6PPD, Not 6PPD-Quinone, Induced Serious Zebrafish Eye Damage by Disrupting the Thyroid Signaling Pathway DOI
Jing Chang,

Leisen Zhang,

Juan Zhao

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 4, 2024

N-(1,3-Dimethylbutyl)-N′-phenyl-1,4-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPDQ) showed different acute toxicities bioaccumulation potencies in fish. In this study, we compared the thyroid disrupting effects of 6PPD 6PPDQ through vitro, silico, vivo assays. Interestingly, although similar docking affinities with hormone receptor (TR) isoforms GH3 cell inhibition effects, signaling pathway, eye development, phototactic behaviors, density retinal layer larval zebrafish were significantly affected only following exposure. Further investigation demonstrates that can act as a TR antagonist to reduce opsin protein abundance inhibit cone photoreceptor proliferation, which finally alters structure causes microphthalmus zebrafish. Especially, under environmental relevant concentration exposure, induced alterations trβ, opn1lw1, opn1mw1, rpe65a, nr2e3 gene expressions no significant histopathological change was observed. This study illustrates for first time more serious visual system impairment 6PPDQ, disruption being contributing factor, while other important toxic targets still require further research.

Язык: Английский

Transfer Learning with a Graph Attention Network and Weighted Loss Function for Screening of Persistent, Bioaccumulative, Mobile, and Toxic Chemicals DOI
Haobo Wang, Wenjia Liu, Jingwen Chen

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

methods for screening hazardous chemicals are necessary sound management. Persistent, bioaccumulative, mobile, and toxic (PBMT) persist in the environment have high mobility aquatic environments, posing risks to human ecological health. However, lack of experimental data vast number hinders identification PBMT chemicals. Through an extensive search measured chemical data, as well persistent, (PBT) inventories, this study constructed comprehensive sets on To address limited volume set, a transfer learning (TL) framework based graph attention network (GAT) architecture was developed construct models chemicals, designating PBT inventories source domains set target domains. A weighted loss (

Язык: Английский

Процитировано

1
Negative effects on the adaptive strategies of the lizards (Eremias argus) under starvation after exposure to Glufosinate-ammonium DOI
L Zhang,

Danyang Zhang,

Bufan Xu

и другие.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2024, Номер 287, С. 110036 - 110036

Опубликована: Сен. 7, 2024

Язык: Английский

Процитировано

0
6PPD, Not 6PPD-Quinone, Induced Serious Zebrafish Eye Damage by Disrupting the Thyroid Signaling Pathway DOI
Jing Chang,

Leisen Zhang,

Juan Zhao

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 4, 2024

N-(1,3-Dimethylbutyl)-N′-phenyl-1,4-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPDQ) showed different acute toxicities bioaccumulation potencies in fish. In this study, we compared the thyroid disrupting effects of 6PPD 6PPDQ through vitro, silico, vivo assays. Interestingly, although similar docking affinities with hormone receptor (TR) isoforms GH3 cell inhibition effects, signaling pathway, eye development, phototactic behaviors, density retinal layer larval zebrafish were significantly affected only following exposure. Further investigation demonstrates that can act as a TR antagonist to reduce opsin protein abundance inhibit cone photoreceptor proliferation, which finally alters structure causes microphthalmus zebrafish. Especially, under environmental relevant concentration exposure, induced alterations trβ, opn1lw1, opn1mw1, rpe65a, nr2e3 gene expressions no significant histopathological change was observed. This study illustrates for first time more serious visual system impairment 6PPDQ, disruption being contributing factor, while other important toxic targets still require further research.

Язык: Английский

Процитировано

0