteroselective
double-decarboxylative
C(sp2)-C(sp2)
coupling
sequence,
pairing
halogenation
processes
two
distinct
(including
substrates)
subsequent
cross-coupling.
Science,
Год журнала:
2023,
Номер
382(6667), С. 191 - 197
Опубликована: Окт. 12, 2023
Second-
and
third-row
transition
metal
complexes
are
widely
employed
in
photocatalysis,
whereas
earth-abundant
first-row
metals
have
found
only
limited
use
because
of
the
prohibitively
fast
decay
their
excited
states.
We
report
an
unforeseen
reactivity
mode
for
productive
photocatalysis
that
uses
cobalt
polypyridyl
as
photocatalysts
by
exploiting
Marcus
inverted
region
behavior
couples
increases
excited-state
energies
with
increased
lifetimes.
These
(III)
can
engage
bimolecular
virtue
strong
redox
potentials
sufficiently
long
lifetimes,
catalyzing
oxidative
C(sp2)-N
coupling
aryl
amides
challenging
sterically
hindered
boronic
acids.
More
generally,
results
imply
chromophores
be
designed
to
increase
lifetimes
while
simultaneously
increasing
energies,
providing
a
pathway
relatively
abundant
photoredox
catalysts.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(4), С. 1986 - 1992
Опубликована: Янв. 21, 2022
We
report
here
a
mechanistically
distinct
approach
to
achieve
Suzuki-Miyaura-type
cross-couplings
between
alkyl
iodides
and
aryl
organoborons.
This
process
requires
copper
catalyst
but,
in
contrast
with
previous
approaches
based
on
palladium
nickel
systems,
does
not
utilizes
the
metal
for
activation
of
electrophile.
Instead,
this
strategy
exploits
halogen-atom-transfer
ability
α-aminoalkyl
radicals
convert
secondary
into
corresponding
that
then
are
coupled
aryl,
vinyl,
alkynyl,
benzyl,
allyl
boronate
species.
These
novel
coupling
reactions
feature
simple
setup
conditions
(1
h
at
room
temperature)
facilitate
access
privileged
motifs
targeted
by
pharmaceutical
sector.
