The complexation of atmospheric Brown carbon surrogates on the generation of hydroxyl radical from transition metals in simulated lung fluid DOI Creative Commons
Yan Lyu, Haonan Wu, Xiaobing Pang

и другие.

Environment International, Год журнала: 2023, Номер 180, С. 108240 - 108240

Опубликована: Сен. 28, 2023

Atmospheric particulate matter (PM) poses great adverse effects through the production of reactive oxygen species (ROS). Various components in PM are acknowledged to induce ROS formation, while interactions among chemicals remain be elucidated. Here, we systematically investigate influence Brown carbon (BrC) surrogates (e.g., imidazoles, nitrocatechols and humic acid) on hydroxyl radical (OH) generation from transition metals (TMs) simulated lung fluid. Present results show that BrC has an antagonism (interaction factor: 20-90 %) with Cu2+ OH upon interaction glutathione, which concentrations TMs extent antagonism. Rapid glutathione is observed for Fe2+, formation very little Fe3+. The compositions antioxidants ascorbate, urate), resembling upper lower respiratory tract, respond differently (Cu2+, Fe2+ Fe3+) degree complexation equilibrium constants site numbers between acid were further analyzed using fluorescence quenching experiments. Possible products TMs, 4-nitrocatechol also identified quadropule-time-of-flight mass spectrometry. suggest atmospheric widely participate human fluid, should considered evaluating mediated by ambient PM.

Язык: Английский

Ascorbate oxidation driven by PM2.5-bound metal(loid)s extracted in an acidic simulated lung fluid in relation to their bioaccessibility DOI Creative Commons
Andrea Expósito, Bohdana Markiv, Miguel Santibáñez

и другие.

Air Quality Atmosphere & Health, Год журнала: 2023, Номер 17(1), С. 177 - 189

Опубликована: Сен. 28, 2023

Abstract The oxidative potential (OP) is defined as the ability of inhaled PM components to catalytically/non-catalytically generate reactive oxygen species (ROS) and deplete lung antioxidants. Although several studies have measured OP particulate matter (PM OP) soluble using different antioxidants under neutral pH conditions, few with acidic fluids. This study provides new insights into use rather than fluids in assays. Thus, first aim this was clarify effect an fluid on ascorbic acid (AA) depletion. achieved by measuring (OP-AA) individual compounds known catalyze AA oxidation (CuSO 4 , CuCl 2 1,4-NQ) artificial lysosomal (ALF, 4.5), a commonly used simulated fluid, (phosphate-buffered saline (PBS1x), 7.4). Our results from these showed significant decrease OP-AA (ALF) respect (PBS). Then, second work investigate whether assay could be applied 2.5 samples extracted conditions. For purpose, bioaccessible concentrations metal(loid)s (V, Mn, Fe, Ni, Cu, Zn, As, Mo, Cd, Sb, Pb) collected urban-industrial area that were ALF analyzed. mean volume-normalized (OP-AAv) value 0.10 ± 0.07 nmol min −1 m −3 clearly lower values found literature at pH. OP-AAv highly correlated ALF-bioaccessible concentration most studied metal(loid)s, mainly Cu Fe.

Язык: Английский

Процитировано

7

Seasonal Changes in the Oxidative Potential of Urban Air Pollutants: The Influence of Emission Sources and Proton- and Ligand-Mediated Dissolution of Transition Metals DOI Creative Commons
Pourya Shahpoury, Steven Lelieveld, Deepchandra Srivastava

и другие.

ACS ES&T Air, Год журнала: 2024, Номер 1(10), С. 1262 - 1275

Опубликована: Авг. 29, 2024

The inhalation of fine particulate matter (PM

Язык: Английский

Процитировано

2

Sources of Acellular Oxidative Potential of Water-soluble Fine Ambient Particulate Matter in the Midwestern United States DOI Creative Commons
Haoran Yu, Yixiang Wang, Joseph V. Puthussery

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 474, С. 134763 - 134763

Опубликована: Май 29, 2024

Ambient fine particulate matter (PM2.5) is associated with numerous health complications, yet the specific PM2.5 chemical components and their emission sources contributing to these outcomes are understudied. Our study analyzes composition of collected from five distinct locations at urban, roadside rural environments in midwestern region United States, associates them acellular oxidative potential (OP) endpoints water-soluble PM2.5. Redox-active metals (i.e., Cu, Fe, Mn) carbonaceous species were correlated most OP endpoints, suggesting significant role OP. We conducted a source apportionment analysis using positive matrix factorization (PMF) found strong disparity contribution various mass vs. Regional secondary combustion-related aerosols contributed significantly (> 75% total) mass, but showed weaker (43-69%) Local such as parking emissions, industrial agricultural activities, though accounting marginally (< 10% for each), (10-50%). results demonstrate that effects not necessarily same, emphasizing need an improved air quality management strategy utilizing more health-relevant indicators. Oxidative has been purported relevant metric ambient PM2.5, although standards based only on concentrations. investigates across different sites midwest US. impact These findings highlight develop control strategies which manage regional pollution, also account local minimize overall pollution.

Язык: Английский

Процитировано

2

Review of health effects driven by aerosol acidity: Occurrence and implications for air pollution control DOI

Xiwen Song,

Di Wu,

Yi Su

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 955, С. 176839 - 176839

Опубликована: Окт. 16, 2024

Язык: Английский

Процитировано

2

The complexation of atmospheric Brown carbon surrogates on the generation of hydroxyl radical from transition metals in simulated lung fluid DOI Creative Commons
Yan Lyu, Haonan Wu, Xiaobing Pang

и другие.

Environment International, Год журнала: 2023, Номер 180, С. 108240 - 108240

Опубликована: Сен. 28, 2023

Atmospheric particulate matter (PM) poses great adverse effects through the production of reactive oxygen species (ROS). Various components in PM are acknowledged to induce ROS formation, while interactions among chemicals remain be elucidated. Here, we systematically investigate influence Brown carbon (BrC) surrogates (e.g., imidazoles, nitrocatechols and humic acid) on hydroxyl radical (OH) generation from transition metals (TMs) simulated lung fluid. Present results show that BrC has an antagonism (interaction factor: 20-90 %) with Cu2+ OH upon interaction glutathione, which concentrations TMs extent antagonism. Rapid glutathione is observed for Fe2+, formation very little Fe3+. The compositions antioxidants ascorbate, urate), resembling upper lower respiratory tract, respond differently (Cu2+, Fe2+ Fe3+) degree complexation equilibrium constants site numbers between acid were further analyzed using fluorescence quenching experiments. Possible products TMs, 4-nitrocatechol also identified quadropule-time-of-flight mass spectrometry. suggest atmospheric widely participate human fluid, should considered evaluating mediated by ambient PM.

Язык: Английский

Процитировано

5