Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 8, 2025
The
escalating
environmental
concern
over
secondary
microplastics
(SMPs)
stems
from
their
physicochemical
evolution
primary
(PMPs),
yet
the
contribution
of
varying
transformations
to
ultimate
risks
remains
unknown.
In
this
study,
a
photomechanical
degradation
process
was
employed
convert
sunscreen-derived
(SDMPs)
into
SDMPs.
While
mechanical
caused
physical
fragmentation,
photodegradation
induced
both
and
chemical
alterations,
introducing
surface
oxidation,
bond
scission,
cross-linking
Employing
combination
alkaline
digestion
pyrolysis
GC-MS
techniques,
it
observed
that
fragmentation
photooxidation
led
heightened
intracellular
sequestration
MPs.
Although
bioaccumulated
SDMPs
could
be
indicated
by
enlarged
lysosomes
fragmented
mitochondria,
toxicity
at
cellular
level
primarily
driven
post-photodegradation.
A
nontargeted
analysis
employing
high-resolution
mass
spectrometry
identified
46
plastic-associated
compounds
in
leachate,
with
photodegradation-induced
playing
crucial
role
dissociation
hydrophobic
additives
oxidative
conversion
leached
compounds.
leachate
exacerbated
photodegradation,
mitochondrial
serving
as
subcellular
biomarker,
indicative
toxicity.
This
study
elucidates
pivotal
augmenting
cytotoxicity
SDMPs,
shedding
light
on
intricate
interplay
between
risks.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
283, С. 116777 - 116777
Опубликована: Июль 24, 2024
Lactation
women,
a
highly
concerned
demographic
in
society,
face
health
risks
that
deserve
attention.
Zinc
oxide
nanoparticles
(ZnO
NPs)
are
widely
utilized
food
and
daily
products
due
to
their
excellent
physicochemical
properties,
leading
the
potential
exposure
of
lactating
women
ZnO
NPs.
Hence,
assessing
associated
with
NP
during
lactation
is
critical.
While
studies
have
confirmed
NPs
can
induce
toxic
responses
multiple
organs
through
blood
circulation,
effects
lactational
on
mammary
tissue
remain
unclear.
This
research
investigated
impairment
induced
by
its
mechanisms.
Through
administering
injections
into
tail
vein
ICR
mice,
our
study
revealed
deposit
tissues,
downregulating
key
components
epithelial
barrier
such
as
ZO-1,
occludin,
claudin-3.
In
vivo,
we
also
found
simultaneously
apoptosis,
necroptosis,
pyroptosis,
called
PANoptosis.
Additionally,
using
EpH4-Ev
cells
simulate
an
vitro
model,
observed
effectively
disrupted
integrity
Furthermore,
PANoptosis
was
responsible
for
disruption
Moreover,
identified
ZBP1
primary
mechanism
inducing
These
discoveries
designed
enhance
comprehension
mechanisms
underlying
caused
NPs,
aim
highlight
hazards
usage
therapeutic
lactation.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 8, 2025
The
escalating
environmental
concern
over
secondary
microplastics
(SMPs)
stems
from
their
physicochemical
evolution
primary
(PMPs),
yet
the
contribution
of
varying
transformations
to
ultimate
risks
remains
unknown.
In
this
study,
a
photomechanical
degradation
process
was
employed
convert
sunscreen-derived
(SDMPs)
into
SDMPs.
While
mechanical
caused
physical
fragmentation,
photodegradation
induced
both
and
chemical
alterations,
introducing
surface
oxidation,
bond
scission,
cross-linking
Employing
combination
alkaline
digestion
pyrolysis
GC-MS
techniques,
it
observed
that
fragmentation
photooxidation
led
heightened
intracellular
sequestration
MPs.
Although
bioaccumulated
SDMPs
could
be
indicated
by
enlarged
lysosomes
fragmented
mitochondria,
toxicity
at
cellular
level
primarily
driven
post-photodegradation.
A
nontargeted
analysis
employing
high-resolution
mass
spectrometry
identified
46
plastic-associated
compounds
in
leachate,
with
photodegradation-induced
playing
crucial
role
dissociation
hydrophobic
additives
oxidative
conversion
leached
compounds.
leachate
exacerbated
photodegradation,
mitochondrial
serving
as
subcellular
biomarker,
indicative
toxicity.
This
study
elucidates
pivotal
augmenting
cytotoxicity
SDMPs,
shedding
light
on
intricate
interplay
between
risks.
