ACS ES&T Engineering,
Год журнала:
2023,
Номер
4(1), С. 66 - 95
Опубликована: Окт. 12, 2023
The
constant
development
of
computer
systems
and
infrastructure
has
allowed
computational
chemistry
to
become
an
important
component
environmental
research.
In
the
past
decade,
application
quantum
classical
mechanical
calculations
model
understand
increased
exponentially.
this
review,
we
highlight
various
applications
techniques
in
areas
research
(e.g.,
wastewater/air
treatment,
sensing,
biodegradation).
We
briefly
describe
each
approach,
starting
with
principle
methods
followed
by
molecular
mechanics
(MM),
dynamics
(MD),
hybrid
QM/MM
methods.
recent
introduction
artificial
intelligence
machine
learning
their
potential
disrupt
field
are
also
discussed.
Challenges
current
future
directions
address
them
presented.
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Апрель 17, 2023
Abstract
Nano
plastics
(NPs)
have
been
a
significant
threat
to
human
health
and
are
known
cause
premature
endothelial
senescence.
Endothelial
senescence
is
considered
one
of
the
primary
risk
factors
contributing
numerous
cardiovascular
disorders.
Recent
studies
suggested
that
inhibition
sodium
glucose
co-transporter
(SGLT2)
ameliorates
dysfunction.
Therefore,
our
study
intends
explore
role
SGLT2
in
NPs-induced
Porcine
coronary
artery
its
cells
were
treated
with
NPs
presence
or
absence
Enavogliflozin
(ENA),
inhibitor
then
SGLTs
expression,
markers
vascular
function
evaluated.
significantly
up-regulated
ENA
decreased
senescence-associated-
β
‐gal
activity,
cell‐cycle
arrest,
p53
p21
suggesting
prevents
In
addition,
formation
reactive
oxygen
species
downregulation
Nox2,
p22
phox
.
Furthermore,
also
up
regulated
nitric
oxide
synthase
expression
along
improving
function.
conclusion,
by
is,
at
least
part,
associated
it
could
be
potential
therapeutic
target
for
preventing
and/or
treating
environmental
pollutants-induced
disorders
mediated
ACS Sustainable Chemistry & Engineering,
Год журнала:
2024,
Номер
12(4), С. 1595 - 1604
Опубликована: Янв. 18, 2024
Nanoplastics,
novel
environmental
pollutants
widely
dispersed,
present
challenges
due
to
limited,
dependable
detection
methods,
particularly
for
trace
levels.
This
study
introduces
a
approach
that
integrates
liquid-phase
self-assembly
nanoparticle
technology
with
surface-enhanced
Raman
spectroscopy
(SERS)
the
precise
of
nanoplastics.
Utilizing
hydrophobic–lipophilic
interactions
and
SERS
technology,
we
developed
silver
nanoparticles
(Ag
NPs)@poly(methyl
methacrylate)
(PMMA)
films
NPs@PMMA
films)
efficient
extraction
simultaneous
polystyrene
(PS)
polyethylene
terephthalate
(PET)
nanoplastics
at
extremely
low
concentrations
(e.g.,
10–11
mg/mL
20
nm
PS
10–8
70
PET
nanoplastics).
It
also
demonstrates
linear
correlation
between
intensity
(y)
logarithm
nanoplastics'
concentration
(lg
c)
technique's
applicability
extends
real
samples,
such
as
seawater,
oysters,
bottled
water,
enabling
both
qualitative
quantitative
For
example,
it
successfully
identifies
1.23
×
10–10
in
seawater
samples
8.61
10–5
bottled-water
samples.
Overall,
these
findings
provide
reliable
basis
nanoplastic
environment,
addressing
pressing
concern.
Abstract
Intracellular
delivery
of
nano‐drug‐carriers
(NDC)
to
specific
cells,
diseased
regions,
or
solid
tumors
has
entered
the
era
precision
medicine
that
requires
systematic
knowledge
nano‐biological
interactions
from
multidisciplinary
perspectives.
To
this
end,
review
first
provides
an
overview
membrane‐disruption
methods
such
as
electroporation,
sonoporation,
photoporation,
microfluidic
delivery,
and
microinjection
with
merits
high‐throughput
enhanced
efficiency
for
in
vitro
NDC
delivery.
The
impact
characteristics
including
particle
size,
shape,
charge,
hydrophobicity,
elasticity
on
cellular
uptake
are
elaborated
several
types
systems
aiming
hierarchical
targeting
vivo
reviewed.
Emerging
ex
human/animal‐derived
pathophysiological
models
further
explored
highly
recommended
use
studies
since
they
might
mimic
features
fill
translational
gaps
animals
humans.
exploration
modern
microscopy
techniques
precise
nanoparticle
(NP)
tracking
at
cellular,
organ,
organismal
levels
informs
tailored
development
NDCs
application
clinical
translation.
Overall,
integrates
latest
insights
into
smart
nanosystem
engineering,
physiological
models,
imaging‐based
validation
tools,
all
directed
towards
enhancing
efficient
intracellular
NDCs.
Journal of Physics Photonics,
Год журнала:
2024,
Номер
6(2), С. 025002 - 025002
Опубликована: Фев. 2, 2024
Abstract
Surface-enhanced
Raman
spectroscopy
(SERS)
is
a
powerful
optical
sensing
technique
used
in
various
applications,
including
medicine,
microbiology,
and
environmental
analysis.
Planar
SERS
substrates
are
of
particular
interest
due
to
their
ease
integration
lab-on-chips
better
reproducibility
compared
colloidal
SERS.
The
performance
these
quantified
using
metrics
such
as
enhancement
factor,
sensitivity,
reproducibility.
However,
there
yet
be
consensus
on
how
practically
compare
interpret
publications
experiments.
These
strongly
influenced
by
the
nanostructures’
material,
architecture,
element
sizes,
well
circumstances
surrounding
Understanding
effect
characteristics
substrates’
could
not
only
enable
but
also
direct
development
for
different
applications.
Thus,
we
prepared
planar
SERS-substrate
characterization
methodology
explore
correlation
between
physical
through
coordinate-transformed
spectroscopic
measurements
over
structure-characterized
areas.
Seven
commercial
substrates,
with
surface
architectures
fabricated
fabrication
technologies,
were
studied
this
benchmarking
methodology.
results
demonstrated
can
indicate
substrate’s
suitability
specific
application,
thus,
guiding
further
adaptations
or
development.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(26), С. 10772 - 10779
Опубликована: Июнь 21, 2024
A
simple,
sustainable,
and
sensitive
monitoring
approach
of
micro/nanoplastics
(MNPs)
in
aqueous
samples
is
crucial
since
it
helps
assessing
the
extent
contamination
understanding
potential
risks
associated
with
their
presence
without
causing
additional
stress
to
environment.
In
this
study,
a
novel
strategy
for
qualitative
quantitative
determination
MNPs
water
by
direct
solid-phase
microextraction
(SPME)
coupled
gas
chromatography–mass
spectrometry
(GC-MS)
was
proposed
first
time.
Spherical
poly(methyl
methacrylate)
(PMMA)
irregularly
shaped
polyvinyl
dichloride
(PVDC)
were
used
evaluate
feasibility
performance
method.
The
results
demonstrated
that
both
PMMA
PVDC
efficiently
extracted
homemade
SPME
coating
nitrogen-doped
porous
carbons
(N-SPCs)
exhibited
sufficient
thermal
decomposition
GC-MS
injection
port.
Excellent
extraction
performances
N-SPCs
are
attributed
hydrophobic
cross-linking,
electrostatic
forcing,
hydrogen
bonding,
pore
trapping.
Methyl
methacrylate
identified
as
marker
PMMA,
while
1,3-dichlorobenzene
1,3,5-trichlorobenzene
indicators
PVDC.
Under
optimal
conditions,
method
ultrahigh
sensitivity,
limit
detection
0.0041
μg/L
0.0054
Notably,
programmed
temperature
injector
developed
discriminate
eliminate
interferences
intrinsic
indicator
compounds.
Owing
integration
sampling,
extraction,
injection,
into
one
step
SPME,
demonstrates
exceptional
eliminating
necessity
complex
sample
pretreatment
procedures
use
organic
solvents.
Finally,
successfully
applied
real
samples.
The Science of The Total Environment,
Год журнала:
2025,
Номер
968, С. 178923 - 178923
Опубликована: Фев. 21, 2025
Plastic
particles
in
the
range
of
1
nm
to
μm
diameter
are
nano
pollutants
all
environments,
ubiquitous
throughout
air,
waters
and
living
organisms.
The
formation
nanoplastics
(NP)
occurs
different
ways
that
include
material
abrasion,
light
exposure
even
from
normal
use
plastic
materials.
In
solvents,
NP
small
microplastics
(<
10
diameter)
differ
larger
they
can
mix
suspend,
similar
other
colloidal
sized
particles.
this
study,
we
used
mixing
conditions
our
novel
solubilization
method
generate
polyethylene
(PE)
microplastic
nanoplastic
solutions
(sM&NP),
both
water
common
organic
solvents.
sM&NP
were
examined
using
Raman
spectroscopy
microscopy,
transmission
electron
microscopy
(TEM)
particle
size
analysis
dynamic
scattering
(DLS)
methods.
data
showed
notable
spectral
changes
compared
solid
PE,
which
indicates
significant
molecular
morphological
PE
polymer
when
it
is
part
these
or
suspensions.
for
signified
a
loss
crystallinity,
while
aqueous
suggest
greater
reorganization
structure.
These
structural
supported
by
TEM
images
appeared
mostly
amorphous
with
varying
thickness.
Importantly,
changed
spectra
likely
render
them
more
difficult
detect
particularly
real-world
systems.
findings
indicate
solubilized
routinely
modified
solvent
exposure,
thereby
interact
differently
materials,
environments.
