Environment International,
Год журнала:
2023,
Номер
180, С. 108240 - 108240
Опубликована: Сен. 28, 2023
Atmospheric
particulate
matter
(PM)
poses
great
adverse
effects
through
the
production
of
reactive
oxygen
species
(ROS).
Various
components
in
PM
are
acknowledged
to
induce
ROS
formation,
while
interactions
among
chemicals
remain
be
elucidated.
Here,
we
systematically
investigate
influence
Brown
carbon
(BrC)
surrogates
(e.g.,
imidazoles,
nitrocatechols
and
humic
acid)
on
hydroxyl
radical
(OH)
generation
from
transition
metals
(TMs)
simulated
lung
fluid.
Present
results
show
that
BrC
has
an
antagonism
(interaction
factor:
20-90
%)
with
Cu2+
OH
upon
interaction
glutathione,
which
concentrations
TMs
extent
antagonism.
Rapid
glutathione
is
observed
for
Fe2+,
formation
very
little
Fe3+.
The
compositions
antioxidants
ascorbate,
urate),
resembling
upper
lower
respiratory
tract,
respond
differently
(Cu2+,
Fe2+
Fe3+)
degree
complexation
equilibrium
constants
site
numbers
between
acid
were
further
analyzed
using
fluorescence
quenching
experiments.
Possible
products
TMs,
4-nitrocatechol
also
identified
quadropule-time-of-flight
mass
spectrometry.
suggest
atmospheric
widely
participate
human
fluid,
should
considered
evaluating
mediated
by
ambient
PM.
Air Quality Atmosphere & Health,
Год журнала:
2023,
Номер
17(1), С. 177 - 189
Опубликована: Сен. 28, 2023
Abstract
The
oxidative
potential
(OP)
is
defined
as
the
ability
of
inhaled
PM
components
to
catalytically/non-catalytically
generate
reactive
oxygen
species
(ROS)
and
deplete
lung
antioxidants.
Although
several
studies
have
measured
OP
particulate
matter
(PM
OP)
soluble
using
different
antioxidants
under
neutral
pH
conditions,
few
with
acidic
fluids.
This
study
provides
new
insights
into
use
rather
than
fluids
in
assays.
Thus,
first
aim
this
was
clarify
effect
an
fluid
on
ascorbic
acid
(AA)
depletion.
achieved
by
measuring
(OP-AA)
individual
compounds
known
catalyze
AA
oxidation
(CuSO
4
,
CuCl
2
1,4-NQ)
artificial
lysosomal
(ALF,
4.5),
a
commonly
used
simulated
fluid,
(phosphate-buffered
saline
(PBS1x),
7.4).
Our
results
from
these
showed
significant
decrease
OP-AA
(ALF)
respect
(PBS).
Then,
second
work
investigate
whether
assay
could
be
applied
2.5
samples
extracted
conditions.
For
purpose,
bioaccessible
concentrations
metal(loid)s
(V,
Mn,
Fe,
Ni,
Cu,
Zn,
As,
Mo,
Cd,
Sb,
Pb)
collected
urban-industrial
area
that
were
ALF
analyzed.
mean
volume-normalized
(OP-AAv)
value
0.10
±
0.07
nmol
min
−1
m
−3
clearly
lower
values
found
literature
at
pH.
OP-AAv
highly
correlated
ALF-bioaccessible
concentration
most
studied
metal(loid)s,
mainly
Cu
Fe.
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
474, С. 134763 - 134763
Опубликована: Май 29, 2024
Ambient
fine
particulate
matter
(PM2.5)
is
associated
with
numerous
health
complications,
yet
the
specific
PM2.5
chemical
components
and
their
emission
sources
contributing
to
these
outcomes
are
understudied.
Our
study
analyzes
composition
of
collected
from
five
distinct
locations
at
urban,
roadside
rural
environments
in
midwestern
region
United
States,
associates
them
acellular
oxidative
potential
(OP)
endpoints
water-soluble
PM2.5.
Redox-active
metals
(i.e.,
Cu,
Fe,
Mn)
carbonaceous
species
were
correlated
most
OP
endpoints,
suggesting
significant
role
OP.
We
conducted
a
source
apportionment
analysis
using
positive
matrix
factorization
(PMF)
found
strong
disparity
contribution
various
mass
vs.
Regional
secondary
combustion-related
aerosols
contributed
significantly
(>
75%
total)
mass,
but
showed
weaker
(43-69%)
Local
such
as
parking
emissions,
industrial
agricultural
activities,
though
accounting
marginally
(<
10%
for
each),
(10-50%).
results
demonstrate
that
effects
not
necessarily
same,
emphasizing
need
an
improved
air
quality
management
strategy
utilizing
more
health-relevant
indicators.
Oxidative
has
been
purported
relevant
metric
ambient
PM2.5,
although
standards
based
only
on
concentrations.
investigates
across
different
sites
midwest
US.
impact
These
findings
highlight
develop
control
strategies
which
manage
regional
pollution,
also
account
local
minimize
overall
pollution.
Environment International,
Год журнала:
2023,
Номер
180, С. 108240 - 108240
Опубликована: Сен. 28, 2023
Atmospheric
particulate
matter
(PM)
poses
great
adverse
effects
through
the
production
of
reactive
oxygen
species
(ROS).
Various
components
in
PM
are
acknowledged
to
induce
ROS
formation,
while
interactions
among
chemicals
remain
be
elucidated.
Here,
we
systematically
investigate
influence
Brown
carbon
(BrC)
surrogates
(e.g.,
imidazoles,
nitrocatechols
and
humic
acid)
on
hydroxyl
radical
(OH)
generation
from
transition
metals
(TMs)
simulated
lung
fluid.
Present
results
show
that
BrC
has
an
antagonism
(interaction
factor:
20-90
%)
with
Cu2+
OH
upon
interaction
glutathione,
which
concentrations
TMs
extent
antagonism.
Rapid
glutathione
is
observed
for
Fe2+,
formation
very
little
Fe3+.
The
compositions
antioxidants
ascorbate,
urate),
resembling
upper
lower
respiratory
tract,
respond
differently
(Cu2+,
Fe2+
Fe3+)
degree
complexation
equilibrium
constants
site
numbers
between
acid
were
further
analyzed
using
fluorescence
quenching
experiments.
Possible
products
TMs,
4-nitrocatechol
also
identified
quadropule-time-of-flight
mass
spectrometry.
suggest
atmospheric
widely
participate
human
fluid,
should
considered
evaluating
mediated
by
ambient
PM.
