Environmental Pollution, Год журнала: 2023, Номер 329, С. 121721 - 121721
Опубликована: Апрель 26, 2023
Язык: Английский
Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136155 - 136155
Опубликована: Окт. 15, 2024
Язык: Английский
Процитировано
8
Water Research, Год журнала: 2024, Номер 257, С. 121669 - 121669
Опубликована: Апрель 23, 2024
Язык: Английский
Процитировано
7
Frontiers in Environmental Science, Год журнала: 2024, Номер 12
Опубликована: Май 28, 2024
Introduction Tire and road wear particles are one of the most abundant types microplastic entering environment. The toxicity tire has been linked to their organic additives associated transformation products. particles, tire-derived compounds introduced agricultural environment via atmospheric deposition, irrigation with reclaimed wastewater, use biosolids (treated sewage sludge) as fertilizer. In environment, these could be taken up by edible plants, leading human exposure. Methods Sixteen were measured in twenty-eight commercial leafy vegetable samples from four countries. Based on results, estimated daily intake was calculated due consumption based local diets under a mean maximum concentration scenario. Results vegetables, six detected: benzothiazole (maximum concentration—238 ng/g dry weight), 2-hydroxybenzothiazole concentration—665 1,3-diphenylguanidine concentration—2.1 N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD, concentration—0.4 N-Isopropyl-N-phenyl-4-phenylenediamine (IPPD, concentration—0.1 N-phenyl-N-cyclohexyl-p-phenylenediamine (CPPD, concentration—0.3 weight). At least compound present 71% analyzed. for ranged 0.05 ng/person/day scenario 4.0 scenario; 12 1,296 ng/person/day; 6PPD 0.06 2.6 IPPD 0.04 1.1 CPPD ng/person/day. Discussion Statistical analyses did not reveal correlation between known growth conditions concentrations samples. generally lower than or comparable other sources. However, we show that foodstuff, exposure might higher produce. Future studies needed uncover pathways food, assess products, investigate biological effects this
Язык: Английский
Процитировано
7
Environmental Science and Ecotechnology, Год журнала: 2025, Номер 25, С. 100567 - 100567
Опубликована: Май 1, 2025
N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its oxidation derivative, 6PPD-quinone (6PPDQ), have been extensively detected in environmental biological samples, raising significant concerns regarding their chronic aquatic toxicity at environmentally relevant concentrations. However, the underlying mechanisms driving this remain largely unexplored. Here we show that zebrafish exposed to 6PPD 6PPDQ exhibit distinct toxicokinetic profiles, with preferentially accumulating liver predominantly targeting brain. Exposure both compounds impaired growth, induced hepatic damage, disrupted locomotor behavior. Transcriptomic analysis of tissue revealed disturbances lipid carbohydrate metabolic pathways treatment groups, differences gene expression patterns biochemical responses between 6PPDQ. Specifically, downregulated peroxisome proliferator-activated receptor gamma (PPARγ) elevated pro-inflammatory cytokines (TNF-α IL-6). Molecular dynamics simulations surface plasmon resonance experiments further demonstrated hepatotoxicity was associated direct binding these PPARγ, a critical regulator metabolism inflammation. Our findings highlight hepatotoxic risks life. Importantly, exhibited greater compared 6PPD, emphasizing an urgent need for targeted controls regulatory actions mitigate ecological harm potential public health consequences.
Язык: Английский
Процитировано
1
Environmental Pollution, Год журнала: 2023, Номер 329, С. 121721 - 121721
Опубликована: Апрель 26, 2023
Язык: Английский
Процитировано
17