Why Western Mosquitofish (Gambusia affinis) Is Tolerant to Se Contamination: Complex Mechanistic Explanations DOI

Xinrong Wei,

Xiao Li,

Wenji Zhou

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

The western mosquitofish (Gambusia affinis (G. affinis)) is often the only fish that survives in various selenium-contaminated aquatic environments. However, mechanisms of its survival such environments remain seldom explored. In this study, acute toxicity selenomethionine (Se-Met) a variety species (four oviparous and four ovoviviparous species) was evaluated, followed by chronic effects Se-Met on G. zebrafish (Danio rerio (D. rerio)), focusing Se accumulation gonads offspring, reproductive biology, offspring development. Our results showed LC50-96h largest among eight fish, confirming elevated resistance to Se. Meanwhile, transcripts genes related selenoproteins sulfoproteins opposite responses between D. exposure, along with altered levels total but not fish. exposures gonads, gonadal development embryonic early larval development, efflux embryos larvae were apparently different rerio. Finally, differentially expressed (particularly antioxidant inflammation) mostly stimulated inhibited This study has demonstrated capacity metabolism physiology can help partially explain Se-contaminated ecosystems.

Язык: Английский

Effects of Broflanilide on Oxidative Stress and Expression of Apoptotic Genes in Zebrafish (Danio rerio) Gill DOI
Kai Wang,

Wunan Che,

Manman Duan

и другие.

Bulletin of Environmental Contamination and Toxicology, Год журнала: 2023, Номер 110(5)

Опубликована: Май 1, 2023

Язык: Английский

Процитировано

9
Malnutrition exacerbating neuropsychiatric symptoms on the Alzheimer's continuum is relevant to the cAMP signaling pathway: Human and mouse studies DOI Creative Commons
Jiwei Jiang, Tianlin Jiang,

Xiaohong Wang

и другие.

Alzheimer s & Dementia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Abstract INTRODUCTION Malnutrition correlates with neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD); however, the potential mechanism underlying this association remains unclear. METHODS Baseline and longitudinal associations of nutritional status NPSs were analyzed 374 patients on AD continuum 61 healthy controls. Serum biomarkers, behavioral tests, cerebral neurotransmitters, differentially gene expression evaluated standard malnourished diet–fed transgenic APPswe/PSEN1dE9 (APP/PS1) mice. RESULTS Poor increased blood flow midbrain striatum associated severe general subtypes, especially depression, anxiety, apathy. APP/PS1 mice fed a diet showed poor status, depression‐ anxiety‐like behaviors, altered neurotransmitter levels, downregulated c‐Fos striatum; these suppressed cyclic adenosine monophosphate (cAMP) signaling pathway. DISCUSSION exacerbating is relevant to cAMP pathway striatum, suggesting for targeted interventions mitigate continuum. Highlights linked specific symptom (NPS) deterioration. affects NPSs, usually involving striatum. Malnourished induces behaviors exacerbates

Язык: Английский

Процитировано

0
Low light intensity dysregulated growth and behavior of juvenile rainbow trout (Oncorhynchus mykiss) via microbiota-gut-brain axis DOI
Xin Hu,

Zheng-Xiang Zhang,

Meng-Zhi Qian

и другие.

Aquaculture, Год журнала: 2025, Номер unknown, С. 742388 - 742388

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Metabolomic and molecular analysis reveals multiple pathways of TBBPA-induced developmental toxicity in zebrafish embryos DOI
Qian Xu,

Ruixi Gan,

Qing Wang

и другие.

Toxicology and Applied Pharmacology, Год журнала: 2025, Номер unknown, С. 117295 - 117295

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Why Western Mosquitofish (Gambusia affinis) Is Tolerant to Se Contamination: Complex Mechanistic Explanations DOI

Xinrong Wei,

Xiao Li,

Wenji Zhou

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

The western mosquitofish (Gambusia affinis (G. affinis)) is often the only fish that survives in various selenium-contaminated aquatic environments. However, mechanisms of its survival such environments remain seldom explored. In this study, acute toxicity selenomethionine (Se-Met) a variety species (four oviparous and four ovoviviparous species) was evaluated, followed by chronic effects Se-Met on G. zebrafish (Danio rerio (D. rerio)), focusing Se accumulation gonads offspring, reproductive biology, offspring development. Our results showed LC50-96h largest among eight fish, confirming elevated resistance to Se. Meanwhile, transcripts genes related selenoproteins sulfoproteins opposite responses between D. exposure, along with altered levels total but not fish. exposures gonads, gonadal development embryonic early larval development, efflux embryos larvae were apparently different rerio. Finally, differentially expressed (particularly antioxidant inflammation) mostly stimulated inhibited This study has demonstrated capacity metabolism physiology can help partially explain Se-contaminated ecosystems.

Язык: Английский

Процитировано

0